Results 91 to 100 of about 83,041 (240)

Jujuboside B Induces Ferroptosis and Overcomes Radioresistance Through the PPARγ‐ATF3‐Gpx4 Signaling Pathway in Non‐Small Cell Lung Cancer

Phytotherapy Research, EarlyView.
Jujuboside B induces ferroptosis and overcomes radioresistance. ABSTRACT Jujuboside B (JJB) is a saponin extracted from the Ziziphus jujuba var. spinose and has been reported to have anticancer effects. However, the detailed mechanism of its anti‐cancer effect in non‐small cell lung cancer (NSCLC) remains unclear.
Tae Woo Kim, Seong‐Gyu Ko
wiley   +1 more source

Asthma associated with N-acetylcysteine infusion and paracetamol poisoning [PDF]

, 1984
L. F. Prescott, Julia Critchley
openalex   +1 more source

Letter to the Editor, ‘Haemodynamic consequences of acute pulmonary embolism predict risk of CTPA‐related acute kidney injury’

ESC Heart Failure, EarlyView.
Ahmed Raza, Shahzadi Gulfishan
wiley   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. [PDF]

, 2019
People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as young adults.
Boss, Gerry R, Casteel, Darren E, Dalton, Nancy D, Gu, Yusu, Kalyanaraman, Hema, Lee, Seunghoe, Makino, Ayako, Milewicz, Dianna M, Patel, Hemal H, Peterson, Kirk L, Pilz, Renate B, Schilling, Jan M, Schwaerzer, Gerburg K, Wahwah, Nisreen, Zhang, Qian, Zhuang, Shunhui   +15 more
core   +1 more source

Reversal of the Adverse Chronic Effects of the Unsaturated Derivative of Valproic Acid—2-n-Propyl-4-Pentenoic Acid—on Ketogenesis and Liver Coenzyme A Metabolism by a Single Injection of Pantothenate, Carnitine, and Acetylcysteine in Developing Mice [PDF]

, 1993
Jean Holowach Thurston, Richard E. Hauhart   +1 more
openalex   +1 more source

Recent Advances in Homogeneous Catalysis with Platinum Group Pincer Complexes: Hydrogen‐Mediated Transformations and Cross‐Coupling Reactions

The Chemical Record, EarlyView.
Platinum group pincer complexes are highly efficient catalysts. Additionally, their high activity enables challenging transformations with low catalyst loading. Herein, we summarize the most relevant advances of catalysis involving platinum group pincer complexes. The use of pincer complexes based on platinum group metals is undoubtedly one of the most
Juan S. Serrano‐García, Andrés Amaya‐Flórez, Jordi R.‐Galindo, Adrián Ruíz‐Martínez, David Morales‐Morales   +4 more
wiley   +1 more source

Pan‐ERBB Inhibitors Synergize With KRAS Inhibitors in Rectal Cancer

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background Emerging RAS inhibitors show promise in treating KRAS‐mutated malignancies, but resistance mechanisms limit their clinical efficacy. Given recent clinical findings associating KRAS mutations with reduced response to neoadjuvant therapy in rectal cancer (RC), we aimed to investigate their impact on treatment outcomes and explore ...
Jonas Buchloh, Melanie Spitzner, Hauke Zimmermann, Xin Fang, Constanza Tapia Contreras, Carolin Schneider, Tiago de Oliveria, Stefan Küffer, Michael Linnebacher, Felix Rühlmann, Lena Conradi, Matthias Wirth, Michael Ghadimi, Marian Grade, Jochen Gaedcke, Günter Schneider   +15 more
wiley   +1 more source

Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS), a complex inflammatory disease with heterogeneous pathogenesis, demands evolving evidence‐based strategies. Since the 2018 Chinese guidelines and EPOS2020, international advances in CRS immunopathology and biologics have revolutionized therapeutic approaches, particularly through phenotype–endotype classification ...
Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association   +4 more
wiley   +1 more source

The alcohol cue‐exposure paradigm as a screening tool for alcohol use disorder medication development: A critical review

Alcohol, Clinical and Experimental Research, EarlyView.
The alcohol cue‐exposure paradigm has a long history in alcohol use disorder (AUD) research. This review examined the paradigm's utility as a screening tool for AUD medication development and offers recommendations for its refinement. In summary, while the alcohol cue‐exposure paradigm has a strong foundation in AUD pharmacotherapy research, its future
Dylan E. Kirsch, Erica N. Grodin, Lorenzo Leggio, Sherry A. McKee, Lindsay R. Meredith, Ethan H. Mereish, Robert Miranda Jr, Steven J. Nieto, Stephanie S. O'Malley, Joseph P. Schacht, Lara A. Ray   +10 more
wiley   +1 more source