Results 191 to 200 of about 51,436 (262)

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept

Environmental Toxicology, Volume 41, Issue 8, Page 507-522, August 2026.
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro   +3 more
wiley   +1 more source

Effect of Aerobic Exercise and a Diet Supplementation with Linoleic Acid on Metabolic Parameters in <i>Drosophila melanogaster</i>. [PDF]

Biology (Basel)
Alves THO, Silva JR, Limeira IM, Rhein S, Souza AO.   +4 more
europepmc   +1 more source

HNRNPC Succinylation Influences the Neurodegeneration of Alzheimer's Disease Through YME1L1‐Mediated Mitochondrial Metabolism

Aging Cell, Volume 25, Issue 8, August 2026.
In Alzheimer's disease, SIRT5 downregulation enhances TRIM25‐mediated succinylation of HNRNPC at K50, increasing its stability. Stabilized HNRNPC upregulates YME1L1 expression via an m6A‐dependent mechanism, leading to OPA1 hydrolysis dysregulation, mitochondrial fission‐fusion imbalance, ROS overproduction, and neuronal death.
Xuewei Li, Fan Yang, Yuyan Jiang, Fei Zhao, Fan Liu   +4 more
wiley   +1 more source

Why acetylcholinesterase inhibitors should be considered disease-modifying drugs for Alzheimer's disease? [PDF]

Aging Clin Exp Res
Zuliani G, Cervellati C, Zuin M, Brombo G.   +3 more
europepmc   +1 more source

Integrating Artificial Intelligence Into Drug Discovery From Medicinal Plants: Current Applications and Infrastructural Challenges

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This review presents a systems‐oriented roadmap for integrating artificial intelligence into medicinal plant drug discovery to overcome persistent bottlenecks like extract complexity. It highlights that advancing toward reproducible therapeutics requires making phytochemical datasets AI‐ready via rigorous harmonization and phyto‐centric foundational ...
Amit Gangwal, Azim Ansari, Mohd Usman Mohd Siddique, Jyotiram Sawale, Suhas Padmane, Raju Wadekar   +5 more
wiley   +1 more source

Topical pyridostigmine for ocular myasthenia gravis: a translational hypothesis. [PDF]

Med Hypothesis Discov Innov Ophthalmol
Ing EB, Lim K, Davies NM, Lobenberg R, Harunur Rashid M, Le TS, Rullo J.   +6 more
europepmc   +1 more source

Characterization of Usage Patterns of Drugs Suspected to Cause Adverse Drug Reactions in Older Hospitalized Patients

Geriatrics &Gerontology International, Volume 26, Issue 8, August 2026.
ABSTRACT Aim This study aimed to characterize the usage patterns of drugs suspected to cause adverse drug reactions (ADRs) in older hospitalized patients. Methods Medical records of older adults admitted to the Department of Geriatrics and Hypertension at Osaka University Hospital from September 2014 to August 2021 were reviewed.
Mizuki Katsuhisa, Shota Hamada, Chie Hamaie, Yuko Takeshita, Kasumi Ikuta, Yuichiro Saizen, Eriko Koujiya, Yoichi Takami, Koichi Yamamoto, Yasushi Takeya   +9 more
wiley   +1 more source

Cholinergic Crisis Associated With Standard-Dose Pyridostigmine in a Hemodialysis Patient With Ocular Myasthenia Gravis and Marked Weight Loss. [PDF]

Cureus
Junki K, Nozaki Y, Miyake K.
europepmc   +1 more source

Impact of Environmental Exposure on Infant Sleep : The Exposome Approach

Journal of Sleep Research, Volume 35, Issue 4, August 2026.
This review explores how exposure to environmental pollutants during the first 1000 days of life may affect infant sleep. Evidence suggests potential links between chemical exposures and sleep disturbances, underscoring the need for more research on early‐life vulnerability and the impact of pollutants in air, diet, and breast milk.
Zeina Halbouty, Debora Tuka, Erwan Stephan‐Blanchard, Veronique Bach, Pierre Tourneux, Elodie Haraux, Karen Chardon   +6 more
wiley   +1 more source

Cognitive training, alone and combined with acetylcholinesterase inhibitors, in neurocognitive disorders: long-term efficacy and the role of cognitive reserve on 30 months of intervention. [PDF]

Alzheimers Dement (N Y)
Ravelli A, Ceolin C, De Rui M, Coin A, Sergi G, Mapelli D, Devita M.   +6 more
europepmc   +1 more source