Results 81 to 90 of about 3,011 (167)
Metabolomics study of APETx2 post-conditioning on myocardial ischemia-reperfusion injury
Frontiers in PharmacologyBackgroundAcid-sensing ion channels are activated during myocardial ischemia and are implicated in the mechanism of myocardial ischemia-reperfusion injury (MIRI).
Jing Li +10 more
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Acid-sensing ion channels: trafficking and synaptic function
Molecular Brain, 2013 Extracellular acidification occurs in the brain with elevated neural activity, increased metabolism, and neuronal injury. This reduction in pH can have profound effects on brain function because pH regulates essentially every single biochemical reaction.
Zha Xiang-ming
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Journal of Experimental & Clinical Cancer Research, 2017 Background The tumor acidic microenvironment, a common biochemical event in solid tumors, offers evolutional advantage for tumors cells and even enhances their aggressive phenotype.
Zhi-hang Zhou +9 more
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Multiple Modulation of Acid-Sensing Ion Channel 1a by the Alkaloid Daurisoline
Biomolecules, 2019 Acid-sensing ion channels (ASICs) are proton-gated sodium-selective channels that are expressed in the peripheral and central nervous systems. ASIC1a is one of the most intensively studied isoforms due to its importance and wide representation in ...
Dmitry I. Osmakov +6 more
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Stoichiometry of Acid-Sensing Ion Channel (ASIC) Pharmacology
Biophysical Journal, 2020 Matthew L. Rook, David M. MacLean
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International Journal of Clinical & Medical Allergy, 2016 Objective: Acid-sensing ion channels (ASICs) are cationic channels that are activated by extracellular acidification. ASICs are widely expressed in the peripheral and central nervous systems and participate in many important physiological and pathological processes, such as synaptic plasticity, cerebral ischemia, and pain.
Li-ping Yuan +4 more
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Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2025.4
IUPHAR/BPS Guide to Pharmacology CITEAcid-sensing ion channels (ASICs, nomenclature as agreed by NC-IUPHAR [52, 2, 3]) are members of a Na+ channel superfamily that includes the epithelial Na+ channel (ENaC), the FMRF-amide activated channel (FaNaC) of invertebrates, the degenerins (DEG) of Caenorhabditis elegans, channels in Drosophila melanogaster and the mammalian bile acid-activated ...
Stephan Kellenberger, Lachlan D. Rash
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ASIC currents in cultured primate retinal amacrine/ganglion cells
Physiological ReportsAcid‐sensing ion channels (ASICs) are proton‐gated cation channels belonging to the epithelial Na + channel/degenerin superfamily. In the CNS, ASICs are involved in synaptic plasticity, learning/memory, and acidosis‐mediated injury.
Talib Saafir +4 more
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Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.
International journal of physiology, pathophysiology and pharmacology, 2010 Acid-sensing ion channels (ASICs) are H(+)-gated Na(+) channels, which are present in most, if not all, neurons. The typical ASIC current is transient and is elicited by a rapid drop in the extracellular pH. In the human genome, four genes for ASICs are present: asic1 - 4.
Grunder, Stefan, Chen, Xuanmao
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Experimental Biology and MedicineEpilepsy affects more than 70 million people worldwide. A seizure focus that develops in different cortical brain regions can present as either focal or generalized seizures.
Volodymyr I. Pidoplichko +3 more
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