Results 11 to 20 of about 191,770 (239)

Acetyl-CoA Carboxylase Regulates Global Histone Acetylation [PDF]

Journal of Biological Chemistry, 2012
Histone acetylation depends on intermediary metabolism for supplying acetyl-CoA in the nucleocytosolic compartment. However, because nucleocytosolic acetyl-CoA is also used for de novo synthesis of fatty acids, histone acetylation and synthesis of fatty acids compete for the same acetyl-CoA pool.
Luciano, Galdieri, Ales, Vancura
openaire   +2 more sources

Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae

Molecular Systems Biology, 2014
Lysine acetylation is a frequently occurring posttranslational modification; however, little is known about the origin and regulation of most sites.
Brian T. Weinert, Vytautas Iesmantavicius, Tarek Moustafa, Christian Schölz, Sebastian A. Wagner, Christoph Magnes, Rudolf Zechner, Chunaram Choudhary   +7 more
doaj   +1 more source

Lysine acetylation decreases enzyme activity and protein level of Escherichia coli lactate dehydrogenase

Engineering Microbiology, 2022
Lactate is an important bulk chemical with widespread applications and a major byproduct of other chemicals bioprocess in microbial fermentation. Lactate dehydrogenase A (LdhA) catalyzes the synthesis of lactate from pyruvate.
Min Liu, Meitong Huo, Likun Guo, Yingxin Fu, Mo Xian, Qingsheng Qi, Wei Liu, Guang Zhao   +7 more
doaj   +1 more source

Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II

Cell Reports, 2017
Summary: Acetyl coenzyme A (AcCoA), a key intermediate in mitochondrial metabolism, N-acetylates lysine residues, disrupting and, in some cases, regulating protein function.
Andrew M. James, Kurt Hoogewijs, Angela Logan, Andrew R. Hall, Shujing Ding, Ian M. Fearnley, Michael P. Murphy   +6 more
doaj   +1 more source

Biochemical Mechanisms of Sirtuin-Directed Protein Acylation in Hepatic Pathologies of Mitochondrial Dysfunction

Cells, 2022
Mitochondrial protein acetylation is associated with a host of diseases including cancer, Alzheimer’s, and metabolic syndrome. Deciphering the mechanisms regarding how protein acetylation contributes to disease pathologies remains difficult due to the ...
Courtney D. McGinnis, Erin Q. Jennings, Peter S. Harris, James J. Galligan, Kristofer S. Fritz   +4 more
doaj   +1 more source

The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation

Cellular & Molecular Biology Letters, 2022
Canonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a central role in the progression of various cancers. The cellular factors that participate in the regulation of this signaling are still not fully elucidated.
Hongjuan You, Qi Li, Delong Kong, Xiangye Liu, Fanyun Kong, Kuiyang Zheng, Renxian Tang   +6 more
doaj   +1 more source

Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members. [PDF]

PLoS ONE, 2016
Lysine acetylation has emerged as a dominant post-translational modification (PTM) regulating tau proteins in Alzheimer's disease (AD) and related tauopathies.
Andrew W Hwang, Hanna Trzeciakiewicz, Dave Friedmann, Chao-Xing Yuan, Ronen Marmorstein, Virginia M Y Lee, Todd J Cohen   +6 more
doaj   +1 more source

Skeletal muscle alpha actin acetylation enhances myosin binding and increases calcium sensitivity

Biophysical Reports
Skeletal muscle alpha actin (ACTA1) is important for muscle contraction and relaxation, with historical studies focused on ACTA1 mutations in muscle dysfunction.
Samantha S. Romanick, Luis Godoy, Adrian Lopez, Allison Matsumura, Kiana Boc, Travis J. Stewart, Josh E. Baker, Bradley S. Ferguson   +7 more
doaj   +1 more source

Acetylation of WRN protein regulates its stability by inhibiting ubiquitination. [PDF]

PLoS ONE, 2010
WRN is a multi-functional protein involving DNA replication, recombination and repair. WRN acetylation has been demonstrated playing an important role in response to DNA damage.
Kai Li, Rui Wang, Enerlyn Lozada, Wei Fan, David K Orren, Jianyuan Luo   +5 more
doaj   +1 more source

How important is the N-terminal acetylation of alpha-synuclein for its function and aggregation into amyloids?

Frontiers in Neuroscience, 2022
N-α-acetylation is a frequently occurring post-translational modification in eukaryotic proteins. It has manifold physiological consequences on the regulation and function of several proteins, with emerging studies suggesting that it is a global ...
Aditya Iyer, Arshdeep Sidhu, Vinod Subramaniam   +2 more
doaj   +1 more source