Results 11 to 20 of about 3,306 (206)

Involvement of acid sensing ion channel (ASIC)-3 in an acute urinary bladder-colon cross sensitization model in rodent [PDF]

Frontiers in Pain Research, 2023
IntroductionIrritable bowel syndrome and bladder pain syndrome are both characterized by pain in response to organ distension. Epidemiologic studies showed that these two syndromes are often overlapped.
Karim Atmani, Mathieu Meleine, Ludovic Langlois, Moïse Coëffier, Pablo Brumovsky, Anne-Marie Leroi, Anne-Marie Leroi, Guillaume Gourcerol, Guillaume Gourcerol   +8 more
doaj   +4 more sources

Physiologically relevant acid-sensing ion channel (ASIC) 2a/3 heteromers have a 1:2 stoichiometry [PDF]

Communications Biology, 2023
Acid-sensing ion channels (ASICs) sense extracellular protons and are involved in synaptic transmission and pain sensation. ASIC1a and ASIC3 are the ASIC subunits with the highest proton sensitivity.
Leon Fischer, Axel Schmidt, Anke Dopychai, Sylvia Joussen, Niko Joeres, Adrienne Oslender-Bujotzek, Günther Schmalzing, Stefan Gründer   +7 more
doaj   +2 more sources

Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention

Cell Death Discovery, 2023
Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues ...
Zhenyu Zhang, Minnan Chen, Wenjing Zhan, Yuechun Chen, Tongtong Wang, Zhonghua Chen, Yifei Fu, Gang Zhao, Dong Mao, Jingjing Ruan, Feng-Lai Yuan   +10 more
doaj   +2 more sources

The Isolated Thumb Domain of Acid-Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding Studies. [PDF]

Angew Chem Int Ed Engl
An independently folded thumb domain from acid‐sensing ion channels (ASICs) preserves ligand‐binding and proton‐sensing properties. NMR‐based interaction and pKa analyses uncover how endogenous and exogenous peptides modulate ASICs, providing a simplified model for rational drug discovery targeting proton‐gated ion channels.
Mishra BP, Cristofori-Armstrong B, Budusan E, Golder M, Butcher NJ, Liu J, Crawford T, Chin YK, Schmidt AP, Jia X, Smallwood TB, Clark RJ, Wurm JP, Rash LD, Mobli M.   +14 more
europepmc   +3 more sources

Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. [PDF]

J Biol Chem, 2012
Acid-sensing ion channels (ASICs) are neuronal Na(+)-selective channels that are transiently activated by extracellular acidification. ASICs are involved in fear and anxiety, learning, neurodegeneration after ischemic stroke, and pain sensation. The small molecule 2-guanidine-4-methylquinazoline (GMQ) was recently shown to open ASIC3 at physiological ...
Alijevic O, Kellenberger S.
europepmc   +7 more sources

Permeating protons contribute to tachyphylaxis of the acid‐sensing ion channel (ASIC) 1a [PDF]

The Journal of Physiology, 2007
The homomeric acid‐sensing ion channel 1a (ASIC1a) is a H+‐activated ion channel with important physiological functions and pathophysiological impact in the central nervous system. Here we show that homomeric ASIC1a is distinguished from other ASICs by a reduced response to successive acid stimulations.
Chen, Xuanmao, Grunder, Stefan
openaire   +4 more sources

Calcium regulates acid-sensing ion channel 3 activation by competing with protons in the channel pore and at an allosteric binding site [PDF]

Open Biology, 2022
The extracellular Ca2+ concentration changes locally under certain physiological and pathological conditions. Such variations affect the function of ion channels of the nervous system and consequently also neuronal signalling.
Sophie Roy, Niklaus Johner, Viktor Trendafilov, Ivan Gautschi, Olivier Bignucolo, Ophélie Molton, Simon Bernèche, Stephan Kellenberger   +7 more
doaj   +2 more sources

Restrictive expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum. [PDF]

PLoS ONE, 2014
Acid-sensing ion channels (Asic) are ligand-gated ion channels in the Degenerin/Epithelial Na+ channel (Deg/ENaC) family. Asic proteins are richly expressed in mammalian neurons. Mammals express five Asic genes: Asic1-5.
Nina Boiko, Volodymyr Kucher, Bin Wang, James D Stockand   +3 more
doaj   +2 more sources

Proton signaling links epithelial sensing to neural control of host defense in C. elegans [PDF]

Nature Communications
Effective host defense against pathogens requires coordinated behavioral and immune responses, yet the mechanisms that couple epithelial sensing to these systemic defenses remain poorly understood.
Ying Lei, Xu Zhan, Chao Chen, Yuxin Liu, Ying Wang, Ping Liu   +5 more
doaj   +2 more sources

Inhibition of ASIC1a Attenuates Neuronal Pyroptosis and Neuroinflammation Following Traumatic Brain Injury. [PDF]

CNS Neurosci Ther
This study identifies ASIC1a as a key modulator of neuroinflammation following traumatic brain injury. Pharmacological inhibition of ASIC1a mitigates neuronal pyroptosis and improves neurological outcomes, a protective effect closely associated with the downregulation of the NF‐κB/NLRP3 signaling axis.
Liang J, Chen P, Zhao Y, Lei P, Li Y, Zhang Y, Cai JH, Jiang YA, Zhang Y, Cheng S.   +9 more
europepmc   +2 more sources