Results 121 to 130 of about 384,768 (384)

HDAC6 is a bruchpilot deacetylase that facilitates neurotransmitter release [PDF]

, 2014
Presynaptic densities are specialized structures involved in synaptic vesicle tethering and neurotransmission; however, the mechanisms regulating their function remain understudied.
Dermaut, Bart, Feiguin, Fabian, Jose, Liya E, Miskiewicz, Katarzyna, Munck, Sebastian, Swerts, Jef, Valadas, Jorge S, Verstreken, Patrik, Yeshaw, Wondwossen M   +8 more
core   +3 more sources

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Epigenetic Chromatin Silencing: Bistability and Front Propagation

, 2007
The role of post-translational modification of histones in eukaryotic gene regulation is well recognized. Epigenetic silencing of genes via heritable chromatin modifications plays a major role in cell fate specification in higher organisms.
Alberts B, Allis C D, Anirvan M Sengupta, Arkin A, Bi X, Donze D, Fall C P, Gilbert S, Lodish H, Mohammad Sedighi, Ptashne M, Raser J M, Singer M S, Stillman B   +13 more
core   +1 more source

Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart [PDF]

, 2014
The α subunit of the cardiac voltage-gated sodium channel, Naᵥ1.5, provides the rapid sodium inward current that initiates cardiomyocyte action potentials.
Batlle, Montserrat, Beltran-Alvarez, Pedro, Brugada, Ramon, Chiva, Cristina, Chiva, Critina, Pagans, Sara, Perez-Serra, Alexandra, Perez-Villa, Felix, Pérez-Serra, Alexandra, Pérez-Villa, Félix, Sabido, Eduard, Sabidó, Eduard, Schulte, Uwe, Tarradas, Anna   +13 more
core   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden, Charles Carron, Donatienne Van Weehaeghe, Joke De Vocht, Fouke Ombelet, Pegah Masrori, Caro De Weerdt, Rebecca E. James, Lauren T. Evans, Frederick A. Schroeder, Jacob M. Hooker, Michel Koole, Janice E. Kranz, Tonya M. Gilbert, Philip Van Damme, Koen Van Laere   +15 more
wiley   +1 more source

Acetyl Content of Marinobufagin, Arenobufagin and Acetyl-marinobufagin [PDF]

Nature, 1940
FOR marinobufagin, first isolated by Abel and Maeht1 from Bufo marinus and afterwards by Deulofeu and Mendive2 from B. paracnemis, Slotta and Neisser3 suggested the formula C27H38O6, at variance with C24H32O5 accepted by Jensen in many of his papers. They supposed that mar inobuf agin could contain one propionyl group.
E. Duperat, R. Labriola, V. Deulofeu
openaire   +2 more sources

Acetylation Disfavors Tau Phase Separation

International Journal of Molecular Sciences, 2018
Neuropathological aggregates of the intrinsically disordered microtubule-associated protein Tau are hallmarks of Alzheimer’s disease, with decades of research devoted to studying the protein’s aggregation properties both in vitro and in vivo.
J. Ferreon, Antrix Jain, K. Choi, Phoebe S. Tsoi, K. MacKenzie, S. Jung, A. C. Ferreon   +6 more
semanticscholar   +1 more source

PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth. [PDF]

, 2019
p53 acetylation is indispensable for its transcriptional activity and tumor suppressive function. However, the identity of reader protein(s) for p53 acetylation remains elusive. PBRM1, the second most highly mutated tumor suppressor gene in kidney cancer,
Cai, Weijia, Dulaimi, Essel, Jiang, Wei, Langbein, Lauren, Liao, Lili, Liu, Zongzhi Z, Su, Liya, Testa, Joseph R, Uzzo, Robert G, Yan, Qin, Yang, Haifeng, Zhang, Qing, Zhong, Zhijiu   +12 more
core   +1 more source