Results 251 to 260 of about 67,911 (287)

Acetylcholinesterase

Angewandte Chemie International Edition in English, 1967
AbstractAcetylcholinesterase plays a vital part in the functioning of nerves, and serious physiological damage arises from its blockage by esters of phosphonic and phosphoric acid used e. g. in pesticides. The properties and the mechanism of action of acetylcholinesterase, which show many similarities to those of other hydrolases, are described ...
N, Engelhard, K, Prchal, M, Nenner
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Acetylcholinesterase kinetics

Biophysics of Structure and Mechanism, 1980
Three mechanisms have been suggested to describe the inhibition of acetylcholinesterase (EC. 3.1.1.7) by an excess of acetylcholine. (i) Substrate inhibition occurs through the reaction of acetylcholine with acetylated enzyme. The deacetylation of this ternary complex is supposed to be completely inhibited.
P, Hofer, U P, Fringeli
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Breathing Without Acetylcholinesterase

2004
Acetylcholine (ACh) mediates neurotransmission at the neuromuscular junction and is involved in respiratory control1, notably chemosensitivity2 of central and peripheral origin. The level of ACh at the synaptic cleft and neuromuscular junction is regulated by the enzyme acetylcholinesterase (AChE).
Chatonnet, Fabrice, Boudinot, Eliane, Chatonnet, Arnaud, Champagnat, Jean, Foutz, Arthur   +4 more
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ACETYLCHOLINESTERASE

Canadian Journal of Biochemistry, 1964
The general characteristics of acetylcholinesterase are described. The mechanism of action of the enzyme is considered primarily in relation to the two steps in the hydrolysis of acetylcholine, the acetylation and deacetylation reactions. Competitive and non-competitive inhibition, and inhibitions by hydrogen ion and by substrate, are explained in ...
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Tetrahydrocannabinol and acetylcholinesterase

Pharmacology Biochemistry and Behavior, 1978
Recent evidence suggests that the psychoactive effect of delta-9-tetrahydrocannabinol (delta9-THC), the major psychoactive constituent of marihuana, may be mediated through an alteration of cholinergic neurotransmission. One possible mechanism by which delta9-THC could have its effect is by affecting acetylcholinesterase (AChE) and there is evidence ...
D E, Moss, P L, Peck, R, Salome
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Plasma acetylcholinesterase activity

American Journal of Obstetrics and Gynecology, 1950
Abstract ChE activity in plasma from normal adult nonmenstruating, nonpregnant women, from women during normal pregnancy, and from patients with toxemia of pregnancy was determined manometrically. Significant differences were observed among the three groups. This difference was independent of medication (Sodium Amytal), and could not be attributed to
W W, TOURTELLOTTE, L D, ODELL
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Molecular Dynamics of Acetylcholinesterase

Accounts of Chemical Research, 2002
Molecular dynamics simulations are leading to a deeper understanding of the activity of the enzyme acetylcholinesterase. Simulations have shown how breathing motions in the enzyme facilitate the displacement of substrate from the surface of the enzyme to the buried active site.
Shen, Tongye, Tai, Kaihsu, Henchman, Richard H., McCammon, J. Andrew   +3 more
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