Results 21 to 30 of about 3,306 (206)

Modulation of Slow Desensitization (Tachyphylaxis) of Acid-Sensing Ion Channel (ASIC)1a. [PDF]

Cell Mol Neurobiol, 2023
Among the proton-activated channels of the ASIC family, ASIC1a exhibits a specific tachyphylaxis phenomenon in the form of a progressive decrease in the response amplitude during a series of activations. This process is well known, but its mechanism is poorly understood. Here, we demonstrated a partial reversibility of this effect using long-term whole-
Komarova MS, Bukharev AR, Potapieva NN, Tikhonov DB.   +3 more
europepmc   +3 more sources

Molecular basis of inhibition of acid sensing ion channel 1A by diminazene. [PDF]

PLoS ONE, 2018
Acid-sensing ion channels (ASICs) are trimeric proton-gated cation permeable ion channels expressed primarily in neurons. Here we employed site-directed mutagenesis and electrophysiology to investigate the mechanism of inhibition of ASIC1a by diminazene.
Aram J Krauson, James G Rooney, Marcelo D Carattino   +2 more
doaj   +2 more sources

pH-Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal ...
Schwab A, Rugi M, Swietach P, Błaszczak W, Novak I, Deshar G, Pedersen SF, Ialchina R, Sandelin A, Yao J, Reshkin SJ, Cardone RA, Carvalho TMA, Arcangeli A, Bouazzi R, D'Alessandro FN, Prevarskaya N, Audero MM, Ouadid-Ahidouch H, Schnipper J, Pardo LA, Shi X, Alves F, Mitręga J, Trauzold A, Hagelund SE, Panyi G, Cozzolino M, Löwik CMWG, Mezzanotte L, McMorrow R, Pahl A, Hechler T, Papacharisi E, Pla AF, Szabo I, Hofschröer V, Pethő Z.   +37 more
europepmc   +2 more sources

The relationship between acid-sensing ion channel, ASIC2, and oncogenic β-catenin signaling in ovarian cancer [PDF]

Scientific Reports
Inflammation associated with incessant ovulation plays a key role in epithelial ovarian cancer (EOC) pathogenesis. Ion channels, such as acid-sensing ion channel-2 or ASIC2 are known to be upregulated in inflammatory conditions and may play a role in ...
Tanvi Joshi, Sagar Chokshi, Annelise Wilhite, Mary Howard Singleton, Elizabeth Catranis, Jennifer Scalici, Kevin J. Lee   +6 more
doaj   +2 more sources

Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.

International journal of physiology, pathophysiology and pharmacology, 2010
Acid-sensing ion channels (ASICs) are H(+)-gated Na(+) channels, which are present in most, if not all, neurons. The typical ASIC current is transient and is elicited by a rapid drop in the extracellular pH. In the human genome, four genes for ASICs are present: asic1 - 4.
Grunder, Stefan, Chen, Xuanmao
openaire   +3 more sources

Retinoic Acid-Differentiated Neuroblastoma SH-SY5Y Is an Accessible In Vitro Model to Study Native Human Acid-Sensing Ion Channels 1a (ASIC1a)

Biology, 2022
Human neuroblastoma SH-SY5Y is a prominent neurobiological tool used for studying neuropathophysiological processes. We investigated acid-sensing (ASIC) and transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) ion channels present in ...
Aleksandr P. Kalinovskii, Dmitry I. Osmakov, Sergey G. Koshelev, Kseniya I. Lubova, Yuliya V. Korolkova, Sergey A. Kozlov, Yaroslav A. Andreev   +6 more
doaj   +1 more source

The role of acid sensing ion channels in the cardiovascular function

Frontiers in Physiology, 2023
Acid Sensing Ion Channels (ASIC) are proton sensors involved in several physiological and pathophysiological functions including synaptic plasticity, sensory systems and nociception.
Omar López-Ramírez, Antonia González-Garrido   +1 more
doaj   +1 more source

Proton and non-proton activation of ASIC channels. [PDF]

PLoS ONE, 2017
The Acid-Sensing Ion Channels (ASIC) exhibit a fast desensitizing current when activated by pH values below 7.0. By contrast, non-proton ligands are able to trigger sustained ASIC currents at physiological pHs. To analyze the functional basis of the ASIC
Ivan Gautschi, Miguel Xavier van Bemmelen, Laurent Schild   +2 more
doaj   +1 more source

Recent progress and debates in molecular physiology of Na+ uptake in teleosts

Frontiers in Marine Science, 2023
How teleosts take up Na+ from the surrounding freshwater (FW) as well as the underlying mechanisms associated with this process have received considerable attention over the past 85 years.
Shang-Wu Shih, Shang-Wu Shih, Jia-Jiun Yan, Ming-Yi Chou, Pung-Pung Hwang, Pung-Pung Hwang   +5 more
doaj   +1 more source

Molecular and Functional Characterization of Acid-sensing Ion Channel (ASIC) 1b [PDF]

Journal of Biological Chemistry, 2001
Acid-sensing ion channels (ASICs) are activated by extracellular protons and are involved in neurotransmission in the central nervous system, in pain perception, as well as in mechanotransduction. Six different ASIC subunits have been cloned to date, which are encoded by four genes (ASIC1-ASIC4).
E L, Bässler, T J, Ngo-Anh, H S, Geisler, J P, Ruppersberg, S, Gründer   +4 more
openaire   +2 more sources