Results 31 to 40 of about 3,306 (206)
eLife, 2021 Acid-sensing ion channels (ASICs) are neuronal Na+ channels that are activated by a drop in pH. Their established physiological and pathological roles, involving fear behaviors, learning, pain sensation, and neurodegeneration after stroke, make them ...
Sabrina Vullo +4 more
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Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases [PDF]
Current Opinion in Pharmacology, 2008 A significant drop of tissue pH or acidosis is a common feature of acute neurological conditions such as ischemic stroke, brain trauma, and epileptic seizures. Acid-sensing ion channels, or ASICs, are proton-gated cation channels widely expressed in peripheral sensory neurons and in the neurons of the central nervous system.
Z.G. Xiong +4 more
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Reversible Slow Desensitization of the Acid-Sensing Ion Channel (ASIC) 1a [PDF]
, 2021 Abstract Among the proton-activated channels of the ASIC family, ASIC1a exhibits a specific tachyphylaxis phenomenon in the form of a progressive decrease in the response amplitude during a series of activations. This process is well known, but its mechanism is poorly understood.
Margarita S Komarova +3 more
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Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons [PDF]
Open Biology, 2012 A complex of stomatin-family proteins and acid-sensing (proton-gated) ion channel (ASIC) family members participate in sensory transduction in invertebrates and vertebrates.
Liudmila Lapatsina +7 more
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Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gating. [PDF]
The Journal of general physiology, 2004 Acid-sensing ion channels ASIC1a and ASIC1b are ligand-gated ion channels that are activated by H+ in the physiological range of pH. The apparent affinity for H+ of ASIC1a and 1b is modulated by extracellular Ca2+ through a competition between Ca2+ and H+.
Paukert M. +3 more
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Naked mole-rat cortical neurons are resistant to acid-induced cell death
Molecular Brain, 2018 Regulation of brain pH is a critical homeostatic process and changes in brain pH modulate various ion channels and receptors and thus neuronal excitability.
Zoé Husson, Ewan St. John Smith
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Proton Sensing on the Ocular Surface: Implications in Eye Pain
Frontiers in Pharmacology, 2021 Protons reaching the eyeball from exogenous acidic substances or released from damaged cells during inflammation, immune cells, after tissue injury or during chronic ophthalmic conditions, activate or modulate ion channels present in sensory nerve fibers
Núria Comes +5 more
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Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2021.3
IUPHAR/BPS Guide to Pharmacology CITE, 2021 Acid-sensing ion channels (ASICs, nomenclature as agreed by NC-IUPHAR [45, 2, 3]) are members of a Na+ channel superfamily that includes the epithelial Na+ channel (ENaC), the FMRF-amide activated channel (FaNaC) of invertebrates, the degenerins (DEG) of Caenorhabitis elegans, channels in Drosophila melanogaster and 'orphan' channels that include ...
Lachlan D. Rash, Stephan Kellenberger
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Acid Sensing Ion Channels (ASICs) in NS20Y cells – potential role in neuronal differentiation [PDF]
Molecular Brain, 2016 Cultured neuronal cell lines can express properties of mature neurons if properly differentiated. Although the precise mechanisms underlying neuronal differentiation are not fully understood, the expression and activation of ion channels, particularly those of Ca(2+)-permeable channels, have been suggested to play a role. In this study, we explored the
Zaven O’Bryant +5 more
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