Results 161 to 170 of about 8,571 (202)

Hematopoietic stem cell transplantation leads to biochemical and functional correction in two mouse models of acid ceramidase deficiency. [PDF]

Mol Ther
Rybova J, Sundararajan T, Kuchar L, Dlugi TA, Ruzicka P, McKillop WM, Medin JA.   +6 more
europepmc   +1 more source

Acid ceramidase expression reduces IFNγ secretion by mouse CD4⁺ T cells and is crucial for maintaining B-cell numbers in mice. [PDF]

Front Immunol
Mandasari P, Hollmann C, Zaidi RH, Löw S, Schrama J, Wigger D, Schumacher F, Kleuser B, Beyersdorf N.   +8 more
europepmc   +1 more source

Regulation of Retinoid-Mediated Signaling Involved in Skin Homeostasis by RAR and RXR Agonists/Antagonists in Mouse Skin [PDF]

, 2019
de Lera, Ángel R., Gericke, Janine, Ittensohn, Jan, Mihály, Johanna, Rühl, Ralph, Töröcsik, Dániel, Álvarez, Rosana, Álvarez, Susana   +7 more
core   +1 more source

Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway [PDF]

, 2004
Chen, Shawei, Han, Xianlin, Hsu, Chung Y., Ku, Grace, Lee, Jin-Moo, Lee, Jiunn-Tay, Xu, Jan, Yang, Ding-I   +7 more
core   +1 more source

Inhibition of acid ceramidase as a therapeutic strategy for Niemann-Pick C disease

Haynes I, Ward SE, Jones DH, Lloyd-Evans E, Waller-Evans H.   +4 more
europepmc   +1 more source

Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift [PDF]

core   +1 more source

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The molecular medicine of acid ceramidase

Biological Chemistry, 2015
Abstract Acid ceramidase (N-acylsphingosine deacylase, EC 3.5.1.23; AC) is the lipid hydrolase responsible for the degradation of ceramide into sphingosine and free fatty acids within lysosomes. The enzymatic activity was first identified over four decades ago and is deficient in two rare inherited disorders, Farber lipogranulomatosis (Farber disease ...
Michael, Frohbergh, Xingxuan, He, Edward H, Schuchman   +2 more
openaire   +2 more sources

Acid and alkaline ceramidases of rat tissues

Biochemistry and Cell Biology, 1986
Ceramidase (N-acylsphingosine deacylase) was measured in rat tissue homogenates with N-[1-14C]oleoyl- and N-[9,10-3H]palmitoyl-sphingosine. Two activities were observed with pH optima of approximately 5 and 8. The activity at pH 8 exceeded that at pH 5 in all tissues and tissue areas examined, and both activities decreased in the following order ...
M W, Spence, S, Beed, H W, Cook
openaire   +2 more sources