Results 81 to 90 of about 2,680,532 (210)

Loss of Acid Ceramidase in Myeloid Cells Protects From Chronic Colitis in IL10‐Deficient Mice

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Acid ceramidase converts ceramide to sphingosine which can then be converted to sphingosine‐1‐phosphate, a bioactive lipid involved in inflammation. Loss of acid ceramidase in myeloid cells protects from chronic colitis by reducing pro‐inflammatory markers, increasing ceramides, and reducing effector immune cells in the colon.
Keila S. Espinoza, Brandon K. Dahl, Ella M. Ryan, Mary R. Gordon, Chelsea L. Doll, Marilyn T. Marron, Cameron A. Beard, Pujarini D. Dey, David G. Besselsen, Richard J. Simpson, Justin M. Snider, Justin E. Wilson, Pawel R. Kiela, Ashley J. Snider   +13 more
wiley   +1 more source

Functional Analysis of the Glycosylation of Murine Acid Sphingomyelinase [PDF]

Journal of Biological Chemistry, 1996
Glycosylation plays a crucial role in glycoprotein stability and its correct folding. Murine acid sphingomyelinase (ASM) is a lysosomal glycoprotein. We studied the functional role of its individual N-linked oligosaccharides needed to maintain enzymatic activity and protein stability. Mutagenized cDNA constructs were heterologously expressed.
D, Newrzella, W, Stoffel
openaire   +2 more sources

Sphingolipids in Major Depression

Neurosignals, 2015
Major depression is one of the most common and severe diseases affecting the world's population. However, the pathogenesis of the disease remains inadequately defined.
Peter L. Jernigan, Richard S. Hoehn, Heike Grassmé, Michael J. Edwards, Christian P Müller, Johannes Kornhuber, Erich Gulbins   +6 more
doaj   +1 more source

Hepatic HIF2α Modulates Extra‐Hepatic Disease‐Associated Phenotypes During Metabolic Dysfunction‐Associated Steatotic Liver Disease

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
High fat, high fructose, high cholesterol “GAN” diet feeding in mice induces MASLD, cardiac dysfunction, loss of lean mass, and hyperinsulinaemia. Hepatocyte‐specific deletion of HIF2α also causes cardiac dysfunction and loss of lean mass but prevents GAN induced hyperinsulinaemia and cardiac sympathetic dominance without preventing MASLD.
Lorenz M. W. Holzner, Rosa M. Korpershoek, Youguo Niu, Anna Cochrane, Paula M. Darwin, Julia Babuta, Areesha Nazeer, Cecilia Castro, Alice P. Sowton, Alice E. Knapton, Benjamin D. Thackray, Julian L. Griffin, Zoe Hall, Dino A. Giussani, Rob C. I. Wüst, Andrew J. Murray   +15 more
wiley   +1 more source

Heparin Can Augment Extracellular Vesicle Yield by Inhibiting Reuptake in Donor Cells During Cell Propagation

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Heparin augments EV yield in culture by inhibiting EV binding to cell‐surface HSPG and masking EV surface. Preventing autocrine and homotypic paracrine EV uptake during cell culture results in EV accumulation and higher yield. Heparin improved EV recovery after storage in NaCl but not in complex media or protein‐rich buffer(Please see Figure 9 for ...
André Cronemberger Andrade, Rodolphe Poupardin, Martin Wolf, Liliia Paniushkina, Karim Selmi, Deepika Kundully Suresh, Nicole Maeding, Heide‐Marie Binder, Janine Zwicklhuber, Sarah Hochmann, André Görgens, Samir El Andaloussi, Katharina Schallmoser, Dirk Strunk   +13 more
wiley   +1 more source

High activity of acid sphingomyelinase in major depression

Journal of Neural Transmission, 2005
Acid sphingomyelinase (A-SMase) and its reaction product ceramide may play a role in the pathophysiology of depressive disorders and in the therapeutic action of antidepressive drugs. In a prospective case-control study, A-SMase activity was measured in peripheral blood mononuclear cells of 17 patients with a major depressive episode who were free of ...
Kornhuber, Johannes, Medlin, A., Bleich, Stefan, Jendrossek, V., Henkel, A. W., Wiltfang, J., Gulbins, E.   +6 more
openaire   +3 more sources

Senescent Cell‐Derived Extracellular Vesicles in Therapy‐Induced Senescence: Immune Remodelling and Emerging Links to Mitochondrial Stress in Cancer

Journal of Extracellular Biology, Volume 5, Issue 10, October 2026.
ABSTRACT Cancer therapy can induce cellular senescence and remodel the tumour microenvironment through the senescence‐associated secretory phenotype (SASP), including its membrane‐enclosed component, senescent cell‐derived extracellular vesicles (senEVs). This review summarizes senEV biogenesis, cargo‐dependent functions, and immune‐remodelling effects
Yongrui Qian, Zirui Weng, Na Li, Yun Zhou, Hailong Pei   +4 more
wiley   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2405-2418, October 2026.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

Curating the Fetal Genome: Experience of the ClinGen Prenatal Gene Curation Expert Panel (GCEP)

Prenatal Diagnosis, Volume 46, Issue 11, Page 1703-1710, October 2026.
ABSTRACT Objective Expert prenatal focused gene‐disease curation is necessary to accurately inform clinical care in the setting of rapidly expanding prenatal genomic sequencing. Methods An international Prenatal Gene Curation Expert Panel assembled and systematically reviewed genes asserted to be associated with prenatal hydrops, stillbirth, or severe ...
Stephanie N. Galloway, Jessica L. Giordano, Carrie Shawber, Natalie Chandler, Lauren Westerfield, Prenatal GCEP Panel members, Ronald J. Wapner, Wendy Chung, Ignatia B. Van den Veyver, Shagun Aggarwal, Caitlin Baptiste, Brenna Boyd, Amanda Buchanan, Alicia Byrne, Imen Chakchouk, David Chitayat, Lyn Chitty, Pinal Dalwadi, Avinash Dharmadhikari, Lilian Downie, Stephanie Dukhovny, Mythily Ganapathi, Kelly Gilmore, Elena Greenfeld, Lylach Haizler‐Cohen, Vaidehi Jobanputra, Gabrielle Litteken, Hannah Perrin, Julie Ratliff, Rebecca Reimers, Erin Riggs, Teresa Sparks, Samantha Stover, Amanda Thomas‐Wilson, Leandra Tolusso, Neeta Vora, Tsegaselassie Workalemahu, Roni Zemet‐Lazar   +37 more
wiley   +1 more source