Results 51 to 60 of about 129,904 (253)

Bacopa monnieri: A promising herbal approach for neurodegenerative disease treatment supported by in silico and in vitro research

Heliyon, 2023
Neurodegenerative disorders, caused by progressive neuron loss, are a global health issue. Among the various factors implicated in their pathogenesis, dysregulation of acetylcholinesterase activity has been recognized as a key contributor ...
Shehla Shoukat, Muhammad Amir Zia, Muhammad Uzair, Kotb A. Attia, Asmaa M. Abushady, Sajid Fiaz, Shaukat Ali, Seung Hwan Yang, Ghulam Muhammad Ali   +8 more
doaj  

Searching for potential acetylcholinesterase inhibitors: a combined approach of multi-step similarity search, machine learning and molecular dynamics simulations

Royal Society Open Science
Targeting acetylcholinesterase is one of the most important strategies for developing therapeutics against Alzheimer’s disease. In this work, we have employed a new approach that combines machine learning models, a multi-step similarity search of the ...
Quynh Mai Thai, Minh Quan Pham, Phuong-Thao Tran, Trung Hai Nguyen, Son Tung Ngo   +4 more
doaj   +1 more source

Occurrence of target-site resistance to neonicotinoids in the aphid Myzus persicae in Tunisia, and its status on different host plants [PDF]

, 2018
This is the peer reviewed version of the following article: Kamel Charaabi, Sonia Boukhris-bouhachem, Mohamed Makni, and Ian Denholm, ‘Occurrence of target‐site resistance to neonicotinoids in the aphid Myzus persicae in Tunisia, and its status on ...
Bass, Bass, Bass, Bass, Black, Blackman, Blackman, Blackman, Charaabi, Devonshire, Fekih Hassen, Field, Fontaine, Ilias, Katis, Little, Margaritopoulos, Martinez-Torres, Moores, Mottet, Nabeshima, Panini, Puinean, Puinean, Raboudi, Slater, Vorburger, Vorburger, Voudouris   +28 more
core   +2 more sources

Resistance status of the carmine spider mite, Tetranychus cinnabarinus and the twospotted spider mite, Tetranychus urticae to selected acaricides on strawberries. [PDF]

, 2015
The carmine spider mite, Tetranychus cinnabarinus (Boisduval) and the twospotted spider mite, Tetranychus urticae Koch, are serious pests of strawberries and many other horticultural crops.
Bi, Jian-Long, Niu, Zi-Mian, Toscano, Nick C, Yu, Lu   +3 more
core   +1 more source

A rapid in vitro assay for evaluating the effects of acetylcholinesterase inhibitors and reactivators in the rat basolateral amygdala

Frontiers in Cellular Neuroscience, 2022
We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE) reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) dependent hyperexcitability observed after exposure to the organophosphate (OP ...
Jeffrey S. Thinschmidt, Scott W. Harden, Michael A. King, James D. Talton, Charles J. Frazier   +4 more
doaj   +1 more source

Acetylcholinesterase inhibition ameliorates retinal neovascularization and glial activation in oxygen-induced retinopathy [PDF]

International Journal of Ophthalmology, 2020
AIM: To investigate whether inhibition of acetylcholinesterase (AChE) by donepezil ameliorate aberrant retinal neovascularization (RNV) and abnormal glial activation in oxygen-induced retinopathy (OIR).
Qiu-Ping Liu, Xian Zhang, Ya-Zhou Qin, Jing-Lin Yi, Jing-Ming Li   +4 more
doaj   +1 more source

Design, synthesis and biological evaluation of 1,3-dihydroxyxanthone derivatives: Effective agents against acetylcholinesterase [PDF]

, 2017
The present work concerns the rational design and development of new inhibitors of acetylcholinesterase (AChE) based on the privileged xanthone scaffold.
Accordino, Sebastian Roberto, Appignanesi, Gustavo Adrian, Biscussi, Brunella, Gerbino, Darío César, Menéndez, Cintia Anabella, Murray, Ana Paula   +5 more
core   +1 more source

DNA Damaging Effects, Oxidative Stress Responses and Cholinesterase Activity in Blood and Brain of Wistar Rats Exposed to Δ⁹-Tetrahydrocannabinol

Molecules, 2019
Currently we are faced with an ever-growing use of Δ9-tetrahydrocannabinol (THC) preparations, often used as supportive therapies for various malignancies and neurological disorders.
Nevenka Kopjar, Nino Fuchs, Suzana Žunec, Anja Mikolić, Vedran Micek, Goran Kozina, Ana Lucić Vrdoljak, Irena Brčić Karačonji   +7 more
doaj   +1 more source

Synaptic transmission as a cooperative phenomenon in confined systems [PDF]

, 2017
In this review paper, the theory of synaptic transmission (ST) was developed and discussed. We used the hypothesis of isomorphism between: (a) the cooperative behavior of mediators --- acetylcholine molecules (ACh) and cholinoreceptors in a synaptic ...
Chalyi, A. V., Vasilev, A. N., Zaitseva, E. V.   +2 more
core   +2 more sources

Prospective Application of Two New Pyridine-Based Zinc (II) Amide Carboxylate in Management of Alzheimer’s Disease: Synthesis, Characterization, Computational and in vitro Approaches

Drug Design, Development and Therapy, 2021
Rehman Zafar,1,2 Humaira Naureen,3 Muhammad Zubair,4 Khadija Shahid,1 Muhammad Saeed Jan,5 Samar Akhtar,2 Hammad Ahmad,2 Wajeeha Waseem,6 Ali Haider,4 Saqib Ali,4 Muhammad Tariq,7 Abdul Sadiq8 1Department of Pharmaceutical Chemistry, Faculty of ...
Zafar R, Naureen H, Zubair M, Shahid K, Saeed Jan M, Akhtar S, Ahmad H, Waseem W, Haider A, Ali S, Tariq M, Sadiq A   +11 more
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