Results 81 to 90 of about 25,053 (234)
L-carnitine protects against carboplatin-mediated renal injury: AMPK- and PPARα-dependent inactivation of NFAT3. [PDF]
PLoS ONE, 2014 We have previously shown that carboplatin induces inflammation and apoptosis in renal tubular cells (RTCs) through the activation of the nuclear factor of activated T cells-3 (NFAT3) protein by reactive oxygen species (ROS), and that the ROS-mediated ...
Yuh-Mou Sue +5 more
doaj +1 more source
ACETYL-L-CARNITINE IN IDIOPATHIC ASTHENOZOOPERMIA
Urology Research and Practice, 2019 In this study we aimed to evaluate any possible effect of acetyl-L-carnitine on sperm motility in patients with idiopathic asthenozoospermia. 42 patients with infertility and idiopathic asthenozoospermia with at least 2 years duration have been ...
B. Alıcı +5 more
doaj +2 more sources
Antioxidants, 2020 Polycystic ovary syndrome (PCOS) is a complex metabolic disorder associated with female infertility. Based on energy and antioxidant regulatory functions of carnitines, we investigated whether acyl-L-carnitines improve PCOS phenotype in a mouse model ...
Giovanna Di Emidio +10 more
doaj +1 more source
Cell Proliferation, EarlyView.In a DHEA+HFD‐induced mouse model, Ins/BBR alleviated mitochondrial defects and broadly reprogrammed metabolic landscape in granulosa cells, in specific, restoring nucleotide pools and amino acid turnover, and preventing abnormal long‐chain fatty acid accumulation.
Juan Ge +8 more
wiley +1 more source
AAD-2004, a potent spin trapping molecule and microsomal prostaglandin E synthase-1 inhibitor, shows safety and efficacy in a mouse model of ALS [PDF]
, 2010 While free radicals and inflammation constitute major routes of neuronal injury occurring in neurodegenerative diseases, neither antioxidants nor nonsteroidal anti-inflammatory drugs (NSAIDs) have shown significant efficacy in human clinical trials.
Bok Yun +12 more
core +1 more source
Adaptive mechanisms of mitochondria in response to exercise [PDF]
, 2013 nem
Kocić Jadranka +2 more
core +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity. It usually results in spectacular weight loss, associated with improvements of obesity‐associated comorbidities. The mechanisms underlying these benefits are not fully understood but could involve a postoperative activation of the enzyme 5′ AMP‐activated ...
Adrien Delcour, Nathalie Niederhoffer
wiley +1 more source
The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]
, 2020 Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
core +1 more source
Toxic and drug-induced peripheral neuropathies: updates on causes, mechanisms and management. [PDF]
, 2013 PURPOSE OF REVIEW: This review discusses publications highlighting current research on toxic, chemotherapy-induced peripheral neuropathies (CIPNs), and drug-induced peripheral neuropathies (DIPNs).
Buclin, T., Diezi, M., Kuntzer, T.
core +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) arises from dysregulated interactions between nutrient delivery, adipose tissue lipid handling and liver lipid metabolism, which collectively coalesce to drive inflammatory signalling leading to metabolic dysfunction‐associated steatohepatitis (MASH) and fibrosis. Recent clinical
Evangelia E. Tsakiridis +1 more
wiley +1 more source