Results 81 to 90 of about 3,306 (206)

Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge, Chengsheng Ding, Xiao Yang, Si Gao, Changjie Yang, Yuchen Hou, Hongye Wang, Linke Bian, Hao Zhong, Yifan Qu, Luyang Zhang, Junjun Ma, Zhengwei Cai, Wenguo Cui, Minhua Zheng   +14 more
wiley   +1 more source

Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers

, 2017
Acid-sensing ion channels (ASICs) form both homotrimeric and heterotrimeric ion channels that are activated by extracellular protons and are involved in a wide range of physiological and pathophysiological processes, including pain and anxiety.
Laura-Nadine Schuhmacher, Gerard Callejo, Shyam Srivats, Ewan St. John Smith   +3 more
core   +1 more source

Epilepsy: Molecular Pathogenesis and Emerging Therapies

MedComm, Volume 7, Issue 4, April 2026.
Progress has been made in the molecular pathogenesis of epilepsy, revealing multiple therapeutic targets. Recent advances in pharmacology, materials science, and surgical technique, coupled with progress in targeted therapy and disruptive epilepsy network technology, have led to the emergence of innovative strategies for epilepsy treatment.
Wanbin Huang, Jiabin Zong, Yu Zhang, Ming Li, Songqing Pan, Zheman Xiao   +5 more
wiley   +1 more source

Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior

, 2006
The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Foulkes, T, Baker, MD, Matthews, EA, Gerke, V, Lane, T, Wood, JN, Okuse, K, Nassar, MA, Dickenson, AH   +8 more
core  

Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3

, 2018
Acid-sensing ion channels (ASICs) evolved to sense changes in extracellular acidity with the divalent cation calcium (Ca2+) as an allosteric modulator and channel blocker.
Zhicheng Zuo, Huang, Renqi, Zhenglan Chen, Amruta S. Agharkar, Liu, Jin, Snell, Heather D., Rachel N. Smith, Jin Liu, Chen, Zhenglan, Heather D. Snell, Smith, Rachel N., Zuo, Zhicheng, Eric B. Gonzales, Agharkar, Amruta S., Gonzales, Eric B., Renqi Huang   +15 more
core   +1 more source

Wireless Power Transfer Modalities for Implantable Bioelectronics: Electromagnetic, Acoustic, and Magneto‐Dynamic Perspectives

Advanced Materials Technologies, Volume 11, Issue 5, 6 March 2026.
This review traces the evolution of wireless power transfer (WPT) for implantable medical devices, spanning electromagnetic, magnetoelectric, acoustic, and magneto‐dynamic systems. Quantitative comparisons of power, distance, and device scale highlight trade‐offs across modalities, while emerging hybrid mechanisms reveal strategies to overcome ...
Junyeop Kim, Yoonseok Park
wiley   +1 more source

A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel

, 2010
SummaryAcid-sensing ion channels (ASICs) have long been considered as extracellular proton (H+)-gated cation channels, and peripheral ASIC3 channels seem to be a natural sensor of acidic pain.
Hong Liu, Ye Yu, Li, Wei-Guang, Cao, Hui, Tian-Le Xu, Xu, Tian-Le, Liu, Hong, Chen, Zhi, Feng, En-Guang, Zhi Chen, Wei-Guang Li, Hui Cao, En-Guang Feng, Yu, Ye, Hualiang Jiang, Yu, Fang, Jiang, Hualiang, Fang Yu   +17 more
core   +1 more source

Non‐Invasive, High‐Resolution (1H2O) Metabolic Activity Diffusion Imaging [MADI] of Rat Glioma

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
We employed Metabolic Activity Diffusion Imaging [MADI] and 18FDG‐PET in rats with syngeneic RG2 glioblastoma brain tumors. MADI quantifies kio (the cellular H2O efflux rate constant), cell volume (V), and cell density (ρ), without the use of contrast agents. The kioV product quantifies the rate of water efflux per cell.
Joshua W. Schlegel, Samantha M. Holland, Felice D. Kelly, Eric M. Baker, Jared Stoller, William Packwood, Xin Li, Ramon F. Barajas Jr., Charles S. Springer Jr., Martin M. Pike   +9 more
wiley   +1 more source

Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen

, 2017
A growing body of evidence links certain aspects of nonsteroidal anti-inflammatory drug (NSAID) pharmacology with acid-sensing ion channels (ASICs), a small family of excitatory neurotransmitter receptors implicated in pain and neuroinflammation.
Camilla Lund, Timothy Lynagh, José Luis Romero-Rojo, Stephan A. Pless, Lund, Camilla, Lynagh, Timothy, Pless, Stephan A, Romero-Rojo, José Luis   +7 more
core   +1 more source

APETx-Like Peptides from the Sea Anemone Heteractis crispa, Diverse in Their Effect on ASIC1a and ASIC3 Ion Channels

Toxins, 2020
Currently, five peptide modulators of acid-sensing ion channels (ASICs) attributed to structural class 1b of sea anemone toxins have been described. The APETx2 toxin is the first and most potent ASIC3 inhibitor, so its homologs from sea anemones are ...
Rimma S. Kalina, Sergey G. Koshelev, Elena A. Zelepuga, Natalia Y. Kim, Sergey A. Kozlov, Emma P. Kozlovskaya, Margarita M. Monastyrnaya, Irina N. Gladkikh   +7 more
doaj   +1 more source