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Acid-Sensing Ion Channel 2: Function and Modulation
Membranes, 2022 Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. They are members of the degenerin/epithelial sodium channel family.
Andy Sivils +3 more
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Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels [PDF]
eLife, 2015 Tarantula toxins that bind to voltage-sensing domains of voltage-activated ion channels are thought to partition into the membrane and bind to the channel within the bilayer.
Kanchan Gupta +9 more
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eLife, 2020 Acid-sensing ion channels (ASICs) are proton-gated members of the epithelial sodium channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout the central and peripheral nervous systems.
Nate Yoder, Eric Gouaux
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Frontiers in Molecular Neuroscience, 2022 Human acid-sensing ion channels (ASIC) are ligand-gated ionotropic receptors expressed widely in peripheral tissues as well as sensory and central neurons and implicated in detection of inflammation, tissue injury, and hypoxia-induced acidosis.
John Ridley +8 more
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Biomolecules, 2019 Acid-sensing ion channel (ASIC) channels belong to the family of ligand-gated ion channels known as acid-sensing (proton-gated) ion channels. Only a few activators of ASICs are known.
Dmitry I. Osmakov +4 more
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Physiological Reports, 2023 Peripheral artery diseases (PAD) increases muscle afferent nerve‐activated reflex sympathetic nervous and blood pressure responses during exercise (termed as exercise pressor reflex).
Qin Li, Lu Qin, Jianhua Li
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A COMPUTATIONAL STUDY ON Ca²⁺ MODULATION OF ASIC 1 PHARMACOLOGIC PROPERTIES
Studia Universitatis Babes-Bolyai Chemia, 2021 Acid-sensing ion channel (ASIC) is involved in important processes like synaptic plasticity and learning, fear and anxiety, pain sensation. Due to its role in neurodegeneration and neuroinflammation, the channel is a viable pharmacological target.
Raluca NICULAE +3 more
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Modulation of Ionotropic Glutamate Receptors and Acid-Sensing Ion Channels by Nitric Oxide
Frontiers in Physiology, 2012 Ionotropic glutamate receptors (iGluR) are ligand-gated ion channels and are densely expressed in broad areas of mammalian brains. Like iGluRs, acid-sensing ion channels (ASIC) are ligand (H+)-gated channels and are enriched in brain cells and ...
John Q Wang +7 more
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Frontiers in Physiology, 2021 Acid-Sensing Ion Channels (ASICs) are proton-gated sodium-selective cation channels that have emerged as metabolic and pain sensors in peripheral sensory neurons and contribute to neurotransmission in the CNS.
Daniel S. Matasic +18 more
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Toxins, 2022 The nicotinic acetylcholine receptors (nAChRs) are prototypical ligand-gated ion channels, provide cholinergic signaling, and are modulated by various venom toxins and drugs in addition to neurotransmitters.
Rimma S. Kalina +15 more
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