Results 11 to 20 of about 3,011 (167)

The Isolated Thumb Domain of Acid-Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding Studies. [PDF]

Angew Chem Int Ed Engl
An independently folded thumb domain from acid‐sensing ion channels (ASICs) preserves ligand‐binding and proton‐sensing properties. NMR‐based interaction and pKa analyses uncover how endogenous and exogenous peptides modulate ASICs, providing a simplified model for rational drug discovery targeting proton‐gated ion channels.
Mishra BP, Cristofori-Armstrong B, Budusan E, Golder M, Butcher NJ, Liu J, Crawford T, Chin YK, Schmidt AP, Jia X, Smallwood TB, Clark RJ, Wurm JP, Rash LD, Mobli M.   +14 more
europepmc   +3 more sources

Calcium regulates acid-sensing ion channel 3 activation by competing with protons in the channel pore and at an allosteric binding site

Open Biology, 2022
The extracellular Ca2+ concentration changes locally under certain physiological and pathological conditions. Such variations affect the function of ion channels of the nervous system and consequently also neuronal signalling.
Sophie Roy, Niklaus Johner, Viktor Trendafilov, Ivan Gautschi, Olivier Bignucolo, Ophélie Molton, Simon Bernèche, Stephan Kellenberger   +7 more
doaj   +1 more source

Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention

Cell Death Discovery, 2023
Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues ...
Zhenyu Zhang, Minnan Chen, Wenjing Zhan, Yuechun Chen, Tongtong Wang, Zhonghua Chen, Yifei Fu, Gang Zhao, Dong Mao, Jingjing Ruan, Feng-Lai Yuan   +10 more
doaj   +1 more source

Retinoic Acid-Differentiated Neuroblastoma SH-SY5Y Is an Accessible In Vitro Model to Study Native Human Acid-Sensing Ion Channels 1a (ASIC1a)

Biology, 2022
Human neuroblastoma SH-SY5Y is a prominent neurobiological tool used for studying neuropathophysiological processes. We investigated acid-sensing (ASIC) and transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) ion channels present in ...
Aleksandr P. Kalinovskii, Dmitry I. Osmakov, Sergey G. Koshelev, Kseniya I. Lubova, Yuliya V. Korolkova, Sergey A. Kozlov, Yaroslav A. Andreev   +6 more
doaj   +1 more source

The role of acid sensing ion channels in the cardiovascular function

Frontiers in Physiology, 2023
Acid Sensing Ion Channels (ASIC) are proton sensors involved in several physiological and pathophysiological functions including synaptic plasticity, sensory systems and nociception.
Omar López-Ramírez, Antonia González-Garrido   +1 more
doaj   +1 more source

Proton and non-proton activation of ASIC channels. [PDF]

PLoS ONE, 2017
The Acid-Sensing Ion Channels (ASIC) exhibit a fast desensitizing current when activated by pH values below 7.0. By contrast, non-proton ligands are able to trigger sustained ASIC currents at physiological pHs. To analyze the functional basis of the ASIC
Ivan Gautschi, Miguel Xavier van Bemmelen, Laurent Schild   +2 more
doaj   +1 more source

Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate

eLife, 2021
Acid-sensing ion channels (ASICs) are neuronal Na+ channels that are activated by a drop in pH. Their established physiological and pathological roles, involving fear behaviors, learning, pain sensation, and neurodegeneration after stroke, make them ...
Sabrina Vullo, Nicolas Ambrosio, Jan P Kucera, Olivier Bignucolo, Stephan Kellenberger   +4 more
doaj   +1 more source

Molecular and Functional Characterization of Acid-sensing Ion Channel (ASIC) 1b [PDF]

Journal of Biological Chemistry, 2001
Acid-sensing ion channels (ASICs) are activated by extracellular protons and are involved in neurotransmission in the central nervous system, in pain perception, as well as in mechanotransduction. Six different ASIC subunits have been cloned to date, which are encoded by four genes (ASIC1-ASIC4).
E L, Bässler, T J, Ngo-Anh, H S, Geisler, J P, Ruppersberg, S, Gründer   +4 more
openaire   +2 more sources

Recent progress and debates in molecular physiology of Na+ uptake in teleosts

Frontiers in Marine Science, 2023
How teleosts take up Na+ from the surrounding freshwater (FW) as well as the underlying mechanisms associated with this process have received considerable attention over the past 85 years.
Shang-Wu Shih, Shang-Wu Shih, Jia-Jiun Yan, Ming-Yi Chou, Pung-Pung Hwang, Pung-Pung Hwang   +5 more
doaj   +1 more source

Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases [PDF]

Current Opinion in Pharmacology, 2008
A significant drop of tissue pH or acidosis is a common feature of acute neurological conditions such as ischemic stroke, brain trauma, and epileptic seizures. Acid-sensing ion channels, or ASICs, are proton-gated cation channels widely expressed in peripheral sensory neurons and in the neurons of the central nervous system.
Z.G. Xiong, PIGNATARO, GIUSEPPE, M. Li, S.Y. Chang, Simon R.P.   +4 more
openaire   +3 more sources