Results 1 to 10 of about 95,792 (372)

Posttranslational regulation of the GCN5 and PCAF acetyltransferases

PLoS Genetics, 2022
General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone and non-histone proteins using acetyl coenzyme A as a donor substrate.
Onyekachi E. Ononye, Michael Downey
doaj   +3 more sources

Lysine Acetyltransferases and Their Role in AR Signaling and Prostate Cancer

Frontiers in Endocrinology, 2022
The development and growth of a normal prostate gland, as well as its physiological functions, are regulated by the actions of androgens through androgen receptor (AR) signaling which drives multiple cellular processes including transcription, cellular ...
Bharti Jaiswal, Akanksha Agarwal, Ashish Gupta   +2 more
doaj   +2 more sources

The acetyltransferase CysE modulates virulence and drug resistance of Mycobacterium tuberculosis by interfering with oxidative stress responses [PDF]

Communications Biology
Acetyltransferases play a crucial role in biological processes by modifying a variety of substrates. However, their roles in the virulence of Mycobacterium tuberculosis (M. tb) are poorly understood.
Lan-Yue Zhang, Han Yin, Ying-Chao Wang, Mei-Yi Yan, Chun-Liang Wang, Xue-Tian Shang, Wei-Yi Liu, Zi-Hui Li, Hong-Yan Jia, Zong-De Zhang, Chuan-Zhi Zhu, Li-Ping Pan, Yi-Cheng Sun   +12 more
doaj   +2 more sources

Plant Cell Wall Polysaccharide O-Acetyltransferases [PDF]

Plants
Plant cell walls are largely composed of polysaccharide polymers, including cellulose, hemicelluloses (xyloglucan, xylan, mannan, and mixed-linkage β-1,3/1,4-glucan), and pectins.
Ruiqin Zhong, Dayong Zhou, Lirong Chen, John P. Rose, Bi-Cheng Wang, Zheng-Hua Ye   +5 more
doaj   +2 more sources

N<i>-</i>acetyltransferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in <i>Mycobacterium marinum</i>. [PDF]

Proc Natl Acad Sci U S A
Jones BS, Pareek V, Hu DD, Weaver SD, Syska C, Galfano G, Champion MM, Champion PA.   +7 more
europepmc   +2 more sources

Roles of histone acetylation sites in cardiac hypertrophy and heart failure

Frontiers in Cardiovascular Medicine, 2023
Heart failure results from various physiological and pathological stimuli that lead to cardiac hypertrophy. This pathological process is common in several cardiovascular diseases and ultimately leads to heart failure.
Masafumi Funamoto, Masaki Imanishi, Koichiro Tsuchiya, Yasumasa Ikeda   +3 more
doaj   +1 more source

FgHAT2 is involved in regulating vegetative growth, conidiation, DNA damage repair, DON production and virulence in Fusarium graminearum

Journal of Integrative Agriculture, 2020
Histone lysine acetylation is catalyzed by acetyltransferases (HATs), which is important in regulating gene expression and physiological function in eukaryotic cells. HATs can be classified into two main types: A- and B-type HATs.
Wu-yun LÜ, Nan YANG, Zhe XU, Han DAI, Shuai TANG, Zheng-yi WANG   +5 more
doaj   +1 more source

A polyamine acetyltransferase regulates the motility and biofilm formation of Acinetobacter baumannii

Nature Communications, 2023
Acinetobacter baumannii is a nosocomial pathogen highly resistant to environmental changes and antimicrobial treatments. Regulation of cellular motility and biofilm formation is important for its virulence, although it is poorly described at the ...
Julija Armalytė, Albinas Čepauskas, Gabija Šakalytė, Julius Martinkus, Jūratė Skerniškytė, Chloé Martens, Edita Sužiedėlienė, Abel Garcia-Pino, Dukas Jurėnas   +8 more
doaj   +1 more source

A synopsis of eukaryotic N^α-terminal acetyltransferases: nomenclature, subunits and substrates [PDF]

BMC Proceedings, 2009
We have introduced a consistent nomenclature for the various subunits of the NatA-NatE N-terminal acetyltransferases from yeast, humans and other eukaryotes.
Polevoda Bogdan, Arnesen Thomas, Sherman Fred   +2 more
doaj   +1 more source

Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family

Communications Biology, 2022
A comprehensive functional and structural study of the Antibiotic_NAT family of aminoglycoside acetyltransferases provides new insight into the molecular mechanisms underlying resistance to existing and emerging aminoglycoside antibiotics.
Peter J. Stogios, Emily Bordeleau, Zhiyu Xu, Tatiana Skarina, Elena Evdokimova, Sommer Chou, Luke Diorio-Toth, Alaric W. D’Souza, Sanket Patel, Gautam Dantas, Gerard D. Wright, Alexei Savchenko   +11 more
doaj   +1 more source