Results 91 to 100 of about 3,011 (167)

Acid-sensing ion channel 2 (asic 2) and trkb interrelationships within the intervertebral disc.

International journal of clinical and experimental pathology, 2015
The cells of the intervertebral disc (IVD) have an unusual acidic and hyperosmotic microenvironment. They express acid-sensing ion channels (ASICs), gated by extracellular protons and mechanical forces, as well as neurotrophins and their signalling receptors. In the nervous tissues some neurotrophins regulate the expression of ASICs.
Cuesta, Antonio, Viña Fernández, Eliseo, Cabo Pérez, Roberto, Vázquez, Gorka, Cobo, Ramón, García Suárez, Olivia, García Cosamalón, José, Vega Álvarez, José Antonio   +7 more
openaire   +2 more sources

Blocking acid-sensing ion channel 1a attenuates bilirubin-induced ototoxicity in cochlear organotypic culture

Fundamental Research
Neonatal hyperbilirubinemia leads to neural dysfunction, including sensorineural hearing loss. Our previous studies demonstrated that elevated bilirubin induced apoptotic pathway activation and led to cell malformation in spiral ganglion neurons of ...
Yazhi Xing, Jia Jia, Ling Zhang, Fei Sun, Zhengnong Chen, Dalian Ding, Di Qian, Jianning Zhang, Haibo Ye, Haibo Shi, Shankai Yin   +10 more
doaj   +1 more source

Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression. [PDF]

Sci Rep, 2015
Schwartz V, Friedrich K, Polleichtner G, Gründer S.   +3 more
europepmc   +1 more source

Acid-sensing (proton-gated) ion channels (ASICs)

British Journal of Pharmacology, 2009
openaire   +2 more sources

Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry. [PDF]

Proc Natl Acad Sci U S A, 2014
Bartoi T, Augustinowski K, Polleichtner G, Gründer S, Ulbrich MH.   +4 more
europepmc   +1 more source

Acid-sensing ion channel 2a assembles with epithelial Na⁺ channel β and γ subunits to form mechanosensitive ion channels. [PDF]

J Biol Chem
Shi S, Whelan SCM, Szekely KG, Kashlan OB, Drummond H, Kleyman TR.   +5 more
europepmc   +1 more source

ROLES OF ACID-SENSING ION CHANNELS (ASICS) IN PERIPHERAL NEUROPEPTIDE SECRETION AND PAIN

, 2012
Acid-sensing ion channels (ASICs) are non-voltage-gated sodium channels activated by an extracellular acidification. They are widely expressed in neurons of the central and peripheral nervous system. ASICs have a role in learning, the expression of fear, in neuronal death after cerebral ischemia, and in pain sensation.
openaire   +1 more source

Acid-sensing ion channels and their role in controlling pain in the post-operative stage. [PDF]

Int J Physiol Pathophysiol Pharmacol
Warikoo G, Sun A, Chu XP.
europepmc   +1 more source

Zinc Permeation Through Acid-Sensing Ion Channels. [PDF]

Cells
Chu XP, Inoue K, Xiong ZG.
europepmc   +1 more source

[Corrigendum] Inhibition of acid‑sensing ion channel 1a attenuates acid‑induced activation of autophagy via a calcium signaling pathway in articular chondrocytes. [PDF]

Int J Mol Med
Gao WF, Xu YY, Ge JF, Chen FH.
europepmc   +1 more source