Results 91 to 100 of about 2,680,532 (210)

Relationship Between Plasma Acid Sphingomyelinase and Alteration in Taste and Smell as Indicator of Long COVID in Pregnant Women

Reports
Background: Persistent alterations in taste and smell affect a significant proportion of individuals following COVID-19, representing a component of post-acute COVID-19 syndrome, commonly referred to as long COVID.
Federico Fiorani, Giulia Moretti, Laura Cerquiglini, Chiara Gizzi, Giulia Gizzi, Paola Signorelli, Samuela Cataldi, Tommaso Beccari, Elisa Delvecchio, Claudia Mazzeschi, Stefania Troiani, Elisabetta Albi   +11 more
doaj   +1 more source

Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology

CPT: Pharmacometrics & Systems Pharmacology, 2018
Acid sphingomyelinase deficiency (ASMD) is a rare lysosomal storage disorder with heterogeneous clinical manifestations, including hepatosplenomegaly and infiltrative pulmonary disease, and is associated with significant morbidity and mortality ...
Chanchala D. Kaddi, Bradley Niesner, Rena Baek, Paul Jasper, John Pappas, John Tolsma, Jing Li, Zachary van Rijn, Mengdi Tao, Catherine Ortemann‐Renon, Rachael Easton, Sharon Tan, Ana Cristina Puga, Edward H. Schuchman, Jeffrey S. Barrett, Karim Azer   +15 more
doaj   +1 more source

Association Between the Root Canal Microbiome and Apical Lesion Size: An Observational Shotgun Metagenomic Study

International Endodontic Journal, Volume 59, Issue 10, Page 2211-2222, October 2026.
ABSTRACT Aim The aim was to characterize the taxonomic and functional composition of the microbiome involved in primary endodontic infections and to evaluate their association with the periapical lesion size using shotgun metagenomic sequencing. Methodology Samples from primary root canal infections diagnosed with apical periodontitis were analysed ...
Virginia Pérez‐Carrasco, David Uroz‐Torres, Ana Soriano‐Lerma, Miguel Soriano, Jose Antonio García‐Salcedo, Maria Teresa Arias‐Moliz   +5 more
wiley   +1 more source

A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products

Journal of Lipid Research, 2006
Previous studies from our laboratory and others presented evidence that oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylcholine (OxPAPC) and oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylethanolamine can inhibit ...
Kimberly A. Walton, Bogdan G. Gugiu, Miracle Thomas, Robert J. Basseri, Daniel R. Eliav, Robert G. Salomon, Judith A. Berliner   +6 more
doaj   +1 more source

Identifikation neuer klinischer Anwendungen für Saure Sphingomyelinase Inhibitoren [PDF]

, 2017
Acid sphingomyelinase is a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide. Acid sphingomyelinase/ceramide have been implicated in the pathogenesis of a number of different diseases.
Beckmann, Nadine
core  

Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets

, 2017
Pulmonary complications from stored blood products are the leading cause of mortality related to transfusion. Transfusion-related acute lung injury is mediated by antibodies or bioactive mediators, yet underlying mechanisms are incompletely understood ...
Kleuser, Burkhard (Prof. Dr. rer. nat.), Arenz, Christoph, Japtok, Lukasz (Prof. Dr.), Mark J. McVey, Michael Kim, Victoria Srbely, Srbely, Victoria, McVey, Mark J., Ori Rotstein, John W. Semple, Semple, John W., Wolfgang M. Kuebler, Arata Tabuchi, Burkhard Kleuser, Kim, Michael, Kuebler, Wolfgang M., Rotstein, Ori, Lukasz Japtok, Christoph Arenz, Tabuchi, Arata   +19 more
core   +1 more source

Mitochondrial ALDH2 improves ß‐cell survival and function against doxorubicin‐induced apoptosis by targeting CK2 signaling

Journal of Diabetes Investigation
Aims The aim of this study was to better understand how the chemotherapy drug doxorubicin contributes to the development of β‐cell dysfunction and to explore its relationship with mitochondrial aldehyde dehydrogenase‐2 (ALDH2).
Udayakumar Karunakaran, Eun Yeong Ha, Suma Elumalai, Kyu Chang Won, Jun Sung Moon   +4 more
doaj   +1 more source

Partial purification and properties of acid sphingomyelinase from rat liver.

Journal of Lipid Research, 1983
Acid sphingomyelinase was purified approximately 5,200-fold from the mitochondria-lysosome-enriched particles of rat liver by sequential chromatography on DEAE-cellulose, octyl-Sepharose, Sephacryl S-300, Concanavalin A-Sepharose, and CM-cellulose.
K Watanabe, N Sakuragawa, M Arima, E Satoyoshi   +3 more
doaj   +1 more source

Curcumin decreases acid sphingomyelinase activity in colon cancer caco-2 cells

, 2007
Curcumin has been shown to inhibit cell growth and induce apoptosis in colon cancer cells. The metabolism of sphingomyelin has implications in the development of colon cancer.
Duan, Rui-Dong, Duan, Rui-Dong,, Cheng, Yajun,, Sternby, Berit,, Kozubek, Agnieszka, Ohlsson, Lena,, Cheng, Yajun, Sternby, Berit, Lund University., Ohlsson, Lena   +9 more
core   +1 more source

Plasma membrane reorganization links acid sphingomyelinase/ceramide to p38 MAPK pathways in endothelial cells apoptosis

, 2017
International audienceThe p38 MAPK signaling pathway is essential in the cellular response to stress stimuli, in particular in the endothelial cells that are major target of external stress. The importance of the bioactive sphingolipid ceramide generated
Dutoit, Soizic,, Niaudet, Colin,, Paris, Francois,, Guillonneau, Maëva, François Paris, Stéphanie Bonnaud, Maëva Guillonneau, Dutoit, Soizic, Colin Niaudet, Dubois, Nolwenn,, Trichet, Valérie, Bonnaud, Stephanie,, Guillonneau, Maeva,, Ripoche, Natacha, Nolwenn Dubois, Paris, François, Dubois, Nolwenn, Marie-Hélène Gaugler, Niaudet, Colin, Bonnaud, Stéphanie, Valérie Trichet, Gaugler, Marie-Hélène, Isabelle Corre, Corre, Isabelle, Gouard, Sebastien,, Gaugler, Marie-Helene,, Trichet, Valerie,, Corre, Isabelle,, Natacha Ripoche, Sébastien Gouard, Ripoche, Natacha,, Soizic Dutoit, Gouard, Sébastien   +32 more
core   +1 more source