Results 31 to 40 of about 116,451 (242)

Acetylcholine release and inhibitory interneuron activity in hippocampal CA1

Frontiers in Synaptic Neuroscience, 2014
Acetylcholine release in the central nervous system (CNS) has an important role in attention, recall and memory formation. One region influenced by acetylcholine is the hippocampus, which receives inputs from the medial septum and diagonal band of Broca ...
A. Rory McQuiston
doaj   +1 more source

Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice

Nature Communications
Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined brain areas and
Quynh-Anh Nguyen, Peter M. Klein, Cheng Xie, Katelyn N. Benthall, Jillian Iafrati, Jesslyn Homidan, Jacob T. Bendor, Barna Dudok, Jordan S. Farrell, Tilo Gschwind, Charlotte L. Porter, Annahita Keravala, G. Steven Dodson, Ivan Soltesz   +13 more
doaj   +1 more source

The α9α10 acetylcholine receptor: A non-neuronal nicotinic receptor

Pharmacological Research, 2023
Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic receptors (nAChRs) were classically identified to mediate synaptic transmission in the nervous system and the neuromuscular junction. The α9 and α10 nAChR subunits were
Ana Belén Elgoyhen
doaj  

Erratum to: The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes

Protein & Cell, 2017
In the original publication of the article the keywords are incorrectly online published. The correct keywords should read as α-Conotoxin; Nicotinc acetylcholine receptor; Acetylcholine binding protein; X-ray crystallography”.
Manyu Xu, Xiaopeng Zhu, Jinfang Yu, Jinpeng Yu, Sulan Luo, Xinquan Wang   +5 more
doaj   +1 more source

Nicotinic α7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons [PDF]

, 2012
The tryptophan metabolite, kynurenic acid (KYNA), is classically known to be an antagonist of ionotropic glutamate receptors. Within the last decade several reports have been published suggesting that KYNA also blocks nicotinic acetylcholine receptors (nAChRs) containing the \alpha7 subunit (\alpha7*).
arxiv   +1 more source

Relaxation measurements on the acetylcholine receptor. [PDF]

Proceedings of the National Academy of Sciences, 1975
In Electrophorus electroplaques, the agonist-induced postsynaptic conductance depends on membrane potential. During steady exposure to agonists, after a voltage step the conductance relaxes on a millisecond time scale, exponentially approaching a new equilibrium value.
Sheridan, Robert E., Lester, Henry A.
openaire   +5 more sources

Anti-Kv1.4 Antibody Without Myasthenia Gravis

JACC: Case Reports, 2023
Anti-Kv1.4 antibody is often detected in thymoma-associated myasthenia gravis patients with anti-acetylcholine receptor antibody. Herein, we describe 2 patients with concurrent myocarditis and myositis.
Naoto Kuyama, MD, Seiji Takashio, MD, PhD, Takumi Nagakura, MD, Michie Imamura, MD, Koutaro Takamatsu, MD, PhD, Masafumi Takae, MD, PhD, Kyoko Hirakawa, MD, PhD, Kenshi Yamanaga, MD, PhD, Shinsuke Hanatani, MD, PhD, Eiichiro Yamamoto, MD, PhD, Kenichi Matsushita, MD, PhD, Mitsuharu Ueda, MD, PhD, Kenichi Tsujita, MD, PhD   +12 more
doaj  

Cholinergic receptor alterations in the cerebral cortex of spinal cord injured rat

Biochemistry and Biophysics Reports, 2017
Many areas of the cerebral cortex process sensory information or coordinate motor output necessary for control of movement. Disturbances in cortical cholinergic system can affect locomotor coordination.
R. Chinthu, T.R. Anju, C.S. Paulose
doaj   +1 more source

Scanning curves and kinetics of the acetylcholine / acetylcholine receptor hysteresis [PDF]

Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1988
The high affinity binding of the neurotransmitter acetylcholine (AcCh) to the nicotinic acetylcholine receptor (nAcChR) of the electric organ of Torpedo californica exhibits a pronounced hysteresis and scanning loops. Dialysis conditions lead to an equilibrium binding curve which is coincident with the upper hysteresis branch; K = 5 × 10−9M, 4° C; and ...
Neumann, Eberhard, Boldt, Elvira, Rauer, Barbara, Wolf, Hendrik, Chang, Hai Won   +4 more
openaire   +3 more sources

"Warming yang and invigorating qi" acupuncture alters acetylcholine receptor expression in the neuromuscular junction of rats with experimental autoimmune myasthenia gravis

Neural Regeneration Research, 2016
Myasthenia gravis is an autoimmune disorder in which antibodies have been shown to form against the nicotinic acetylcholine nicotinic postsynaptic receptors located at the neuromuscular junction.
Hai-peng Huang, Hong Pan, Hong-feng Wang
doaj   +1 more source