Results 111 to 120 of about 3,306 (206)

Identification of a novel allosteric modulator of acid-sensing ion channel 3

, 2016
Acid-sensing ion channels (ASICs) are sodium selective channels that belong to the ENac/DEG family of ion channels. They are sensitive to changes in extracellular pH and are expressed in both the central and peripheral nervous system.
Gonzales, Eric PhD, Agharkar, Amruta S.
core  

Coupling between NMDA Receptor and Acid-Sensing Ion Channel Contributes to Ischemic Neuronal Death

, 2005
SummaryAcid-sensing ion channels (ASICs) composed of ASIC1a subunit exhibit a high Ca2+ permeability and play important roles in synaptic plasticity and acid-induced cell death.
Lin Xu, Xu, Lin, Zhang, Guang-Yi, De-Guang Wang, Tian-Le Xu, Jun Gao, Xu, Tian-Le, Duan, Bo, Wang, De-Guang, Gao, Jun, Deng, Xiao-Hong, Bo Duan, Guang-Yi Zhang, Xiao-Hong Deng   +13 more
core   +1 more source

The Conorfamide RPRFa Stabilizes the Open Conformation of Acid-Sensing Ion Channel 3 via the Nonproton Ligand–Sensing Domain

, 2018
Acid-sensing ion channel 3 (ASIC3) is a proton-gated Na+ channel with important roles in pain. ASIC3 quickly desensitizes in less than a second, limiting its capacity to sense sustained acidosis during pain.
Gründer, Stefan, Margreiter, Michael A., Reiners, Melissa, Oslender-Bujotzek, Adrienne, Schmidt, Axel, Rossetti, Giulia   +5 more
core   +1 more source

Proteolytic Cleavage of Human Acid-sensing Ion Channel 1 by the Serine Protease Matriptase

, 2010
Acid-sensing ion channel 1 (ASIC1) is a H+-gated channel of the amiloride-sensitive epithelial Na+ channel (ENaC)/degenerin family. ASIC1 is expressed mostly in the central and peripheral nervous system neurons.
Biljana Jovov, Arun K. Rooj, Jovov, Biljana, Fuller, Catherine M., Rooj, Arun K., Clark, Edlira B., Benos, Dale J., Catherine M. Fuller, Edlira B. Clark, Dale J. Benos   +9 more
core   +1 more source

Blocking acid-sensing ion channel 1a attenuates bilirubin-induced ototoxicity in cochlear organotypic culture

Fundamental Research
Neonatal hyperbilirubinemia leads to neural dysfunction, including sensorineural hearing loss. Our previous studies demonstrated that elevated bilirubin induced apoptotic pathway activation and led to cell malformation in spiral ganglion neurons of ...
Yazhi Xing, Jia Jia, Ling Zhang, Fei Sun, Zhengnong Chen, Dalian Ding, Di Qian, Jianning Zhang, Haibo Ye, Haibo Shi, Shankai Yin   +10 more
doaj   +1 more source

Acid-sensing ion channel 2 (asic 2) and trkb interrelationships within the intervertebral disc.

International journal of clinical and experimental pathology, 2015
The cells of the intervertebral disc (IVD) have an unusual acidic and hyperosmotic microenvironment. They express acid-sensing ion channels (ASICs), gated by extracellular protons and mechanical forces, as well as neurotrophins and their signalling receptors. In the nervous tissues some neurotrophins regulate the expression of ASICs.
Cuesta, Antonio, Viña Fernández, Eliseo, Cabo Pérez, Roberto, Vázquez, Gorka, Cobo, Ramón, García Suárez, Olivia, García Cosamalón, José, Vega Álvarez, José Antonio   +7 more
openaire   +2 more sources

Inhibition of acid sensing ion channel currents by lidocaine in cultured mouse cortical neurons

, 2011
Background: Lidocaine is a local anesthetic that has multiple pharmacological effects including antiarrhythmia, antinociception, and neuroprotection. Acid sensing ion channels (ASICs) are proton-gated cation channels that belong to the epithelial sodium ...
Samaneh Maysami, Xiangping Chu, Jun Lin, Lin, Jun, Maysami, Samaneh, Hongfang Si, Simon, Roger P., Zhigang Xiong, Chu, Xiangping, Si, Hongfang, Li, Minghua, Roger P. Simon, James E. Cottrell, Cottrell, James E., Xiong, Zhigang, Minghua Li   +15 more
core   +1 more source

Extracellular Acidosis Increases Neuronal Cell Calcium By Activating Acid-Sensing Ion Channel 1a

, 2004
Acid-sensing ion channel (ASIC) 1a subunit is expressed in synapses of central neurons where it contributes to synaptic plasticity. However, whether these channels can conduct Ca2+ and thereby raise the cytosolic Ca2+ concentration, [Ca2+]c, and possibly
Abboud, Francois M., Leonard, A. Soren, Petroff, Elena, Welsh, Michael J., Schnizler, Mikael K.   +4 more
core   +1 more source

Insulin enhances acid-sensing ion channel currents in rat primary sensory neurons

Insulin has been shown to modulate neuronal processes through insulin receptors. The ion channels located on neurons may be important targets for insulin/insulin receptor signaling.
Ting-Ting Liu, Huan Yuan, Xue-Mei Li, Chun-Yu Qiu, Qing-Rui Qin, Zhong-Qing Xu, Wang-Ping Hu   +6 more
core   +1 more source

Modulación histaminérgica de la corriente ASIC en neuronas aferentes vestibulares

, 2018
"El sistema vestibular detecta aceleraciones angulares y lineales, gracias a los cinco órganos que lo conforman, tres canales semicirculares y dos órganos otolíticos.
Sánchez Martínez, Salomón, SANCHEZ MARTINEZ, SALOMON; 772234   +1 more
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