Results 11 to 20 of about 259,600 (294)
Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
Nature Communications, 2019 Many human proteins are regulated by lysine acetylation, but the degree of acetylation at individual sites is poorly characterized. Here, the authors measure acetylation stoichiometry in the HeLa cell proteome, providing a resource to assess mechanistic ...
Bogi Karbech Hansen +7 more
doaj +2 more sources
Acetylation in the regulation of autophagy
Autophagy, 2022 Post-translational modifications, such as phosphorylation, ubiquitination and acetylation, play crucial roles in the regulation of autophagy. Acetylation has emerged as an important regulatory mechanism for autophagy.
Yinfeng Xu, W. Wan
semanticscholar +1 more source
Cell Death and Differentiation, 2021 High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis.
Kun Yang +10 more
semanticscholar +1 more source
Transcription shapes genome-wide histone acetylation patterns
Nature Communications, 2021 Histone acetylation is a ubiquitous hallmark of transcription, but whether the link between histone acetylation and transcription is causal or consequential has not been addressed.
B. Martin +6 more
semanticscholar +1 more source
Nature Cell Biology, 2020 Immunotherapies that target programmed cell death protein 1 (PD-1) and its ligand PD-L1 as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have shown impressive clinical outcomes for multiple tumours.
Yang Gao +26 more
semanticscholar +1 more source
Molecular Neurodegeneration, 2021 Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic dysregulation and specifically altered histone ...
L. Toker +8 more
semanticscholar +1 more source
mSystems, 2016 N ε-Lysine acetylation has been recognized as a ubiquitous regulatory posttranslational modification that influences a variety of important biological processes in eukaryotic cells.
Valerie J. Carabetta +4 more
doaj +1 more source
N-terminal acetylation can stabilize proteins independent of their ubiquitination
Scientific Reports, 2023 The majority of proteins in mammalian cells are modified by covalent attachment of an acetyl-group to the N-terminus (Nt-acetylation). Paradoxically, Nt-acetylation has been suggested to inhibit as well as to promote substrate degradation.
Bert van de Kooij +6 more
doaj +1 more source
Cells, 2022 Mitochondrial protein acetylation is associated with a host of diseases including cancer, Alzheimer’s, and metabolic syndrome. Deciphering the mechanisms regarding how protein acetylation contributes to disease pathologies remains difficult due to the ...
Courtney D. McGinnis +4 more
doaj +1 more source
Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules
bioRxiv, 2021 Protein acetylation is a central event in orchestrating diverse cellular processes. However, current strategies to investigate protein acetylation in cells are often non-specific or lack temporal and magnitude control.
W. Wang +6 more
semanticscholar +1 more source