Results 21 to 30 of about 199,012 (297)
Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members. [PDF]
PLoS ONE, 2016 Lysine acetylation has emerged as a dominant post-translational modification (PTM) regulating tau proteins in Alzheimer's disease (AD) and related tauopathies.
Andrew W Hwang +6 more
doaj +1 more source
The role of protein acetylation in carcinogenesis and targeted drug discovery
Frontiers in Endocrinology, 2022 Protein acetylation is a reversible post-translational modification, and is involved in many biological processes in cells, such as transcriptional regulation, DNA damage repair, and energy metabolism, which is an important molecular event and is ...
Jingru Yang +4 more
doaj +1 more source
Acetylation of WRN protein regulates its stability by inhibiting ubiquitination. [PDF]
PLoS ONE, 2010 WRN is a multi-functional protein involving DNA replication, recombination and repair. WRN acetylation has been demonstrated playing an important role in response to DNA damage.
Kai Li +5 more
doaj +1 more source
Cells, 2021 Tubulin post-translational modifications regulate microtubule properties and functions. Mitotic spindle microtubules are highly modified. While tubulin detyrosination promotes proper mitotic progression by recruiting specific microtubule-associated ...
Sylvia Fenosoa Rasamizafy +5 more
doaj +1 more source
Acetylation, Deacetylation and Acyltransfer [PDF]
Environmental Health Perspectives, 1983 N-Substituted aromatic compounds can be metabolized in most species to N-acetylated derivatives that are themselves subject to further enzymatic transformations, including hydrolysis and N,O-acyltransfer. These proceses can either potentiate or ameliorate the biological responses to these N-substituted derivatives. Decreasing the levels of metabolites,
Irene B. Glowinski, Charles M. King
openaire +3 more sources
The Annealing of Acetylated Potato Starch with Various Substitution Degrees
Molecules, 2021 This study aimed to determine the effect of “annealing” acetylated potato starch with a homogenous granule size and various degrees of substitution on the thermal pasting characteristics (DSC), resistance to amylases, rheology of the prepared pastes ...
Tomasz Zięba +6 more
doaj +1 more source
Lysine acetylation regulates the interaction between proteins and membranes
Nature Communications, 2021 Lysine acetylation regulates the function of soluble proteins in vivo, yet it remains largely unexplored whether lysine acetylation regulates the function of membrane proteins.
Alan K. Okada +14 more
doaj +1 more source
Biomedicines, 2023 Epigenetic mechanisms finely regulate gene expression and represent potential therapeutic targets. Cambinol is a synthetic heterocyclic compound that inhibits class III histone deacetylases known as sirtuins (SIRTs).
Deborah Giordano +8 more
doaj +1 more source
Viruses, 2023 Cyclophilin D (CypD) is regulated during the innate immune response of insects. However, the mechanism by which CypD is activated under innate immunosuppression is not understood.
Dan Yu +5 more
doaj +1 more source
Cell, 2001 Recent studies suggest that acetylation of the p53 tumor suppressor protein is not important for its DNA binding activity, as was previously thought. We discuss here a number of theories as to how this modification may serve to regulate the protein's functions.
James L. Manley, Carol Prives
openaire +3 more sources