Results 71 to 80 of about 176,476 (335)

Nanozymes at the Bio‐Nano Interface: From Synthesis, Defect Engineering, Catalytic Behavior in Biological Microenvironments, and Biosafety Implications

Advanced Materials Interfaces, EarlyView.
Nanozymes (NZs) have emerged as versatile artificial enzymes with tunable catalytic properties driven by atomic coordination, defect engineering, and surface chemistry. This review presents a bio–nano interface framework linking synthesis strategies, structural design, and catalytic behavior within complex biological microenvironments.
Karen Guadalupe Quintero‐Garrido, Aída Jimena Velarde‐Salcedo, Alejandro López‐Amador, Noé Arjona, Citlali Uitz Toalá, Carmen Gonzalez, Beatriz Liliana España‐Sánchez   +6 more
wiley   +1 more source

Anticholinergic and antioxidant activities of avocado (Folium perseae) leaves – phytochemical content by LC-MS/MS analysis

International Journal of Food Properties, 2020
In the first stage of the manuscript, we aimed to examine antioxidant capacity and anticholinergic properties of avocado (Folium perseae) leaves. Avocado leaf was extracted by water (WEFP) and ethyl alcohol (EEFP) and antioxidant activity was determined ...
Leyla Polat Kose, Zeynebe Bingol, Ruya Kaya, Ahmet C. Goren, Hulya Akincioglu, Lokman Durmaz, Ekrem Koksal, Saleh H. Alwasel, İlhami Gülçin   +8 more
doaj   +1 more source

LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)

Molecules, 2021
Kınkor (Ferulago stellata) is Turkish medicinal plant species and used in folk medicine against some diseases. As far as we know, the data are not available on the biological activities and chemical composition of this medicinal plant. In this study, the
Hatice Kızıltaş, Zeynebe Bingol, Ahmet Ceyhan Gören, Leyla Polat Kose, Lokman Durmaz, Fevzi Topal, Saleh H. Alwasel, İlhami Gulcin   +7 more
doaj   +1 more source

Acetylcholinesterase Involvement in Apoptosis [PDF]

Frontiers in Molecular Neuroscience, 2012
To date, more than 40 different types of cells from primary cultures or cell lines have shown AChE expression during apoptosis and after the induction apoptosis by different stimuli. It has been well-established that increased AChE expression or activity is detected in apoptotic cells after apoptotic stimuli in vitro and in vivo, and AChE could be ...
Zhang, Xue-Jun, Greenberg, David S.
openaire   +3 more sources

Neuromorphic Motor Control with Electrolyte‐Gated Organic Synaptic Transistors

Advanced Electronic Materials, EarlyView.
Electrolyte‐gated organic synaptic transistor (EGOST)‐based neuromorphic motor control systems integrate sensing, processing, and actuation by mimicking biological synapses. With advantages such as low power consumption, tunable synaptic plasticity, and mechanical flexibility, they are emerging as next‐generation core technologies for real‐time ...
Sung‐Hwan Kim, Ju‐Hyeok Yun, Hea‐Lim Park, Sin‐Hyung Lee   +3 more
wiley   +1 more source

Anticholinesterase Activities of Different Solvent Extracts of Brewer’s Spent Grain

Foods, 2021
Cholinesterases, involved in acetylcholine catabolism in the central and peripheral nervous system, have been strongly linked with neurodegenerative diseases. Current therapeutic approaches using synthetic drugs present several side effects. Hence, there
Rares I. Birsan, Peter Wilde, Keith W. Waldron, Dilip K. Rai   +3 more
doaj   +1 more source

Design, synthesis and biological evaluation of 1,3-dihydroxyxanthone derivatives: Effective agents against acetylcholinesterase [PDF]

, 2017
The present work concerns the rational design and development of new inhibitors of acetylcholinesterase (AChE) based on the privileged xanthone scaffold.
Accordino, Sebastian Roberto, Appignanesi, Gustavo Adrian, Biscussi, Brunella, Gerbino, Darío César, Menéndez, Cintia Anabella, Murray, Ana Paula   +5 more
core   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

CSF Cholinergic Index, a New Biomeasure of Treatment Effect in Patients With Alzheimer’s Disease

Frontiers in Molecular Neuroscience, 2019
Alzheimer’s disease (AD) is a progressive disease with early degeneration of the central cholinergic neurons. Currently, three of four AD drugs act by inhibiting the acetylcholine (ACh) degrading enzyme, acetylcholinesterase (AChE).
Azadeh Karami, Maria Eriksdotter, Maria Eriksdotter, Ahmadul Kadir, Ahmadul Kadir, Ove Almkvist, Agneta Nordberg, Agneta Nordberg, Taher Darreh-Shori   +8 more
doaj   +1 more source

A Comprehensive Review of Cholinesterase Modeling and Simulation

Biomolecules, 2021
The present article reviews published efforts to study acetylcholinesterase and butyrylcholinesterase structure and function using computer-based modeling and simulation techniques.
Danna De Boer, Nguyet Nguyen, Jia Mao, Jessica Moore, Eric J. Sorin   +4 more
doaj   +1 more source