Serum cholinesterases are differentially regulated in normal and dystrophin-deficient mutant mice
Frontiers in Molecular Neuroscience, 2012 The cholinesterases, acetylcholinesterase and butyrylcholinesterase (pseudocholinesterase), are abundant in the nervous system and in other tissues. The role of acetylcholinesterase in terminating transmitter action in the peripheral and central nervous ...
Andrea R. Durrant +2 more
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N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor [PDF]
, 2014 On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which ...
Agbaba, D. +13 more
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New substrates of acetylcholinesterase [PDF]
FEBS Letters, 1981 Volume 134, number 1 FEBS LETTERS November 1981 NEW SUBSTRATES OF ACETYLCHOLINESTERASE Meira NAVEH, Zmira BERNSTEIN, Dina SEGAL and Yechiel SHALITIN* Department of Biology, Technion-Israel Institute of Technology, Haifa, 32000, Israel Received 2 September 1981 1.
Dina Segal +3 more
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Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention
Biomolecules, 2020 This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare ...
Samir F. de A. Cavalcante +7 more
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Biological activities of ethanolic extracts from deep-sea antarctic marine sponges [PDF]
, 2013 We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth ...
Ambrožič Avguštin, Jerneja +9 more
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Binding of acetylcholinesterases to concanavalin A [PDF]
FEBS Letters, 1974 Acetylcholinesterases from a number of different sources are known to be glycoproteins. Carbohydrate residues were found in the eel enzyme [ 1,2] , human erythrocyte acetylcholinesterase [3 ] torpedo California [4] plaice cholinesterase [ 51 and the cholinesterases from human serum [6,7], horse serum [8,9] and human brain [lo]. It was of interest to us
R. Gentinetta +2 more
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Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics
Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023 Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar +2 more
wiley +1 more source
The European Zoological Journal, 2021 Pesticides are frequently applied to agricultural activities to improve harvest, in terms of yield and product quality. Useful tools for ecotoxicological studies of marine ecosystems are based on biomarker application on bioindicator key fish species ...
V. Parrino +8 more
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On the excitation of action potentials by protons and its potential implications for cholinergic transmission [PDF]
, 2014 One of the most conserved mechanisms for transmission of a nerve pulse across a synapse relies on acetylcholine. Ever since the Nobel-prize winning works of Dale and Loewi, it has been assumed that acetylcholine - subsequent to its action on a postsynaptic cell - is split into inactive by-products by acetylcholinesterase.
arxiv +1 more source
Dysregulated homeostasis of acetylcholine levels in immune cells of RR-multiple sclerosis patients [PDF]
, 2016 Multiple sclerosis (MS) is characterized by pro-inflammatory cytokine production. Acetylcholine (ACh) contributes to the modulation of central and peripheral inflammation.
Biagioni, Stefano +11 more
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