Results 101 to 110 of about 185,010 (296)
POTENTIATION OF THE RESPONSE OF FROG RECTUS MUSCLE TO ACETYLCHOLINE BY ISOPROPYL METHYL PHOSPHONOFLUORIDATE AND ITS MODIFICATION BY PYRIDINE‐2‐ALDOXIME METHIODIDE [PDF]
, 1958 Joseph H. Fleisher +2 more
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Artificial Enzymatic Electrochemistry
ChemElectroChem, EarlyView.Artificial enzymatic electrochemistry has emerged as an effective method to extend the catalytic abilities of enzymes. This review explores the bioelectrochemical methods used to understand and optimize the structure and function of artificial enzymes.
Nya E. Black +3 more
wiley +1 more source
Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications
Chemistry – A European Journal, EarlyView.Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju +4 more
wiley +1 more source
ChemMedChem, EarlyView.Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Miguel A. Herrera‐Rueda +4 more
wiley +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract TAK‐071 is a novel muscarinic M1 positive allosteric modulator under investigation for the treatment of cognitive impairment and falls associated with Parkinson disease (PD). This study evaluated population pharmacokinetics of TAK‐071 following single (1‐160 mg) and multiple (3‐15 mg once daily) oral‐dose TAK‐071 in 112 healthy participants ...
Hongxia Jia +8 more
wiley +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan +7 more
wiley +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Converging evidence from neuroimaging studies and genome‐wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology of anorexia nervosa (AN). However, identifying the causal role of circuit‐specific genes in the development of the AN‐like phenotype remains ...
K. Huang +7 more
wiley +1 more source
ACCUMULATION OF ACETYLCHOLINE IN BRAIN AND BLOOD OF ANIMALS POISONED WITH CHOLINESTERASE INHIBITORS [PDF]
, 1952 W. C. Stewart
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Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction
ESC Heart Failure, Volume 12, Issue 2, Page 799-808, April 2025.Abstract We performed a systematic review and meta‐analysis to detect the impact of chronic obstructive pulmonary disease (COPD) on the prognosis of heart failure patients with preserved ejection fraction (HFpEF). We systematically screened eligible literature from three electronic databases, PubMed, EMBASE and Cochrane Library, up to April 2023.
Shuo Xu +3 more
wiley +1 more source