Results 11 to 20 of about 387,548 (381)
The world of protein acetylation.
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2016 Acetylation is one of the major post-translational protein modifications in the cell, with manifold effects on the protein level as well as on the metabolome level. The acetyl group, donated by the metabolite acetyl-coenzyme A, can be co- or post-translationally attached to either the α-amino group of the N-terminus of proteins or to the ε-amino group ...
Adrian Drazic +3 more
semanticscholar +4 more sources
Quantification of acetylated tubulin [PDF]
Cytoskeleton, 2013 The acetylation/deacetylation of Lys40 of the α-subunit is an important posttranslational modification undergone by tubulin during the life of a cell. Many previous studies have addressed the physiological role of this acetylation process using various ...
Arce, Carlos Angel +3 more
core +5 more sources
Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
Nature Communications, 2019 Many human proteins are regulated by lysine acetylation, but the degree of acetylation at individual sites is poorly characterized. Here, the authors measure acetylation stoichiometry in the HeLa cell proteome, providing a resource to assess mechanistic ...
Bogi Karbech Hansen +7 more
doaj +2 more sources
Cell Death and Differentiation, 2021 High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis.
Kun Yang +10 more
semanticscholar +1 more source
Acetylation in the regulation of autophagy
Autophagy, 2022 Post-translational modifications, such as phosphorylation, ubiquitination and acetylation, play crucial roles in the regulation of autophagy. Acetylation has emerged as an important regulatory mechanism for autophagy.
Yinfeng Xu, W. Wan
semanticscholar +1 more source
Transcription shapes genome-wide histone acetylation patterns
Nature Communications, 2021 Histone acetylation is a ubiquitous hallmark of transcription, but whether the link between histone acetylation and transcription is causal or consequential has not been addressed.
B. Martin +6 more
semanticscholar +1 more source
Agricultural and Biological Chemistry, 1968 In order to elucidate the significance of amino groups as active groups of lysozyme, egg white lysozyme was acetylated with acetic anhydride. The acetylated lysozyme was fractionated by CM-cellulose column chromatography. All acetylated lysozymes fractionated exhibited 120% relative activity toward glycol chitin at pH 5.6, while the optimum pH shifted ...
Nobuyuki Yamasaki +2 more
openalex +5 more sources
The acetylation of insulin [PDF]
Biochemical Journal, 1971 The acetylation of the free amino groups of insulin was studied by reaction of the hormone with N-hydroxysuccinimide acetate at pH6.9 and 8.5. The products formed were separated by chromatography on DEAE-Sephadex and were characterized by isoelectric focusing, by end-group analysis, by the incorporation of [3H]acetyl groups in the molecule, and by ...
Sydney Shall, D. G. Lindsay
openaire +3 more sources
Nature Cell Biology, 2020 Immunotherapies that target programmed cell death protein 1 (PD-1) and its ligand PD-L1 as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have shown impressive clinical outcomes for multiple tumours.
Yang Gao +26 more
semanticscholar +1 more source
Molecular Neurodegeneration, 2021 Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic dysregulation and specifically altered histone ...
L. Toker +8 more
semanticscholar +1 more source