Results 101 to 110 of about 3,306 (206)

Acid-sensing ion channels: trafficking and synaptic function

Molecular Brain, 2013
Extracellular acidification occurs in the brain with elevated neural activity, increased metabolism, and neuronal injury. This reduction in pH can have profound effects on brain function because pH regulates essentially every single biochemical reaction.
Zha Xiang-ming
doaj   +1 more source

Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel-3 as a potential therapeutic target

, 2016
The aetiology of intervertebral disc (IVD) degeneration remains poorly understood. Painful IVD degeneration is associated with an acidic intradiscal pH but the response of NP cells to this aberrant microenvironmental factor remains to be fully ...
Gilbert, Hamish, Hoyland, Judith A., Richardson, Stephen M., Baird, Pauline, Gilbert, Hamish T.J., Richardson, Stephen; id_orcid, Hodson, Nathan; id_orcid, Hoyland, Judith, Hodson, Nathan   +8 more
core   +1 more source

The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis

Journal of Experimental & Clinical Cancer Research, 2017
Background The tumor acidic microenvironment, a common biochemical event in solid tumors, offers evolutional advantage for tumors cells and even enhances their aggressive phenotype.
Zhi-hang Zhou, Jin-wen Song, Wen Li, Xue Liu, Liu Cao, Lu-ming Wan, Ying-xia Tan, Shou-ping Ji, Yu-mei Liang, Feng Gong   +9 more
doaj   +1 more source

Multiple Modulation of Acid-Sensing Ion Channel 1a by the Alkaloid Daurisoline

Biomolecules, 2019
Acid-sensing ion channels (ASICs) are proton-gated sodium-selective channels that are expressed in the peripheral and central nervous systems. ASIC1a is one of the most intensively studied isoforms due to its importance and wide representation in ...
Dmitry I. Osmakov, Sergey G. Koshelev, Ekaterina N. Lyukmanova, Mikhail A. Shulepko, Yaroslav A. Andreev, Peter Illes, Sergey A. Kozlov   +6 more
doaj   +1 more source

Stoichiometry of Acid-Sensing Ion Channel (ASIC) Pharmacology

Biophysical Journal, 2020
Matthew L. Rook, David M. MacLean
openaire   +1 more source

Role of Acid-sensing Ion Channels (ASICs) in the Vascular Endothelial Cells Injury of Henoch- Schonlein Purpura Children

International Journal of Clinical & Medical Allergy, 2016
Objective: Acid-sensing ion channels (ASICs) are cationic channels that are activated by extracellular acidification. ASICs are widely expressed in the peripheral and central nervous systems and participate in many important physiological and pathological processes, such as synaptic plasticity, cerebral ischemia, and pain.
Li-ping Yuan, Qi-di Peng, Yan Bo, Guo Xiao-yan, Hu Bo   +4 more
openaire   +2 more sources

Acid-sensing (proton-gated) ion channels (ASICs) in GtoPdb v.2025.4

IUPHAR/BPS Guide to Pharmacology CITE
Acid-sensing ion channels (ASICs, nomenclature as agreed by NC-IUPHAR [52, 2, 3]) are members of a Na+ channel superfamily that includes the epithelial Na+ channel (ENaC), the FMRF-amide activated channel (FaNaC) of invertebrates, the degenerins (DEG) of Caenorhabditis elegans, channels in Drosophila melanogaster and the mammalian bile acid-activated ...
Stephan Kellenberger, Lachlan D. Rash
openaire   +1 more source

Characterization of acid sensing ion channel (ASIC) in mouse olfactory bulb

This study examined the role of acid- sensing ion channels (ASICs) in interneuron synaptic modulation. ASICS are ultra fine discriminators of acidic conditions in the neuronal microenvironment.
Kratzer, Eric Martin
core  

ASIC currents in cultured primate retinal amacrine/ganglion cells

Physiological Reports
Acid‐sensing ion channels (ASICs) are proton‐gated cation channels belonging to the epithelial Na + channel/degenerin superfamily. In the CNS, ASICs are involved in synaptic plasticity, learning/memory, and acidosis‐mediated injury.
Talib Saafir, Tiandong Leng, Koichi Inoue, Zhi‐Gang Xiong, Peter MacLeish   +4 more
doaj   +1 more source

α-linolenic acid-induced facilitation of GABAergic synaptic transmission is mediated via acid-sensing ion channel (ASIC1a) activity in the basolateral amygdala

Experimental Biology and Medicine
Epilepsy affects more than 70 million people worldwide. A seizure focus that develops in different cortical brain regions can present as either focal or generalized seizures.
Volodymyr I. Pidoplichko, Taiza H. Figueiredo, Maria F. M. Braga, Ann M. Marini   +3 more
doaj   +1 more source