Results 21 to 30 of about 374,029 (398)
Transcription shapes genome-wide histone acetylation patterns
Nature Communications, 2021 Histone acetylation is a ubiquitous hallmark of transcription, but whether the link between histone acetylation and transcription is causal or consequential has not been addressed.
B. Martin +6 more
semanticscholar +1 more source
Acetylation-mediated suppression of transcription-independent memory: bidirectional modulation of memory by acetylation. [PDF]
PLoS ONE, 2012 Learning induced changes in protein acetylation, mediated by histone acetyl transferases (HATs), and the antagonistic histone deacetylases (HDACs) play a critical role in memory formation. The status of histone acetylation affects the interaction between
Katja Merschbaecher +2 more
doaj +1 more source
Position-specific analysis and prediction for protein lysine acetylation based on multiple features. [PDF]
PLoS ONE, 2012 Protein lysine acetylation is a type of reversible post-translational modification that plays a vital role in many cellular processes, such as transcriptional regulation, apoptosis and cytokine signaling.
Sheng-Bao Suo +6 more
doaj +1 more source
Discovery of the acetyl cation, CH3CO+, in space and in the laboratory [PDF]
A&A 646, L7 (2021), 2021 Using the Yebes 40m and IRAM 30m radiotelescopes, we detected two series of harmonically related lines in space that can be fitted to a symmetric rotor. The lines have been seen towards the cold dense cores TMC-1, L483, L1527, and L1544. High level of theory ab initio calculations indicate that the best possible candidate is the acetyl cation, CH3CO ...
arxiv +1 more source
The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation
Cellular & Molecular Biology Letters, 2022 Canonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a central role in the progression of various cancers. The cellular factors that participate in the regulation of this signaling are still not fully elucidated.
Hongjuan You +6 more
doaj +1 more source
Nature Cell Biology, 2020 Immunotherapies that target programmed cell death protein 1 (PD-1) and its ligand PD-L1 as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have shown impressive clinical outcomes for multiple tumours.
Yang Gao +26 more
semanticscholar +1 more source
mSystems, 2016 N ε-Lysine acetylation has been recognized as a ubiquitous regulatory posttranslational modification that influences a variety of important biological processes in eukaryotic cells.
Valerie J. Carabetta +4 more
doaj +1 more source
Protein Acetylation/Deacetylation: A Potential Strategy for Fungal Infection Control
Frontiers in Microbiology, 2020 Protein acetylation is a universal post-translational modification that fine-tunes the major cellular processes of many life forms. Although the mechanisms regulating protein acetylation have not been fully elucidated, this modification is finely tuned ...
Junzhu Chen +3 more
doaj +1 more source
Acetylation-dependent coupling between G6PD activity and apoptotic signaling
Nature Communications, 2023 Lysine acetylation has been discovered in thousands of non-histone human proteins, including most metabolic enzymes. Deciphering the functions of acetylation is key to understanding how metabolic cues mediate metabolic enzyme regulation and cellular ...
Fang Wu +7 more
doaj +1 more source
N-terminal acetylation can stabilize proteins independent of their ubiquitination
Scientific Reports, 2023 The majority of proteins in mammalian cells are modified by covalent attachment of an acetyl-group to the N-terminus (Nt-acetylation). Paradoxically, Nt-acetylation has been suggested to inhibit as well as to promote substrate degradation.
Bert van de Kooij +6 more
doaj +1 more source