Results 81 to 90 of about 133,708 (320)

A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. Methods Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts—AD and a transgenic mouse model—to
Susan A. Greenfield, Gregory M. Cole, Clive W. Coen, Sally Frautschy, Ram P. Singh, Marisa Mekkittikul, Sara Garcia‐Ratés, Paul Morrill, Owen Hollings, Matt Passmore, Sibah Hasan, Nikisha Carty, Silvia Bison, Laura Piccoli, Renzo Carletti, Stephano Tacconi, Anna Chalidou, Matthew Pedercini, Tim Kroecher, Hubert Astner, Philip A. Gerrard   +20 more
doaj   +1 more source

Impact of Insecticides at Sublethal Concentrations on the Enzyme Activities in Adult Musca domestica L.

Toxics, 2023
Nowadays, the use of pesticides is, as before, the most common way to control arthropod plant pests and the ectoparasites of animals. The sublethal effects of pesticides on insects can appear at different levels, from genetics to populations, and the ...
Anna Kinareikina, Elena Silivanova
doaj   +1 more source

Pesticide Exposure Alters Follicle-Stimulating Hormone Levels in Mexican Agricultural Workers [PDF]

, 2005
Organophosphorous pesticides (OPs) are suspected of altering reproductive function by reducing brain acetylcholinesterase activity and monoamine levels, thus impairing hypothalamic and/or pituitary endocrine functions and gonadal processes. Our objective
Baldi I, Butler AM, Guadalupe Ocampo-Gómez, Javier Morán-Martínez, Luisa Torres-Sánchez, Malaquías López-Cervantes, Mariano E. Cebrián, Marisela Uribe, Murray M, Nag M, Rogelio Recio, Spassova D, Victor Borja-Aburto   +12 more
core   +2 more sources

Stabilizing Stretchable Organic Transistors Through Small‐Molecule Additive Blending for Ultra‐Sensitive Pesticide Detection

Advanced Science, EarlyView.
This study introduces a small‐molecule additive to improve the stability of stretchable organic field‐effect transistor (OFET). Furthermore, stretchable OFET‐based pesticide sensors with extended‐gate electrodes are constructed. It achieves highly sensitive and precise detection of chlorpyrifos pesticide, reaching a detection limit as low as 0.032 ppb.
Weiyu Wang, Liya Dai, Xiangxiang Li, Xiaoying Zhang, Huiqi Yang, Xinran Zheng, Yan Wang, Xin Ye, Hui Yang, Wenping Hu   +9 more
wiley   +1 more source

Enzyme Immobilization by Hydrogen‐Bonded Organic Framework for the Construction of Plant‐Wearable Sensor

Advanced Science, EarlyView.
By modulating the charge of acetylcholinesterase, it is encapsulated within HOF materials, thereby enhancing its stability and maintaining its activity. Subsequently, the composite material is embedded in a glycerol‐sodium alginate gel, achieving the long‐term monitoring of pesticides.
Hongxia Li, Xiangyu Liu, Changshun Su, Xiaoguang Zhang, Chunyan Sun, Xu Yan   +5 more
wiley   +1 more source

Inhibitory effect of acetylcholinesterase and caspase activity of human breast cancer cells (MCF-7) treated with filtered extracts of the sea anemone oral disk (Stichodactyla haddoni) [PDF]

بوم‌شناسی آبزیان, 2018
The present study investigated the inhibitory effects of the oral disk extract of sea anemone, Stichodactlya haddoni on acetylcholinesterase and caspase activity.
Leila Yavari, Behrooz Heidari, Saber Khodabandeh, Hosein Ghafori, Mahvash Hadavi   +4 more
doaj  

Cholinesterase Enzymes Inhibitors from the Leaves of Rauvolfia Reflexa and Their Molecular Docking Study

Molecules, 2013
Plants of the Apocynaceae family have been traditionally used in the treatment of age-related brain disorders. Rauvolfia reflexa, a member of the family, has been used as an antidote for poisons and to treat malaria.
Vikneswaran Murugaiyah, Alireza Basiri, A. Hamid A. Hadi, Yalda Kia, Mehran Fadaeinasab   +4 more
doaj   +1 more source

Structure-activity relationship and in silico study of unique bi-heterocycles: 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole-2-thiol derivatives [PDF]

Journal of the Serbian Chemical Society, 2019
This paper presents the synthesis of some unique bi-heterocyclic hybrid molecules with a thiazole and an oxadiazole ring. The synthesis was initiated by the conversion of ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate (1) to the corresponding 2-(2-amino-1,3 ...
Abbasi Muhammad Athar, Ramzan Muhammad Shahid, Aziz-Ur-Rehman, Siddiqui Sabahat Zahra, Hassan Mubashir, Raza Hussain, Shah Syed Adnan Ali, Mirza Bushra, Seo Sung-Yum   +8 more
doaj   +1 more source

Neuromorphic Motor Control with Electrolyte‐Gated Organic Synaptic Transistors

Advanced Electronic Materials, EarlyView.
Electrolyte‐gated organic synaptic transistor (EGOST)‐based neuromorphic motor control systems integrate sensing, processing, and actuation by mimicking biological synapses. With advantages such as low power consumption, tunable synaptic plasticity, and mechanical flexibility, they are emerging as next‐generation core technologies for real‐time ...
Sung‐Hwan Kim, Ju‐Hyeok Yun, Hea‐Lim Park, Sin‐Hyung Lee   +3 more
wiley   +1 more source

Insecticidal and Nematicidal Activities of Novel Mimosine Derivatives

Molecules, 2015
Mimosine, a non-protein amino acid, is found in several tropical and subtropical plants, which has high value for medicine and agricultural chemicals.
Binh Cao Quan Nguyen, Jamnian Chompoo, Shinkichi Tawata   +2 more
doaj   +1 more source