Involvement of acid sensing ion channel (ASIC)-3 in an acute urinary bladder-colon cross sensitization model in rodent [PDF]
Frontiers in Pain Research, 2023 IntroductionIrritable bowel syndrome and bladder pain syndrome are both characterized by pain in response to organ distension. Epidemiologic studies showed that these two syndromes are often overlapped.
Karim Atmani +8 more
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Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. [PDF]
J Biol Chem, 2012 Acid-sensing ion channels (ASICs) are neuronal Na(+)-selective channels that are transiently activated by extracellular acidification. ASICs are involved in fear and anxiety, learning, neurodegeneration after ischemic stroke, and pain sensation. The small molecule 2-guanidine-4-methylquinazoline (GMQ) was recently shown to open ASIC3 at physiological ...
Alijevic O, Kellenberger S.
europepmc +7 more sources
Physiologically relevant acid-sensing ion channel (ASIC) 2a/3 heteromers have a 1:2 stoichiometry [PDF]
Communications Biology, 2023 Acid-sensing ion channels (ASICs) sense extracellular protons and are involved in synaptic transmission and pain sensation. ASIC1a and ASIC3 are the ASIC subunits with the highest proton sensitivity.
Leon Fischer +7 more
doaj +2 more sources
Modulation of Slow Desensitization (Tachyphylaxis) of Acid-Sensing Ion Channel (ASIC)1a. [PDF]
Cell Mol Neurobiol, 2023 Among the proton-activated channels of the ASIC family, ASIC1a exhibits a specific tachyphylaxis phenomenon in the form of a progressive decrease in the response amplitude during a series of activations. This process is well known, but its mechanism is poorly understood. Here, we demonstrated a partial reversibility of this effect using long-term whole-
Komarova MS +3 more
europepmc +3 more sources
Proton signaling links epithelial sensing to neural control of host defense in C. elegans [PDF]
Nature CommunicationsEffective host defense against pathogens requires coordinated behavioral and immune responses, yet the mechanisms that couple epithelial sensing to these systemic defenses remain poorly understood.
Ying Lei +5 more
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Restrictive expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum. [PDF]
PLoS ONE, 2014 Acid-sensing ion channels (Asic) are ligand-gated ion channels in the Degenerin/Epithelial Na+ channel (Deg/ENaC) family. Asic proteins are richly expressed in mammalian neurons. Mammals express five Asic genes: Asic1-5.
Nina Boiko +3 more
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Acid‐sensing ion channel (ASIC) 1a undergoes a height transition in response to acidification
FEBS Letters, 2010 The acid‐sensing ion channel (ASIC) 1a is known to assemble as a homotrimer. Here, we used atomic force microscopy to image ASIC1a, integrated into lipid bilayers, at pH 7.0 and pH 6.0. The triangular appearance of the channel was clearly visible. A height distribution for the channels at pH 7.0 had two peaks, at 2 and 4 nm, likely representing the ...
Yokokawa, Masatoshi +4 more
exaly +3 more sources
Interaction of Acid-sensing Ion Channel (ASIC) 1 with the Tarantula Toxin Psalmotoxin 1 is State Dependent [PDF]
Journal of General Physiology, 2006 Acid-sensing ion channels (ASICs) are Na+ channels gated by extracellular H+. Six ASIC subunits that are expressed in neurons have been characterized. The tarantula toxin psalmotoxin 1 has been reported to potently and specifically inhibit homomeric ASIC1a and has been useful to characterize ASICs in neurons.
Xuanmao Chen, Stefan Grunder
exaly +4 more sources
Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms [PDF]
Neuropharmacology, 2017 Acid-sensing ion channels (ASICs) are proton-activated cation channels that are expressed in a variety of neuronal and non-neuronal tissues. As proton-gated channels, they have been implicated in many pathophysiological conditions where pH is perturbed.
Ben Cristofori-Armstrong +1 more
exaly +6 more sources
The relationship between acid-sensing ion channel, ASIC2, and oncogenic β-catenin signaling in ovarian cancer [PDF]
Scientific ReportsInflammation associated with incessant ovulation plays a key role in epithelial ovarian cancer (EOC) pathogenesis. Ion channels, such as acid-sensing ion channel-2 or ASIC2 are known to be upregulated in inflammatory conditions and may play a role in ...
Tanvi Joshi +6 more
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