Results 1 to 10 of about 93,058 (385)
The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis [PDF]
Frontiers in Oncology, 2015 Histone or non-histone protein acetylation plays important roles in all kinds of cellular events, including the normal and abnormal development of blood cells, through changing the epigenetic status of chromatin and regulating non-histone protein’s ...
Xiao-jian Sun, Stephen D Nimer, Lan Wang
exaly +6 more sources
Posttranslational regulation of the GCN5 and PCAF acetyltransferases
PLoS Genetics, 2022 General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone and non-histone proteins using acetyl coenzyme A as a donor substrate.
Onyekachi E. Ononye, Michael Downey
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HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis
Frontiers in Plant Science, 2017 Arabidopsis has 12 histone acetyltransferases grouped in four families: the GNAT/HAG, the MYST/HAM, the p300/CBP/HAC and the TAFII250/HAF families. We previously showed that ham1 and ham2 mutants accumulated higher damaged DNA after UV-B exposure than WT
Sebastián Rius, Paula Casati
exaly +4 more sources
Lysine Acetyltransferases and Their Role in AR Signaling and Prostate Cancer
Frontiers in Endocrinology, 2022 The development and growth of a normal prostate gland, as well as its physiological functions, are regulated by the actions of androgens through androgen receptor (AR) signaling which drives multiple cellular processes including transcription, cellular ...
Bharti Jaiswal +2 more
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Plant Cell Wall Polysaccharide O-Acetyltransferases [PDF]
PlantsPlant cell walls are largely composed of polysaccharide polymers, including cellulose, hemicelluloses (xyloglucan, xylan, mannan, and mixed-linkage β-1,3/1,4-glucan), and pectins.
Ruiqin Zhong +5 more
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Exploring the role of N-acetyltransferases in diseases: a focus on N-acetyltransferase 9 in neurodegeneration [PDF]
Neural Regeneration ResearchAcetyltransferases, required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.
Prajakta Deshpande +2 more
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Targeting EP300 in diffuse large b-cell lymphoma: efficacy of A485 and synergistic effects with XPO1 inhibition [PDF]
BMC CancerBackground Diffuse large B-cell lymphoma (DLBCL) is an aggressive hematopoietic malignancy, necessitating the exploration of innovative therapeutic approaches. Targeting epigenetic mechanisms has emerged as a promising avenue for cancer treatment.
Yanan Jiang +8 more
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Roles of histone acetylation sites in cardiac hypertrophy and heart failure
Frontiers in Cardiovascular Medicine, 2023 Heart failure results from various physiological and pathological stimuli that lead to cardiac hypertrophy. This pathological process is common in several cardiovascular diseases and ultimately leads to heart failure.
Masafumi Funamoto +3 more
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Acetyltransferases and tumour suppression [PDF]
Breast Cancer Research, 2000 The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrating a role for p300 in human tumours was lacking until the recently publication by Gayther et al, which strongly supports a role for p300 as a ...
Karen H. Vousden, Andrew C. Phillips
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The BRCA2 is a histone acetyltransferase [PDF]
Oncogene, 1998 Patients carrying mutations in BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers. Two potential functions of BRCA2 were proposed which includes role in the regulation of transcription and also in DNA repair.
J.-P. Zou +3 more
openaire +2 more sources