Results 31 to 40 of about 387,548 (381)

Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules

bioRxiv, 2021
Protein acetylation is a central event in orchestrating diverse cellular processes. However, current strategies to investigate protein acetylation in cells are often non-specific or lack temporal and magnitude control.
W. Wang, Li-yun Chen, J. Wozniak, Appaso M Jadhav, Hayden R Anderson, Taylor E. Malone, Christopher G. Parker   +6 more
semanticscholar   +1 more source

Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms [PDF]

, 2007
Alteration of chromatin structure by chromatin modifying and remodelling activities is a key stage in the regulation of many nuclear processes. These activities are frequently interlinked, and many chromatin remodelling enzymes contain motifs that ...
Ferreira, Helder, Flaus, Andrew, Owen-Hughes, Tom   +2 more
core   +3 more sources

Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-depleted Murine Embryonic Stem Cells [PDF]

, 2010
Embryonic stem cells (ESC) have the potential to self-renew indefinitely and to differentiate into any of the three germ layers. The molecular mechanisms for self-renewal, maintenance of pluripotency and lineage specification are poorly understood, but ...
A Meissner, A Nishiyama, A Subramanian, B Schölkopf, BD Macarthur, BD Ripley, BE Bernstein, BG Pogo, Breiman, C Schaniel, DE Schones, DE Sterner, DK Pokholok, E Karantzali, E Meshorer, E Meshorer, Edoardo M. Airoldi, EM Airoldi, F Markowetz, FJ Müller, Florian Markowetz, G Hu, GC Yuan, GC Yuan, H Szutorisz, I González, I Ulitsky, Ihor R. Lemischka, Ilya Ioshikhes, J Kim, J Mar, J Schäfer, J Wang, Klaas W. Mulder, L Breiman, L Breiman, LA Boyer, LA Boyer, LA Boyer, M Ashburner, M Hemberger, M Shogren-Knaak, MA Beer, ME Ritchie, MG Guenther, N Ivanova, NL Vastenhouw, Olga G. Troyanskaya, P Sampath, QL Ying, R Karlić, R Lu, R Opgen-Rhein, RC Gentleman, SK Kurdistani, SK Kurdistani, SL Lauritzen, SL Schreiber, Smyth, T Hastie, TI Lee, TS Mikkelsen, TW Anderson, TY Roh, V Chickarmane, VG Allfrey, W Reik, WY Chang, Y Yuan, YH Loh, Z Wang   +70 more
core   +4 more sources

Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer

Nucleic Acids Research, 2020
MORC family CW-type zinc finger 2 (MORC2) is an oncogenic chromatin-remodeling enzyme with an emerging role in DNA repair. Here, we report a novel function for MORC2 in cell-cycle checkpoint control through an acetylation-dependent mechanism.
Hong-Yi Liu, Ying-Ying Liu, Fan Yang, Lin Zhang, Fang-Lin Zhang, Xin Hu, Z. Shao, Da-Qiang Li   +7 more
semanticscholar   +1 more source

Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members. [PDF]

PLoS ONE, 2016
Lysine acetylation has emerged as a dominant post-translational modification (PTM) regulating tau proteins in Alzheimer's disease (AD) and related tauopathies.
Andrew W Hwang, Hanna Trzeciakiewicz, Dave Friedmann, Chao-Xing Yuan, Ronen Marmorstein, Virginia M Y Lee, Todd J Cohen   +6 more
doaj   +1 more source

Acetylation of WRN protein regulates its stability by inhibiting ubiquitination. [PDF]

PLoS ONE, 2010
WRN is a multi-functional protein involving DNA replication, recombination and repair. WRN acetylation has been demonstrated playing an important role in response to DNA damage.
Kai Li, Rui Wang, Enerlyn Lozada, Wei Fan, David K Orren, Jianyuan Luo   +5 more
doaj   +1 more source

Protein acetylation in archaea, bacteria, and eukaryotes [PDF]

, 2010
Proteins can be acetylated at the alpha-amino group of the N-terminal amino acid (methionine or the penultimate amino acid after methionine removal) or at the epsilon-amino group of internal lysines.
Lainio, Jarmo, Norberg Brorsson, Birgitta   +1 more
core   +1 more source

Erasers of histone acetylation: the histone deacetylase enzymes.

Cold Spring Harbor Perspectives in Biology, 2014
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins.
E. Seto, Minoru Yoshida
semanticscholar   +1 more source

Acetylation Modification During Autophagy and Vascular Aging

Frontiers in Physiology, 2021
Vascular aging plays a pivotal role in the morbidity and mortality of elderly people. Decrease in autophagy leads to acceleration of vascular aging, while increase in autophagy leads to deceleration of vascular aging. And emerging evidence indicates that
Jiaxing Sun, Shi Tai, Liang Tang, Hui Yang, Mingxian Chen, Yichao Xiao, Xuping Li, Zhaowei Zhu, Shenghua Zhou   +8 more
doaj   +1 more source

Palladium-catalyzed acetylation of arenes. [PDF]

, 2014
A simple method for the preparation of aryl methyl ketones is reported. The transformation involves the Pd-catalyzed coupling of an acyl anion equivalent, acetyltrimethylsilane, with aryl bromides to afford the corresponding acetylated arenes in ...
Garg, Neil K, Ramgren, Stephen D
core   +1 more source