Results 61 to 70 of about 3,306 (206)
Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. [PDF]
PLoS ONE, 2011 Together, acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) constitute the majority of voltage-independent sodium channels in mammals. ENaC is regulated by a chloride channel, the cystic fibrosis transmembrane conductance regulator (
Xuanmao Chen +3 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Previously, we have characterized the capsaicin-insensitive low pH-sensitive (caps−lpH+) subtype of small-sized nociceptive dorsal root ganglion (DRG) neurons that express acid-sensing ion channels, T-type Ca2+ channels, and have isolectin B4-negative ...
Dmytro E. Duzhyy +5 more
doaj +1 more source
Hypoxia‐induced vulnerability of the somatosensory nervous system
The Journal of Physiology, EarlyView.Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley +1 more source
Developmental Neurobiology, Volume 86, Issue 3, July 2026.ABSTRACT Lead is a toxic heavy metal with significant health risks, as maternal lead exposure during pregnancy disrupts fetal neural development through placental transfer, leading to persistent neurological, developmental, and long‐term health consequences in the progeny.
P. Harshitha +3 more
wiley +1 more source
산-감지 이온채널 (acid-sensing ion channel, ASIC) 의 세포막 운송 및 지질에 의한 활성 조절 메커니즘
, 2017 Acid-sensing ion channels (ASICs) are proton-activated cation channels that play important roles as typical proton sensors in the nervous system. Protons are released in pain-generating pathophysiological conditions such as inflammation, ischemic stroke,
Kweon, Hae Jin
core +1 more source
Molecular Brain, 2010 Background Acid-sensing ion channel 1a (ASIC1a) is the major ASIC subunit determining acid-activated currents in brain neurons. Recent studies show that ASIC1a play critical roles in acid-induced cell toxicity. While these studies raise the importance of
Jin Wenying +4 more
doaj +1 more source
Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy
MedComm, Volume 7, Issue 7, July 2026.Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu +5 more
wiley +1 more source
Upregulation of acid sensing ion channel 1a (ASIC1a) by hydrogen peroxide through the JNK pathway
, 2021 Oxidative stress is intimately tied to neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis, and acute injuries, such as ischemic stroke and traumatic brain injury.
Bao-ming Wu +11 more
core +1 more source
Advanced Materials Technologies, Volume 11, Issue 11, 5 June 2026.This work establishes a framework for high‐resolution printed interconnects by coupling e‐jet printing control, multilayer deposition, and sintering optimization. Ink properties and printing speed influence particle stacking, while different sintering atmospheres drive distinct microstructural evolution.
Kaifan Yue +6 more
wiley +1 more source
Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik +4 more
wiley +1 more source