Results 21 to 30 of about 259,600 (294)
Acetylation of GATA4 on Lysine Residue K313 Promotes Osteoblastic Cells Growth
Cellular Physiology and Biochemistry, 2018 Background/Aims: GATA4, a protein related to osteoblast differentiation and mineralization, whose acetylation is essential for cardiac defects. Here, we aimed to explore the functional impacts of GATA4 acetylation on osteoporosis (OS).
Wenjun You, Lijuan Song, Kun Wang
doaj +1 more source
Engineering Microbiology, 2022 Lactate is an important bulk chemical with widespread applications and a major byproduct of other chemicals bioprocess in microbial fermentation. Lactate dehydrogenase A (LdhA) catalyzes the synthesis of lactate from pyruvate.
Min Liu +7 more
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Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae
Molecular Systems Biology, 2014 Lysine acetylation is a frequently occurring posttranslational modification; however, little is known about the origin and regulation of most sites.
Brian T. Weinert +7 more
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Protein Acetylation/Deacetylation: A Potential Strategy for Fungal Infection Control
Frontiers in Microbiology, 2020 Protein acetylation is a universal post-translational modification that fine-tunes the major cellular processes of many life forms. Although the mechanisms regulating protein acetylation have not been fully elucidated, this modification is finely tuned ...
Junzhu Chen +3 more
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Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction
Circulation Research, 2020 Supplemental Digital Content is available in the text. Rationale: Lipid overload-induced heart dysfunction is characterized by cardiomyocyte death, myocardial remodeling, and compromised contractility, but the impact of excessive lipid supply on cardiac ...
Qingxun Hu +12 more
semanticscholar +1 more source
The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation
Cellular & Molecular Biology Letters, 2022 Canonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a central role in the progression of various cancers. The cellular factors that participate in the regulation of this signaling are still not fully elucidated.
Hongjuan You +6 more
doaj +1 more source
Nucleic Acids Research, 2020 MORC family CW-type zinc finger 2 (MORC2) is an oncogenic chromatin-remodeling enzyme with an emerging role in DNA repair. Here, we report a novel function for MORC2 in cell-cycle checkpoint control through an acetylation-dependent mechanism.
Hong-Yi Liu +7 more
semanticscholar +1 more source
Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members. [PDF]
PLoS ONE, 2016 Lysine acetylation has emerged as a dominant post-translational modification (PTM) regulating tau proteins in Alzheimer's disease (AD) and related tauopathies.
Andrew W Hwang +6 more
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Effects of α-tubulin acetylation on microtubule structure and stability
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Microtubules are polymers of αβ-tubulin that play important roles in the cell. Regulation of their dynamics is critical for function and includes the posttranslational modification of tubulin.
L. Eshun-Wilson +9 more
semanticscholar +1 more source
Acetylation of WRN protein regulates its stability by inhibiting ubiquitination. [PDF]
PLoS ONE, 2010 WRN is a multi-functional protein involving DNA replication, recombination and repair. WRN acetylation has been demonstrated playing an important role in response to DNA damage.
Kai Li +5 more
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