Results 171 to 180 of about 3,306 (206)

Acid‐sensing ion channel (ASIC) 1a undergoes a height transition in response to acidification

FEBS Letters, 2010
The acid‐sensing ion channel (ASIC) 1a is known to assemble as a homotrimer. Here, we used atomic force microscopy to image ASIC1a, integrated into lipid bilayers, at pH 7.0 and pH 6.0. The triangular appearance of the channel was clearly visible. A height distribution for the channels at pH 7.0 had two peaks, at 2 and 4 nm, likely representing the ...
Masatoshi Yokokawa, Robert M Henderson, Kunio Takeyasu   +2 more
exaly   +4 more sources

Interaction of Acid-sensing Ion Channel (ASIC) 1 with the Tarantula Toxin Psalmotoxin 1 is State Dependent [PDF]

Journal of General Physiology, 2006
Acid-sensing ion channels (ASICs) are Na+ channels gated by extracellular H+. Six ASIC subunits that are expressed in neurons have been characterized. The tarantula toxin psalmotoxin 1 has been reported to potently and specifically inhibit homomeric ASIC1a and has been useful to characterize ASICs in neurons.
Xuanmao Chen, Stefan Grunder
exaly   +6 more sources

Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms [PDF]

Neuropharmacology, 2017
Acid-sensing ion channels (ASICs) are proton-activated cation channels that are expressed in a variety of neuronal and non-neuronal tissues. As proton-gated channels, they have been implicated in many pathophysiological conditions where pH is perturbed ...
Ben Cristofori-Armstrong, Lachlan D Rash   +1 more
exaly   +2 more sources

The Acid-Activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory

Neuron, 2002
Many central neurons possess large acid-activated currents, yet their molecular identity is unknown. We found that eliminating the acid sensing ion channel (ASIC) abolished H+-gated currents in hippocampal neurons.
John A Wemmie, Candice C Askwith, Toshinori Hoshi   +2 more
exaly   +2 more sources

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Biophysical properties of acid-sensing ion channels (ASICs)

Neuropharmacology, 2015
Acid-sensing ion channels (ASICs) are ligand-gated ion channels that are exquisitely sensitive to extracellular protons and can sense transient as well as sustained acidification. In this review, we will discuss activation and desensitization of ASICs by protons.
Grunder S, Pusch M
openaire   +3 more sources

Acid-Sensing Ion Channels (ASICs): Pharmacology and implication in pain

Pharmacology & Therapeutics, 2010
Tissue acidosis is a common feature of many painful conditions. Protons are indeed among the first factors released by injured tissues, inducing a local pH fall that depolarizes peripheral free terminals of nociceptors and leads to pain. ASICs are excitatory cation channels directly gated by extracellular protons that are expressed in the nervous ...
Deval, Emmanuel, Gasull, Xavier, Noël, Jacques, Salinas, Miguel, Baron, Anne, Diochot, Sylvie, Lingueglia, Eric   +6 more
openaire   +4 more sources

Acid-sensing ion channels (ASICs) in the taste buds of adult zebrafish

Neuroscience Letters, 2013
In detecting chemical properties of food, different molecules and ion channels are involved including members of the acid-sensing ion channels (ASICs) family. Consistently ASICs are present in sensory cells of taste buds of mammals. In the present study the presence of ASICs (ASIC1, ASIC2, ASIC3 and ASIC4) was investigated in the taste buds of adult ...
Viña E, Parisi V, Cabo R, LAURA', Rosaria, López Velasco S, López Muñiz A, García Suárez O, GERMANA', Antonino, Vega J.A.   +8 more
openaire   +3 more sources

An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats

NeuroReport, 1998
The acid sensing ion channel (ASIC) identified in rat brain and spinal cord is potentially involved in the transmission of acid-induced nociception. We have developed polyclonal antisera against ASIC, and used them to screen rat brain and spinal cord using immunocytochemistry. ASIC-immunoreactivity (-ir) is present in but not limited to the superficial
Lucy Vulchanova, Xilma R Ortiz-Gonzalez, R Elde   +2 more
exaly   +3 more sources

Increased acid-sensing ion channel ASIC-3 in inflamed human intestine

European Journal of Gastroenterology & Hepatology, 2001
Acid-sensing ion channels (ASICs) are expressed by rat sensory neurons and may mediate pain associated with tissue acidosis after inflammation or injury. Our aim was to examine the molecular forms and localization of ASICs in human intestine and dorsal root ganglia using immunochemical techniques, and to measure the effects of inflammation and injury ...
Y, Yiangou, P, Facer, J A, Smith, L, Sangameswaran, R, Eglen, R, Birch, C, Knowles, N, Williams, P, Anand   +8 more
openaire   +2 more sources