British Journal of Pharmacology, Volume 183, Issue 1, Page 24-39, January 2026.Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley +1 more source
Acetyl-coenzyme A synthetase gene ChAcs1 is essential for lipid metabolism, carbon utilization and virulence of the hemibiotrophic fungus Colletotrichum higginsianum. [PDF]
Mol Plant Pathol, 2019 Gu Q +6 more
europepmc +1 more source
Interaction Between Photoperiod and Sex on Hepatic Lipid Homeostasis in Rats Fed an Obesogenic Diet
The FASEB Journal, Volume 39, Issue 23, 15 December 2025.Male and female Fischer 344 rats were fed a cafeteria (CAF) diet for 11 weeks and exposed to long (L18, 18 h of light per day) or short (L6, 6 h of light per day) photoperiods for 8 weeks. Photoperiod and sex influenced hepatic steatosis, plasmatic and hepatic lipid levels, and hepatic lipid handling, showing sex‐specific metabolic responses to ...
Saioa Gómez‐Roncal +6 more
wiley +1 more source
Introducing Quantitative Assessment of Michaelis Constant (Km) Accuracy
ChemBioChem, Volume 26, Issue 24, December 11, 2025.The Michaelis constant (Km) is often reported with misleading confidence when only standard errors are considered. The accuracy confidence interval (ACI) framework is adapted to Km by recasting velocity–substrate data as a binding isotherm, propagating systematic uncertainties in enzyme and substrate concentrations.
Tong Ye Wang +7 more
wiley +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, Volume 599, Issue 24, Page 3569-3590, December 2025.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Advanced Science, Volume 12, Issue 47, December 18, 2025.This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen +8 more
wiley +1 more source
Fitness costs associated with acetyl-coenzyme A carboxylase mutations endowing herbicide resistance in American sloughgrass (Beckmannia syzigachne Steud.). [PDF]
Ecol Evol, 2019 Du L +6 more
europepmc +1 more source
Activation of acetyl-coenzyme A carboxylase is involved in Taxol-induced ovarian cancer cell death
, 2011 Jiang Wu +4 more
openalex +2 more sources
cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression
Advanced Science, Volume 12, Issue 46, December 11, 2025.cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang +14 more
wiley +1 more source