Results 181 to 190 of about 3,306 (206)

Human odontoblasts express transient receptor protein and acid‐sensing ion channel mechanosensor proteins

Microscopy Research and Technique, 2011
Diverse proteins of the denegerin/epithelial sodium channel (DEG/ENa+C) superfamily, in particular those belonging to the acid-sensing ion channel (ASIC) family, as well as some members of the transient receptor protein (TRP) channel, function as ...
TERESA Cobo, Pablo Perez-Pinera, Juan Cobo   +2 more
exaly   +2 more sources

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Acid-sensing ion channels (ASICs) 2 and 4.2 are expressed in the retina of the adult zebrafish

Cell and Tissue Research, 2015
Acid-sensing ion channels (ASICs) are H(+)-gated, voltage-insensitive cation channels involved in synaptic transmission, mechanosensation and nociception. Different ASICs have been detected in the retina of mammals but it is not known whether they are expressed in adult zebrafish, a commonly used animal model to study the retina in both normal and ...
Viña, E, PARISI, VALENTINA, Sánchez Ramos, C, Cabo, R, GUERRERA, Maria Cristina, Quirós, Lm, GERMANA', Antonino, Vega, Ja, García Suárez, O.   +8 more
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Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology

2008
Although brain pH is tightly controlled, it can be more dynamic than commonly appreciated. Physiological fluctuations in extracellular pH provide ample opportunity for protons to influence synaptic signaling. A number of synaptic proteins are modified by extracellular pH.
John A. Wemmie, Xiang-ming Zha, Michael J. Welsh   +2 more
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Acid Sensing Ion Channel 1a (ASIC1a) Mediates Activity-induced Pain by Modulation of Heteromeric ASIC Channel Kinetics

Neuroscience, 2018
Chronic muscle pain is acutely worsened by exercise. Acid sensing ion channels (ASIC) are heteromeric channels expressed in muscle sensory neurons that detect decreases in pH. We have previously shown ASIC3 is important in activity-induced hyperalgesia. However, ASICs form heteromers with ASIC1a being a key component in sensory neurons.
Nicholas S Gregory, Christopher J Benson, Kathleen A Sluka   +2 more
exaly   +3 more sources

Acid-sensing ion channels (ASICs) influence excitability of stellate neurons in the mouse cochlear nucleus

Journal of Comparative Physiology A, 2019
Acid-sensing ion channels (ASICs) are voltage-independent and proton-gated channels. In this study, we aimed to test the hypothesis whether ASICs might be involved in modifying the excitability of stellate cells in the cochlear nucleus (CN). We determined gene expressions of ASIC1, ASIC2 and ASIC3 in the CN of BALB/mice. ASIC currents in stellate cells
Ziya Cakir, Caner Yildirim, Ilay Buran, Ebru Etem Önalan, Ramazan Bal   +4 more
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Molecular cloning and characterization of human acid sensing ion channel (ASIC)2 gene promoter

Gene, 2003
Acid sensing ion channel (ASIC)2 belongs to the amiloride-sensitive Na(+)-channel/ degenerin family. Our previous studies suggested that differential regulation of ASIC2 expression occurs between high-grade glial-derived tumor cells and normal astrocytes. To investigate the mechanisms involved in the regulation of ASIC2 gene expression, the human ASIC2
Jiazeng, Xia, Zhen Hong, Zhou, James K, Bubien, Catherine M, Fuller, James M, Markert, Timothy B, Mapstone, G Yancey, Gillespie, Dale J, Benos   +7 more
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[Acid-Sensing Ion Channels (ASICs) in pain].

Biologie aujourd'hui, 2015
The discovery of new drug targets represents a real opportunity for developing fresh strategies against pain. Ion channels are interesting targets because they are directly involved in the detection and the transmission of noxious stimuli by sensory fibres of the peripheral nervous system and by neurons of the spinal cord.
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Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models

Psychopharmacology, 2008
Acid sensing ion channels (ASICs) are proton-gated ion channels located in the central and peripheral nervous systems. Of particular interest is ASIC1a, which is located in areas associated with fear and anxiety behaviors. Recent reports suggest a role for ASIC1a in preclinical models of fear conditioning and anxiety.The present experiments evaluated ...
Jason M, Dwyer, Stacey J Sukoff, Rizzo, Sarah J, Neal, Qian, Lin, Flora, Jow, Robert L, Arias, Sharon, Rosenzweig-Lipson, John, Dunlop, Chad E, Beyer   +8 more
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Neuroprotective effects of inhibitors of Acid-Sensing ion channels (ASICs) in optic nerve crush model in rodents

Current Eye Research, 2017
The purpose of the current study was to assess the potential involvement of acid-sensing ion channel 1 (ASIC1) in retinal ganglion cell (RGC) death and investigate the neuroprotective effects of inhibitors of ASICs in promoting RGC survival following optic nerve crush (ONC).ASIC1 protein was significantly increased in optic nerve extracts at day 7 ...
Dorota L. Stankowska, Brett H. Mueller, Hidehiro Oku, Tsunehiko Ikeda, Adnan Dibas   +4 more
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Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment

2009
Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in peripheral sensory neurons and in neurons of the central nervous system. Recent studies have demonstrated that activation of these channels plays an important role in a variety of physiological and pathological processes such as nociception, mechanosensation ...
openaire   +2 more sources