Results 41 to 50 of about 3,306 (206)
, 2023 IntroductionIrritable bowel syndrome and bladder pain syndrome are both characterized by pain in response to organ distension. Epidemiologic studies showed that these two syndromes are often overlapped.
Moïse Coëffier (310979) +6 more
core +1 more source
Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2023.1
IUPHAR/BPS Guide to Pharmacology CITE, 2023 Acid-sensing ion channels (ASICs, nomenclature as agreed by NC-IUPHAR [48, 2, 3]) are members of a Na+ channel superfamily that includes the epithelial Na+ channel (ENaC), the FMRF-amide activated channel (FaNaC) of invertebrates, the degenerins (DEG) of Caenorhabitis elegans, channels in Drosophila melanogaster and 'orphan' channels that include ...
Lachlan D. Rash, Stephan Kellenberger
openaire +3 more sources
BMB Reports, 2013 Extracellular acidification occurs not only in pathological conditions such as inflammation and brain ischemia, but also in normal physiological conditions such as synaptic transmission. Acid-sensing ion channels (ASICs) can detect a broad range of physiological pH changes during pathological and synaptic cellular activities.
Kweon, Hae-Jin, Suh, Byung-Chang
openaire +5 more sources
Biomolecules, 2020 Machaerium hirtum (Vell.) Stellfeld (Fabaceae) known in Brazil as “jacaranda de espinho” or “espinheira santa nativa” is a medicinal plant commonly used in folk medicine to treat ulcers, cough and diarrhea.
Juliana Agostinho Lopes +10 more
doaj +1 more source
Topography and motion of acid-sensing ion channel intracellular domains
eLife, 2021 Acid-sensing ion channels (ASICs) are trimeric cation-selective channels activated by decreases in extracellular pH. The intracellular N and C terminal tails of ASIC1 influence channel gating, trafficking, and signaling in ischemic cell death.
Tyler Couch +5 more
doaj +1 more source
Acid-sensing ion channel 3: An analgesic target.
, 2020 Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin (ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes.
core +1 more source
Acid-sensing ion channel receptor-3 expression in nasal mucosa and its role in allergic rhinitis
, 2012 Allergie rhinitis affects a large proportion of the worldwide population, and its constituent symptoms include nasal blockage, rhinorrhoea and nasal pruritus.
S Guan Khoo (7961240)
core +1 more source
Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis
Journal of Biomedical Science, 2012 Background Recent data have suggested a relationship between acute arthritic pain and acid sensing ion channel 3 (ASIC3) on primary afferent fibers innervating joints.
Izumi Masashi +3 more
doaj +1 more source
Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution
eLife, 2023 Nervous systems are endowed with rapid chemosensation and intercellular signaling by ligand-gated ion channels (LGICs). While a complex, bilaterally symmetrical nervous system is a major innovation of bilaterian animals, the employment of specific LGICs ...
Josep Martí-Solans +4 more
doaj +1 more source
Endogenous Isoquinoline Alkaloids Agonists of Acid-Sensing Ion Channel Type 3
Frontiers in Molecular Neuroscience, 2017 Acid-sensing ion channels (ASICs) ASIC3 expressed mainly in peripheral sensory neurons play an important role in pain perception and inflammation development. In response to acidic stimuli, they can generate a unique biphasic current. At physiological pH
Dmitry I. Osmakov +5 more
doaj +1 more source