Results 111 to 120 of about 88,160 (292)

A look inside the association codeine-paracetamol: clinical pharmacology supports analgesic efficacy [PDF]

, 2015
Acute and chronic pain often requires a multimodal approach. Combination therapy reduces the number of individual daily administrations and improves patient's compliance with the prescribed analgesic treatment. Despite the association codeine/paracetamol
COLUZZI, FLAMINIA, MATTIA, Consalvo
core  

Four patients with a history of acute exacerbations of COPD: implementing the CHEST/Canadian Thoracic Society guidelines for preventing exacerbations [PDF]

, 2015
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if ...
A Singanayagam, AJ Crockett, AL Ries, AM Yohannes, C Fletcher, CE Bucknall, CM Fletcher, CP Hersh, D Brooks, DD Marciniuk, F Maltais, FA Cleutjens, G Guyatt, GJ Criner, J Chong, J Pynoos, J Strijbos, JJ Soler-Cataluna, JW Dodd, K Gruffydd-Jones, K Rockwood, K Rockwood, KH Groenewegen, L Cheyne, L Lahousse, L Puente-Maestu, LP Fried, LS Bickford, M Guell, M Stickland, M Zwerink, MM Ball, P Almagro, PG Gibson, PW Jones, S Hull, SK Park, SP Newman, T Bodenheimer, T Lee, TM Wilkinson, VS Fan, World Health Organization, Y Lacasse   +43 more
core   +1 more source

The Effect of N-acetylcysteine on Periodontitis: A mini-review of literature

, 2021
André dos Santos Carvalho, Even Herlany Pereira Alves, Mateus Cardoso do Amaral, Hélio Mateus Silva Nascimento, Ayane Araújo Rodrigues, Vinícius da Silva Caetano, Ana Clara Silva Sales, Thaís Amanda de Lima Nunes, Wesley Rodrigues da Silva, John Arlley Sousa Pinho de Lira, Paulo Roberto Carneiro Gomes, Francisco Alex da Rocha Coelho, João Paulo Araújo de Sousa, Jacks Renan Neves Fernandes, Daniel Fernando Pereira Vasconcelos   +14 more
openalex   +2 more sources

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

Effects of hyperbaric oxygen and N-acetylcysteine in survival of random pattern skin flaps in rats

Indian Journal of Plastic Surgery, 2012
Objective: Our aim is to investigate the role of HBO (hyperbaric oxygen), NAC (N-acetylcysteine), and HBO plus NAC on the necrosis area of random rat′s skin flaps of a modified McFarlane flap design.
Fernando da Rocha, Djalma Fagundes, Jefferson Pires, Fernanda Salim da Rocha   +3 more
doaj   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Alterations in serum amino acid concentrations in dogs with protein-losing enteropathy [PDF]

, 2018
BackgroundCertain amino acids are decreased in humans with inflammatory bowel disease (IBD) and supplementation with the same amino acids has shown beneficial effects in animal models of IBD.
Allenspach, Beeken, Bettenworth, Clayton, Coburn, Dąbrowski, Gupta, Hashimoto, Hou, Kim, Kim, Li, Liu, Liu, Middleton, Morgan, Nikolaus, Ren, Richard, Ruth, Schrocksnadel, Tsune, Walser, Wang, Widner, Xin   +25 more
core   +4 more sources

NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression

Advanced Science, EarlyView.
NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu, Jixin Ma, Minwei Zhou, Xiaodong Gu, Yiming Zhou, Zhenyang Li, Tianyu Zhang, Wei Gong, Chuanxin Huang, Jianbin Xiang   +9 more
wiley   +1 more source

Cough in children with acute respiratory infections: to treat or not to treat?

Лечащий Врач, 2021
The article discusses the methods of therapeutic influence in the case of transport disorders and improvement of the drainage functions of the respiratory tract in acute respiratory infections in children. The mechanism of action of acetylcysteine in the
O. I. Simonova, K. A. Ikonnikova
doaj  

Precision‐Engineered Silver Single‐Atom Carbon Dot Nanozymes for Theranostic Management of Acute Kidney Injury

Advanced Science, EarlyView.
Mitochondria‐targeted silver single‐atom carbon dot (T‐AgSA‐CDs) nanozymes enable dual SOD/GPx‐like ROS scavenging, real‐time imaging, and therapeutic effects for acute kidney injury (AKI). Atomically dispersed Ag sites synergize with carbon dots to restore renal redox hemostasis, protect mitochondrial function, mitigate inflammation, facilitate post ...
Tianle Tang, Jun Zhang, Yan Wang, Guoping Chen, Kehui Yuan, Yuan He, Chenchen Li, Sumaira Hanif, Yang Yang, Yanli Wang, Pir Muhammad   +10 more
wiley   +1 more source