Results 21 to 30 of about 3,011 (167)
Reversible Slow Desensitization of the Acid-Sensing Ion Channel (ASIC) 1a [PDF]
, 2021 Abstract Among the proton-activated channels of the ASIC family, ASIC1a exhibits a specific tachyphylaxis phenomenon in the form of a progressive decrease in the response amplitude during a series of activations. This process is well known, but its mechanism is poorly understood.
Margarita S Komarova +3 more
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Permeating protons contribute to tachyphylaxis of the acid‐sensing ion channel (ASIC) 1a [PDF]
The Journal of Physiology, 2007 The homomeric acid‐sensing ion channel 1a (ASIC1a) is a H+‐activated ion channel with important physiological functions and pathophysiological impact in the central nervous system. Here we show that homomeric ASIC1a is distinguished from other ASICs by a reduced response to successive acid stimulations.
Chen, Xuanmao, Grunder, Stefan
openaire +3 more sources
Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons [PDF]
Open Biology, 2012 A complex of stomatin-family proteins and acid-sensing (proton-gated) ion channel (ASIC) family members participate in sensory transduction in invertebrates and vertebrates.
Liudmila Lapatsina +7 more
doaj +1 more source
Inhibition of ASIC1a Attenuates Neuronal Pyroptosis and Neuroinflammation Following Traumatic Brain Injury. [PDF]
CNS Neurosci TherThis study identifies ASIC1a as a key modulator of neuroinflammation following traumatic brain injury. Pharmacological inhibition of ASIC1a mitigates neuronal pyroptosis and improves neurological outcomes, a protective effect closely associated with the downregulation of the NF‐κB/NLRP3 signaling axis.
Liang J +9 more
europepmc +2 more sources
Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gating. [PDF]
The Journal of general physiology, 2004 Acid-sensing ion channels ASIC1a and ASIC1b are ligand-gated ion channels that are activated by H+ in the physiological range of pH. The apparent affinity for H+ of ASIC1a and 1b is modulated by extracellular Ca2+ through a competition between Ca2+ and H+.
Paukert M. +3 more
openaire +3 more sources
Naked mole-rat cortical neurons are resistant to acid-induced cell death
Molecular Brain, 2018 Regulation of brain pH is a critical homeostatic process and changes in brain pH modulate various ion channels and receptors and thus neuronal excitability.
Zoé Husson, Ewan St. John Smith
doaj +1 more source
Proton Sensing on the Ocular Surface: Implications in Eye Pain
Frontiers in Pharmacology, 2021 Protons reaching the eyeball from exogenous acidic substances or released from damaged cells during inflammation, immune cells, after tissue injury or during chronic ophthalmic conditions, activate or modulate ion channels present in sensory nerve fibers
Núria Comes +5 more
doaj +1 more source
Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels
eLife, 2015 Tarantula toxins that bind to voltage-sensing domains of voltage-activated ion channels are thought to partition into the membrane and bind to the channel within the bilayer.
Kanchan Gupta +9 more
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Frontiers in Molecular Neuroscience, 2022 Human acid-sensing ion channels (ASIC) are ligand-gated ionotropic receptors expressed widely in peripheral tissues as well as sensory and central neurons and implicated in detection of inflammation, tissue injury, and hypoxia-induced acidosis.
John Ridley +8 more
doaj +1 more source