Results 11 to 20 of about 95,792 (372)

MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain

Nature Communications, 2023
Human acetyltransferases MOZ and MORF mediate development programs and are dysregulated in diseases. Here the authors identified two winged helix (WH) domains in MORF/MOZ and characterized their DNA binding functions, including targeting of CpG by WH1.
Dustin C. Becht, Brianna J. Klein, Akinori Kanai, Suk Min Jang, Khan L. Cox, Bing-Rui Zhou, Sabrina K. Phanor, Yi Zhang, Ruo-Wen Chen, Christopher C. Ebmeier, Catherine Lachance, Maxime Galloy, Amelie Fradet-Turcotte, Martha L. Bulyk, Yawen Bai, Michael G. Poirier, Jacques Côté, Akihiko Yokoyama, Tatiana G. Kutateladze   +18 more
doaj   +2 more sources

Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases.

PLoS Computational Biology, 2020
The enzymes of the GCN5-related N-acetyltransferase (GNAT) superfamily count more than 870 000 members through all kingdoms of life and share the same structural fold.
Bojan Krtenic, Adrian Drazic, Thomas Arnesen, Nathalie Reuter   +3 more
doaj   +2 more sources

Mycobacterial Aminoglycoside Acetyltransferases: A Little of Drug Resistance, and a Lot of Other Roles

Frontiers in Microbiology, 2019
Aminoglycoside acetyltransferases are important determinants of resistance to aminoglycoside antibiotics in most bacterial genera. In mycobacteria, however, aminoglycoside acetyltransferases contribute only partially to aminoglycoside susceptibility ...
Fernando Sanz-García, Ernesto Anoz-Carbonell, Ernesto Anoz-Carbonell, Esther Pérez-Herrán, Carlos Martín, Carlos Martín, Ainhoa Lucía, Ainhoa Lucía, Liliana Rodrigues, Liliana Rodrigues, Liliana Rodrigues, José A. Aínsa, José A. Aínsa   +12 more
doaj   +2 more sources

The K46 and K5 capsular polysaccharides produced by Acinetobacter baumannii NIPH 329 and SDF have related structures and the side-chain non-ulosonic acids are 4-O-acetylated by phage-encoded O-acetyltransferases.

PLoS ONE, 2019
Acinetobacter baumannii isolate NIPH 329 carries a novel capsular polysaccharide (CPS) gene cluster, designated KL46, that is closely related to the KL5 locus in A.
Johanna J Kenyon, Nikolay P Arbatsky, Mikhail M Shneider, Anastasiya V Popova, Andrei S Dmitrenok, Anastasiya A Kasimova, Alexander S Shashkov, Ruth M Hall, Yuriy A Knirel   +8 more
doaj   +2 more sources

Identification of Novel Protein Lysine Acetyltransferases in Escherichia coli

mBio, 2018
Posttranslational modifications, such as Nε-lysine acetylation, regulate protein function. Nε-lysine acetylation can occur either nonenzymatically or enzymatically.
David G. Christensen, Jesse G. Meyer, Jackson T. Baumgartner, Alexandria K. D’Souza, William C. Nelson, Samuel H. Payne, Misty L. Kuhn, Birgit Schilling, Alan J. Wolfe   +8 more
doaj   +2 more sources

HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis

Frontiers in Plant Science, 2017
Arabidopsis has 12 histone acetyltransferases grouped in four families: the GNAT/HAG, the MYST/HAM, the p300/CBP/HAC and the TAFII250/HAF families. We previously showed that ham1 and ham2 mutants accumulated higher damaged DNA after UV-B exposure than WT
Julieta P. Fina, Fiorella Masotti, Sebastián P. Rius, Franco Crevacuore, Paula Casati   +4 more
doaj   +2 more sources

The role of histone acetyltransferases in normal and malignant hematopoiesis

Frontiers in Oncology, 2015
Histone or non-histone protein acetylation plays important roles in all kinds of cellular events, including the normal and abnormal development of blood cells, through changing the epigenetic status of chromatin and regulating non-histone protein’s ...
Xiao-Jian eSun, Na eMan, Yurong eTan, Stephen eNimer, Lan eWang   +4 more
doaj   +2 more sources

Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents

Theranostics, 2022
The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their sequence homology and functional overlap and co-operation, are emerging as critical drivers of oncogenesis in the past several years.
Qingjuan Chen, Binhui Yang, Xiao-Chun Liu, Xu Dong Zhang, Lirong Zhang, Tao Liu   +5 more
semanticscholar   +1 more source

Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents

Nature Communications, 2021
Intramolecular charge transfer (ICT) is a fundamental mechanism that enables the development of numerous fluorophores and probes for bioimaging and sensing.
Chenxu Yan, Zhiqian Guo, Weijie Chi, Wei Fu, Syed Ali Abbas Abedi, Xiaogang Liu, H. Tian, Weihong Zhu   +7 more
semanticscholar   +1 more source

Histone Acetyltransferases and Stem Cell Identity

Cancers, 2021
Simple Summary Gene regulation is the major mechanism that allows us to develop from a single cell to a fully formed adult body containing numerous organs and tissues, >200 cell types and a total of about 50 trillion cells. One of the ways our cells turn
Ruicen He, Arthur Dantas, K. Riabowol
semanticscholar   +1 more source