Results 41 to 50 of about 3,011 (167)
Toxins, 2022 The nicotinic acetylcholine receptors (nAChRs) are prototypical ligand-gated ion channels, provide cholinergic signaling, and are modulated by various venom toxins and drugs in addition to neurotransmitters.
Rimma S. Kalina +15 more
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BMB Reports, 2013 Extracellular acidification occurs not only in pathological conditions such as inflammation and brain ischemia, but also in normal physiological conditions such as synaptic transmission. Acid-sensing ion channels (ASICs) can detect a broad range of physiological pH changes during pathological and synaptic cellular activities.
Kweon, Hae-Jin, Suh, Byung-Chang
openaire +5 more sources
Biomolecules, 2020 Machaerium hirtum (Vell.) Stellfeld (Fabaceae) known in Brazil as “jacaranda de espinho” or “espinheira santa nativa” is a medicinal plant commonly used in folk medicine to treat ulcers, cough and diarrhea.
Juliana Agostinho Lopes +10 more
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Topography and motion of acid-sensing ion channel intracellular domains
eLife, 2021 Acid-sensing ion channels (ASICs) are trimeric cation-selective channels activated by decreases in extracellular pH. The intracellular N and C terminal tails of ASIC1 influence channel gating, trafficking, and signaling in ischemic cell death.
Tyler Couch +5 more
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Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis
Journal of Biomedical Science, 2012 Background Recent data have suggested a relationship between acute arthritic pain and acid sensing ion channel 3 (ASIC3) on primary afferent fibers innervating joints.
Izumi Masashi +3 more
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Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution
eLife, 2023 Nervous systems are endowed with rapid chemosensation and intercellular signaling by ligand-gated ion channels (LGICs). While a complex, bilaterally symmetrical nervous system is a major innovation of bilaterian animals, the employment of specific LGICs ...
Josep Martí-Solans +4 more
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Endogenous Isoquinoline Alkaloids Agonists of Acid-Sensing Ion Channel Type 3
Frontiers in Molecular Neuroscience, 2017 Acid-sensing ion channels (ASICs) ASIC3 expressed mainly in peripheral sensory neurons play an important role in pain perception and inflammation development. In response to acidic stimuli, they can generate a unique biphasic current. At physiological pH
Dmitry I. Osmakov +5 more
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Frontiers in Cellular Neuroscience, 2021 Structures of the trimeric acid-sensing ion channel have been solved in the resting, toxin-bound open and desensitized states. Within the extracellular domain, there is little difference between the toxin-bound open state and the desensitized state.
Matthew L. Rook +3 more
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Molecular Pain, 2013 Background Extracellular acidosis is a prominent feature of multiple pathological conditions, correlating with pain sensation. Acid-sensing ion channels (ASICs), a family of proton-gated cation channels, are distributed throughout the central and ...
Tiandong Leng +3 more
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Frontiers in Molecular Neuroscience, 2019 Acid-sensing ion channels (ASICs) are neuronal Na+-permeable ion channels that are activated by extracellular acidification and are involved in fear sensing, learning, neurodegeneration after ischemia, and in pain sensation.
Anand Vaithia +4 more
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