Results 31 to 40 of about 374,029 (398)
The role of protein acetylation in carcinogenesis and targeted drug discovery
Frontiers in Endocrinology, 2022 Protein acetylation is a reversible post-translational modification, and is involved in many biological processes in cells, such as transcriptional regulation, DNA damage repair, and energy metabolism, which is an important molecular event and is ...
Jingru Yang +4 more
doaj +1 more source
Acetylation of GATA4 on Lysine Residue K313 Promotes Osteoblastic Cells Growth
Cellular Physiology and Biochemistry, 2018 Background/Aims: GATA4, a protein related to osteoblast differentiation and mineralization, whose acetylation is essential for cardiac defects. Here, we aimed to explore the functional impacts of GATA4 acetylation on osteoporosis (OS).
Wenjun You, Lijuan Song, Kun Wang
doaj +1 more source
Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules
bioRxiv, 2021 Protein acetylation is a central event in orchestrating diverse cellular processes. However, current strategies to investigate protein acetylation in cells are often non-specific or lack temporal and magnitude control.
W. Wang +6 more
semanticscholar +1 more source
Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae
Molecular Systems Biology, 2014 Lysine acetylation is a frequently occurring posttranslational modification; however, little is known about the origin and regulation of most sites.
Brian T. Weinert +7 more
doaj +1 more source
Cells, 2022 Mitochondrial protein acetylation is associated with a host of diseases including cancer, Alzheimer’s, and metabolic syndrome. Deciphering the mechanisms regarding how protein acetylation contributes to disease pathologies remains difficult due to the ...
Courtney D. McGinnis +4 more
doaj +1 more source
Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members. [PDF]
PLoS ONE, 2016 Lysine acetylation has emerged as a dominant post-translational modification (PTM) regulating tau proteins in Alzheimer's disease (AD) and related tauopathies.
Andrew W Hwang +6 more
doaj +1 more source
Nucleic Acids Research, 2020 MORC family CW-type zinc finger 2 (MORC2) is an oncogenic chromatin-remodeling enzyme with an emerging role in DNA repair. Here, we report a novel function for MORC2 in cell-cycle checkpoint control through an acetylation-dependent mechanism.
Hong-Yi Liu +7 more
semanticscholar +1 more source
Acetylation of WRN protein regulates its stability by inhibiting ubiquitination. [PDF]
PLoS ONE, 2010 WRN is a multi-functional protein involving DNA replication, recombination and repair. WRN acetylation has been demonstrated playing an important role in response to DNA damage.
Kai Li +5 more
doaj +1 more source
Lysine residues control the conformational dynamics of beta 2-glycoprotein I [PDF]
, 2020 One of the major problems in the study of the dynamics of proteins is the visualization of changing conformations that are important for processes ranging from enzyme catalysis to signaling. A protein exhibiting conformational dynamics is the soluble blood protein beta 2-glycoprotein I (beta2GPI), which exists in two conformations: the closed (circular)
arxiv +1 more source
Protein acetylation in archaea, bacteria, and eukaryotes [PDF]
, 2010 Proteins can be acetylated at the alpha-amino group of the N-terminal amino acid (methionine or the penultimate amino acid after methionine removal) or at the epsilon-amino group of internal lysines.
Soppa, Jörg (Prof. Dr.)
core +1 more source