Results 101 to 110 of about 321,644 (366)
Frontiers in Physiology, 2020 The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat.
Eilidh A. MacDonald +3 more
doaj +1 more source
Acetylcholine-modulated plasticity in reward-driven navigation: a computational study [PDF]
arXiv, 2017 Neuromodulation plays a fundamental role in the acquisition of new behaviours. Our experimental findings show that, whereas acetylcholine biases hippocampal synaptic plasticity towards depression, the subsequent application of dopamine can retroactively convert depression into potentiation.
arxiv
Conformation of acetylcholine bound to the nicotinic acetylcholine receptor. [PDF]
Proceedings of the National Academy of Sciences, 1988 We report here the biologically active conformation of acetylcholine when bound to the high-affinity state of the receptor from Torpedo californica. The acetylcholine conformation was determined in the free and bound states by proton NMR two-dimensional nuclear Overhauser effects. In agreement with x-ray crystallographic data, acetylcholine in solution
Tetsuo Yamane +3 more
openaire +3 more sources
Ultrastructural Distribution of the 7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus [PDF]
, 2001 Acetylcholine (ACh) is an important neurotransmitter in the mammalian brain; it is implicated in arousal, learning, and other cognitive functions. Recent studies indicate that nicotinic receptors contribute to these cholinergic effects, in addition to ...
Alan Fine +6 more
core +1 more source
Advanced Science, EarlyView.Mitochondria across the entire neuromuscular system have been comprehensively reconstructed at different developmental stages using 3D electron microscopy. Fundamental structural principles related to synaptic function are preserved across development, and these morphologies are adapted to ensure effective neural circuit function.
J. Alexander Bae +9 more
wiley +1 more source
Advances in electrochemical detection methods for measuring contaminants of emerging concerns
Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022 Abstract The presence of contaminants of emerging concerns (CECs) such as pharmaceuticals and personal care products, endocrine disrupting compounds (EDCs), per/poly‐fluorinated substances (PFAS), pesticides, and nanomaterials poses significant challenges to the environment and human health.
Mohamed H. Hassan +2 more
wiley +1 more source
Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex
Frontiers in Neuroanatomy, 2018 From an anatomical point of view the neocortex is subdivided into up to six layers depending on the cortical area. This subdivision has been described already by Meynert and Brodmann in the late 19/early 20.
Gabriele Radnikow +3 more
doaj +1 more source
A Computational Model of the Cholinergic Modulation of CA1 Pyramidal Cell Activity
Frontiers in Computational Neuroscience, 2020 Dysfunction in cholinergic modulation has been linked to a variety of cognitive disorders including Alzheimer's disease. The important role of this neurotransmitter has been explored in a variety of experiments, yet many questions remain unanswered about
Adam Mergenthal +3 more
doaj +1 more source
Bistable perception, precision and neuromodulation [PDF]
arXiv, 2022 Bistable perception follows from observing a static, ambiguous, (visual) stimulus with two possible interpretations. Here, we present an active (Bayesian) inference account of bistable perception and posit that perceptual transitions between different interpretations (i.e., inferences) of the same stimulus ensue from specific eye movements that shift ...
arxiv
Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]
, 2019 Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core