Results 101 to 110 of about 67,911 (287)

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept

Environmental Toxicology, EarlyView.
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro   +3 more
wiley   +1 more source

Unilateral mastication‐induced memory deficits linked to disrupted hippocampal cholesterol metabolism in rats

VIEW, EarlyView.
Unilateral mastication, a common oral habit, induces cognitive decline in rats by disrupting hippocampal cholesterol metabolism. It triggers astrocyte hyperplasia, enhances cholesterol synthesis, impairs transport/degradation, and reduces 24‐hydroxycholesterol (24‐OHC), ultimately damaging synaptic function.
Xiaoting Zhai, Yifan Hu, Rongchen Xu, Xinyu Xu, Bowen Ma, Dongzong Huang, Hongchen Liu, Hongbo Li, Yuan Hu, Hua Jiang   +9 more
wiley   +1 more source

Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory And Cognitive Impairment Induced By Scopolamine Via Preventing Hippocampal Cholinergic Dysfunction In Rats

Neuropsychiatric Disease and Treatment, 2019
Qiong Wu,1,2,* Yu Cao,1,* Meixia Liu,1 Fang Liu,1 Adelheid H Brantner,3 Yang Yang,1 Yun Wei,1 Yu Zhou,4 Zhiyong Wang,1 Lina Ma,1 Feixue Wang,1 Hui Pei,1 Hao Li1 1Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences ...
Wu Q, Cao Y, Liu M, Liu F, Brantner AH, Yang Y, Wei Y, Zhou Y, Wang Z, Ma L, Wang F, Pei H, Li H   +12 more
doaj  

Functional validation of a white pupae minimal gene construct in Ceratitis capitata (Diptera: Tephritidae)

Insect Science, EarlyView.
An intronless version of the white pupae (wp) gene was engineered to restore the wild type brown puparium color in white pupae phenotype mutants of the Mediterranean fruit fly, Ceratitis capitata. Functionality of the minimal gene version (mini‐wp) was verified in vivo, as one copy of mini‐wp successfully restored the wild type phenotype in homozygous ...
Lucas Henrique Figueiredo Prates, Roswitha A. Aumann, Inga Sievers, Tanja Rehling, Marc F. Schetelig   +4 more
wiley   +1 more source

Combining Deep Learning and Structural Modeling to Identify Potential Acetylcholinesterase Inhibitors from Hericium erinaceus [PDF]

Thana Sutthibutpong, Kewalin Posansee, Monrudee Liangruksa, Teerasit Termsaithong, Supanida Piyayotai, Paripok Phitsuwan, Patchreenart Saparpakorn, Supa Hannongbua, Teeraphan Laomettachit   +8 more
openalex   +1 more source

Acetylcholinesterase Immobilized on Glass Rod for Organophosphorus Pesticides Detection: Application on Milk Analysis

, 2021
Asiya Utegenova, Zhainagul Kakimova, Alexey Klivenko, Zarina Kapshakbayeva, Galiya Imankulova, Gulmira Naurzbaeva, Gulnara Tulkebayeva, Gulmira Mirasheva   +7 more
openalex   +1 more source

DsiRNA‐mediated silencing of Ceratitis capitata transformer or transformer‐2 leads to masculinization of XX embryos and systemic gene silencing in ovaries

Insect Science, EarlyView.
We carried out functional studies using Dicer‐substrate small interfering RNAs (DsiRNAs), targeting the sex determination genes Cctransformer (Cctra) and Cctransformer‐2 (Cctra‐2) in the Mediterranean fruit fly (Ceratitis capitata). Microinjection of DsiRNAs into XX embryos (0‐1 h old) rapidly triggered the expression of male‐specific Cctra isoforms ...
Gennaro Volpe, Sarah Maria Mazzucchiello, Domenico De Falco, David Torrente, Stefania Liguori, Noemi Rosati, Dora Baccaro, Michela Mazzeo, Fulvio Bertolotto, Harshini Sangle, Ennio Giordano, Angela Carfora, Francesca Lucibelli, Marianna Varone, Paola Di Lillo, Hugo Diego Perdomo, Mariangela Bonizzoni, Serena Aceto, Marco Salvemini, Molly Duman‐Scheel, Giuseppe Saccone   +20 more
wiley   +1 more source

Synthesis of α-oxycarbanilinophosphonates and their anticholinesterase activities: the most potent derivative is bound to the peripheral site of acetylcholinesterase

, 2012
Babak Kaboudin, Saeed Emadi, Mohammad Reza Faghihi, Maryam Fallahi, Vahid Sheikh‐Hasani   +4 more
openalex   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Insecticidal, Antifeedant and Acetylcholinesterase Inhibitory Activity of Sesquiterpenoids Derived from Eudesmane, Their Molecular Docking and Qsar

, 2023
Muñoz-Núñez Evelyn, Pastene-Navarrete Edgar, Quiroz-Carreño Soledad, Carlos L. Céspedes, Julio Alarcón   +4 more
openalex   +1 more source