Results 91 to 100 of about 3,306 (206)

Potential Cation and H+ Binding Sites in Acid Sensing Ion Channel-1

, 2008
Acid sensing ion channels (ASICs) are cation-selective membrane channels activated by H+ binding upon decrease in extracellular pH. It is known that Ca2+ plays an important modulatory role in ASIC gating, competing with the ligand (H+) for its binding ...
Shaikh, Saher Afshan, Tajkhorshid, Emad
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Bile acids potentiate proton-activated currents in Xenopus laevis oocytes expressing human acid-sensing ion channel (ASIC1a)

, 2017
Acid‐sensing ion channels (ASICs) are nonvoltage‐gated sodium channels transiently activated by extracellular protons and belong to the epithelial sodium channel (ENaC)/Degenerin (DEG) family of ion channels.
Ilyaskin, Alexandr V., Christoph Korbmacher, Haerteis, Silke, Korbmacher, Christoph, Diakov, Alexei, Alexei Diakov, Silke Haerteis, Alexandr V. Ilyaskin   +7 more
core   +1 more source

Molecular determinants of ASIC1 modulation by divalent cations

Scientific Reports
Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. ASIC gating is modulated by divalent cations as well as small molecules; however, the molecular determinants of gating modulation by divalent ...
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael P. Maher   +11 more
doaj   +1 more source

Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2025.3

IUPHAR/BPS Guide to Pharmacology CITE
Acid-sensing ion channels (ASICs, nomenclature as agreed by NC-IUPHAR [52, 2, 3]) are members of a Na+ channel superfamily that includes the epithelial Na+ channel (ENaC), the FMRF-amide activated channel (FaNaC) of invertebrates, the degenerins (DEG) of Caenorhabitis elegans, channels in Drosophila melanogaster and the mammalian bile acid-activated ...
Stephan Kellenberger, Lachlan D. Rash
openaire   +3 more sources

Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain

Frontiers in Neuroscience, 2019
Acid-sensing ion channels (ASICs) are important acid sensors involved in neural modulation in the central nervous system and pain-associated tissue acidosis in the peripheral system.
Chu-Ting Chang, Sitt Wai Fong, Sitt Wai Fong, Cheng-Han Lee, Yu-Chia Chuang, Shing-Hong Lin, Shing-Hong Lin, Chih-Cheng Chen, Chih-Cheng Chen   +8 more
doaj   +1 more source

Acid-Sensing Ion Channels: A Novel Therapeutic Target for Pain and Anxiety

, 2014
The acid-sensing ion channel (ASIC) has emerged as a novel type of ion channel that is activated by extracellular protons as well as nonproton ligands.
Li, Wei-Guang, Xu, Tian-Le
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Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a [PDF]

, 2015
Background and PurposeThe spider-venom peptide PcTx1 is the most potent and selective inhibitor of acid-sensing ion channel (ASIC) 1a. It has centrally acting analgesic activity and is neuroprotective in rodent models of ischaemic stroke.
Saez, Natalie J., Mark, Alan E., Rash, Lachlan D., King, G., Mobli, Mehdi, Chassagnon, Irene R., Cristofori-Armstrong, B., Mobli, M., Lin, X., Rash, L., Saez, N., Chassagnon, I., Deplazes, Evelyne, Mark, A., Lin, Xiaozhen, Cristofori-Armstrong, Ben, King, Glenn F.   +16 more
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Peripheral and central mechanisms in acid induced visceral pain hypersensitivity in the human oesophagus

, 2010
PhDIntroduction: Gastro-oesophageal reflux disease (GORD) affects 40% of Western populations. Many symptoms persist despite the resolution of inflammation or acid exposure.
Chua, Yang Chong
core  

Metabolomics study of APETx2 post-conditioning on myocardial ischemia-reperfusion injury

Frontiers in Pharmacology
BackgroundAcid-sensing ion channels are activated during myocardial ischemia and are implicated in the mechanism of myocardial ischemia-reperfusion injury (MIRI).
Jing Li, Jing Li, Jing Li, Yiyong Wei, Yi Wang, Yue Zhang, Ying Xu, Huanhuan Ma, Lulin Ma, Qingfan Zeng, Qingfan Zeng   +10 more
doaj   +1 more source

Small Molecule Inhibitors of Acid Sensing Ion Channel-1

, 2010
Acid Sensing Ion Channel 1 is one of the many proteins in the Epithelial Sodium Channel/Degenerin family. The proteins in this family interact to form cation channels with unique biophysical properties and can all be inhibited by the small molecule ...
Qadri, Yawar J
core