Results 241 to 250 of about 133,708 (320)

Analysis of the forms of acetylcholinesterase from adult mouse brain [PDF]

open access: green, 1975
Eileen D. Adamson   +3 more
openalex   +1 more source

Toward Novel Targeted Therapy for Overactive Bladder: A Cadaver Study Identifying Critical Autonomic Nerve Structures

open access: yesNeurourology and Urodynamics, Volume 44, Issue 8, Page 1695-1703, November 2025.
ABSTRACT Introduction and Objectives Targeted radiofrequency (RF) therapy is a promising treatment for overactive bladder (OAB), aiming to modulate autonomic nerve pathways for symptom control. This cadaveric study focuses on identifying areas of high nerve density in the bladder and corresponding vaginal wall (AVW) to support RF use in a minimally ...
Gamal Ghoniem   +2 more
wiley   +1 more source

Research progress of exosomes used in the Alzheimer's disease treatment. [PDF]

open access: yesDiscov Nano
Gao X   +5 more
europepmc   +1 more source

RENSHAW ELEMENTS: LOCALIZATION AND ACETYLCHOLINESTERASE CONTENT

open access: bronze, 1968
S. D. Erulkar   +3 more
openalex   +1 more source

Ligand binding Pro‐miscuity of acylpeptide hydrolase, structural analysis of a detoxifying serine hydrolase

open access: yesProtein Science, Volume 34, Issue 11, November 2025.
Abstract Acylpeptide hydrolase (APEH) or acylaminoacyl‐peptidase (AAP) is a serine hydrolase that regulates protein metabolism. It can also bind to and process unusual substrates, acting as a detoxifier. To better understand its promiscuous specificity, we determined the cryo‐EM structures of mammalian APEH complexed with classical serine protease ...
Anna J. Kiss‐Szemán   +8 more
wiley   +1 more source

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 22, Page 5574-5595, November 2025.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto   +16 more
wiley   +1 more source

Computer-aided discovery of dual-target compounds for Alzheimer's from ayurvedic medicinal plants. [PDF]

open access: yesPLoS One
Shah M   +10 more
europepmc   +1 more source

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