Results 31 to 40 of about 199,012 (297)

Progress of Acetylation Modification in Plants

Agronomy
Protein acetylation, a conserved post-translational modification, is collaboratively catalyzed by acetyltransferases and deacetylases and is widespread in plants.
Ruiqi Li, Xuezhong Li, Ying He, Xiaoyuan Chen, Jing Li, Chuxiong Zhuang   +5 more
doaj   +1 more source

Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease

iScience, 2020
Summary: In Alzheimer's disease (AD), decreases in the amount and synaptic localization of AMPA receptors (AMPARs) result in weakened synaptic activity and dysfunction in synaptic plasticity, leading to impairments in cognitive functions.
Margaret O'Connor, Yang-Ping Shentu, Guan Wang, Wen-Ting Hu, Zhen-Dong Xu, Xiao-Chuan Wang, Rong Liu, Heng-Ye Man   +7 more
doaj   +1 more source

Acetylation of graphite oxide

Physical Chemistry Chemical Physics, 2020
Unlike many methods of chemical modification of Graphite Oxide (GO) reported during 1930–1960 and re-studied in much detail over the last decade, acetylation somehow escaped attention and remained almost completely unexplored.
Andreas Nordenström, Artem Iakunkov, Igor Baburin, Alexandr Talyzin   +3 more
openaire   +5 more sources

Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation

Nature Communications, 2019
Many human proteins are regulated by lysine acetylation, but the degree of acetylation at individual sites is poorly characterized. Here, the authors measure acetylation stoichiometry in the HeLa cell proteome, providing a resource to assess mechanistic ...
Bogi Karbech Hansen, Rajat Gupta, Linda Baldus, David Lyon, Takeo Narita, Michael Lammers, Chunaram Choudhary, Brian T. Weinert   +7 more
doaj   +1 more source

Ancient Regulatory Role of Lysine Acetylation in Central Metabolism

mBio, 2017
Lysine acetylation is a common protein post-translational modification in bacteria and eukaryotes. Unlike phosphorylation, whose functional role in signaling has been established, it is unclear what regulatory mechanism acetylation plays and whether it ...
Ernesto S. Nakayasu, Meagan C. Burnet, Hanna E. Walukiewicz, Christopher S. Wilkins, Anil K. Shukla, Shelby Brooks, Matthew J. Plutz, Brady D. Lee, Birgit Schilling, Alan J. Wolfe, Susanne Müller, John R. Kirby, Christopher V. Rao, John R. Cort, Samuel H. Payne   +14 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Influence of N^ε-Lysine Acetylation on the Formation of Protein Aggregates and Antibiotic Persistence in E. coli

Molecules
Numerous studies indicate that reversible Nε-lysine acetylation in bacteria may play a key role in the regulation of metabolic processes, transcription and translation, biofilm formation, virulence, and drug resistance.
Karolina Stojowska-Swędrzyńska, Dorota Kuczyńska-Wiśnik, Ewa Laskowska   +2 more
doaj   +1 more source

Bromodomain Protein BRD4 Accelerates Glucocorticoid Dysregulation of Bone Mass and Marrow Adiposis by Modulating H3K9 and Foxp1

Cells, 2020
Glucocorticoid provokes bone mass loss and fatty marrow, accelerating osteoporosis development. Bromodomain protein BRD4, an acetyl–histone-binding chromatin reader, regulates stem cell and tissue homeostasis.
Feng-Sheng Wang, Yu-Shan Chen, Jih-Yang Ko, Chung-Wen Kuo, Huei-Jing Ke, Chin-Kuei Hsieh, Shao-Yu Wang, Pei-Chen Kuo, Holger Jahr, Wei-Shiung Lian   +9 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source