Results 111 to 120 of about 83,041 (240)

Antimicrobial prescribing guidelines for horses in Australia

Australian Veterinary Journal, EarlyView.
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt, K Thomas, S Page, J Norris, G Browning, C El Hage, A Stewart, J Gilkerson, G Muscatello, D Verwilghen, G van Galen, J Bauquier, R Cuming, B Reynolds, C Whittaker, E Wilkes, J Clulow, C Burden, L Begg   +18 more
wiley   +1 more source

N-acetylcysteine administration in the critically ill [PDF]

, 1999
Timothy Walsh, A. Lee
openalex   +1 more source

Effects of N-acetylcysteine on tissue oxygenation in patients with multiple organ failure and evidence of tissue hypoxia [PDF]

, 1997
AG Agusti, Bernat Togores, Jorge E. Ibáñez, JM Raurich, A. Maimó, Jaume Bergadá, P. Marsé, R. Gosálvez Jordá   +7 more
openalex   +1 more source

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

British Journal of Pharmacology, EarlyView.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj, Saadet Inan, Guo‐Hua Bi, Sonita Wiah, George Adamson, Allen B. Reitz, Zheng‐Xiong Xi, Scott M. Rawls   +7 more
wiley   +1 more source

More on Interference of N-Acetylcysteine in Measurement of Acetaminophen [PDF]

, 1998
Michael Mayer, Lea Salpeter
openalex   +1 more source

ROS‐Driven PKCζ Signaling as a Widely Involved Mechanism for Cancer Cell Motility and Metastasis

Cancer Science, EarlyView.
This study reveals that the enhancement of cancer cell motility by diverse bioactive molecules—including growth factors, hormones, and tissue factors—is mediated through a common intracellular mechanism involving reactive oxygen species (ROS) and the PKCζ/Rho GTPase signaling pathway.
Yasushi Sato, Maki Tanaka, Naoko Kitamura, Naoko Araki, Wataru Kurata, Akiko Sasaki, Yukimi Seo, Kageaki Kuribayashi, Shuzo Kobayashi, Yoshiro Niitsu   +9 more
wiley   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

Cell Proliferation, EarlyView.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie, Yu Wang, Wenjie Cheng, Minbo Yan, Kunyu Li, Xiang Wu, Jiaqing Wu, Zhuangzhuang Zhang, Yingbo Dai   +8 more
wiley   +1 more source

Systemic immunomodulating therapies for epidermal necrolysis (Stevens‐Johnson syndrome/toxic epidermal necrolysis): A systematic review and meta‐analysis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Epidermal necrolysis is a rare but severe cutaneous reaction with high mortality. Limited evidence exists regarding the efficacy of systemic immunomodulatory therapies (SITs). Our systematic review aimed to compare SITs with supportive care or one another.
Ruben Heuer, Maren Paulmann, Maja Mockenhaupt, Alexander Nast   +3 more
wiley   +1 more source

Clinical Application of 3% N-Acetylcysteine Collyrium on Canine Corneal Deseases

, 1993
金尾 滋, 上月 茂和, 鶴野 光興, 榎本 浩文, 桑原 康人, Yoshihisa YAMANE   +5 more
openalex   +2 more sources