Results 71 to 80 of about 3,306 (206)

PhcrTx2, a New Crab-Paralyzing Peptide Toxin from the Sea Anemone Phymanthus crucifer

Toxins, 2018
Sea anemones produce proteinaceous toxins for predation and defense, including peptide toxins that act on a large variety of ion channels of pharmacological and biomedical interest. Phymanthus crucifer is commonly found in the Caribbean Sea; however, the
Armando Alexei Rodríguez, Anoland Garateix, Emilio Salceda, Steve Peigneur, André Junqueira Zaharenko, Tirso Pons, Yúlica Santos, Roberto Arreguín, Ludger Ständker, Wolf-Georg Forssmann, Jan Tytgat, Rosario Vega, Enrique Soto   +12 more
doaj   +1 more source

Unraveling Inflammatory Pain: A Narrative Review of Molecular Pathways and Multidisciplinary Treatments

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Inflammatory pain is a widespread global health concern arising from complex molecular pathways triggered by a consequence of tissue damage and immune activation. It significantly impacts quality of life and functional outcomes, necessitating a comprehensive understanding of underlying mechanisms and multidisciplinary approaches for
Fatma Mohamed Elmansy, Mohamed Goda Elbqry, Saddam Ahmed Al‐Ahdal, Fatima S. O. Ashmieg, Patience Osose Nasir, Nasiru Mohammed Abdullahi, Mohammed Nader Shalaby   +6 more
wiley   +1 more source

Proton binding sites involved in the activation of acid-sensing ion channel ASIC2a

, 2007
Most acid-sensing ion channel (ASIC) subunits are activated by protons, but ASIC2b (a splice variant of ASIC2a) is acid-insensitive. Differences in protonatable residues between the extracellular loop regions of ASIC2a and ASIC2b may explain this ...
Zhang, Xuming, Cadiou, Hervé, McNaughton, Peter A., Smith, Ewan St. J.   +3 more
core   +1 more source

Experimental High‐Throughput Electrochemistry

ChemElectroChem, Volume 13, Issue 9, 5 May 2026.
This review highlights experimental high‐throughput electrochemistry as a powerful approach to accelerate electrochemical research. Key technologies such as automated platforms, microelectrode arrays, and machine learning‐based optimization are discussed, with a focus on applications in electrocatalysis, battery research, and electrosynthesis ...
Jens Noack
wiley   +1 more source

Trypsin cleaves acid-sensing ion channel 1a in a domain that is critical for channel gating.

, 2006
Acid-sensing ion channels (ASICs) are neuronal Na(+) channels that are members of the epithelial Na(+) channel/degenerin family and are transiently activated by extracellular acidification.
Weder, G., Vukicevic, M., Boillat, A., Boesch, A., Kellenberger, S.   +4 more
core   +1 more source

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, Volume 13, Issue 27, 13 May 2026.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers.

, 2018
Acid-sensing ion channels (ASICs) form both homotrimeric and heterotrimeric ion channels that are activated by extracellular protons and are involved in a wide range of physiological and pathophysiological processes, including pain and anxiety.

core   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

Acid-Sensing Ion Channels and Mechanosensation

, 2021
Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are activated by pH drops and nonproton ligands. They are part of the degenerin/epithelial sodium channel superfamily due to their sodium permeability. Predominantly expressed
Nina Ruan, Jacob Tribble, Xiang-Ping Chu, Andrew M. Peterson, John Q. Wang, Qian Jiang   +5 more
core   +1 more source

Characterization of cutaneous and articular sensory neurons

Molecular Pain, 2016
Background A wide range of stimuli can activate sensory neurons and neurons innervating specific tissues often have distinct properties. Here, we used retrograde tracing to identify sensory neurons innervating the hind paw skin (cutaneous) and ankle/knee
Ines da Silva Serra MPharm, Zoé Husson MSc, PhD, Jonathan D. Bartlett, Ewan St. John Smith MPharmacol, PhD   +3 more
doaj   +1 more source