Results 61 to 70 of about 2,680,532 (210)

Acid sphingomyelinase serum activity in ICU patients with SIRS.

, 2014
Clear boxes represent survivors (n = 9) and grey boxes non-survivors (N = 10).
Supandi Winoto-Morbach (501243), Matthias Kott (657467), Gunnar Elke (449417), Inéz Frerichs (20627), Norbert Weiler (20632), Stefan Schütze (320441), Günther Zick (20626), Maike Reinicke (657468), Dirk Schädler (20628)   +8 more
core   +1 more source

A lipid‐sensitive food choice behavior influences aging outcomes from a longevity‐promoting diet

The FEBS Journal, EarlyView.
C. elegans are exposed to a variety of bacteria in their natural environment and must be able to distinguish between beneficial and detrimental food sources. We show that C. elegans exposed to the bacterium from their natural habitat, Methylobacterium, disrupts lipid homeostasis, causing worms to avoid this bacterial species and choose the laboratory ...
Nicole L. Stuhr, Carmen M. Ramos, Chris D. Turner, Alexander A. Soukas, Sean P. Curran   +4 more
wiley   +1 more source

Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide

, 2018
Staphylococcus aureus ( S. aureus ) infections are among the most common and severe infections, garnering notoriety in an era of increasing resistance to antibiotics.
Michael J. Edwards, Marcus Kohnen, Charles C. Caldwell, Aaron Seitz, Katrin Anne Becker, Hannes Kemper, Martin Fraunholz, Björn Fahsel, Barbara Wilker, Cao Li, Simone Keitsch, Carolin Sehl, Joelina Mayeres, Matthias Soddemann, Heike Grassmé, Erich Gulbins   +15 more
core   +1 more source

Cytotoxicity Profiling of Tenacibaculum Extracellular Products on Chinook Salmon (Oncorhynchus tshawytscha) Gill Cell Line, OTgill1PFR

Journal of Fish Diseases, EarlyView.
ABSTRACT Tenacibaculosis is an important disease of marine fishes caused by bacteria of the genus Tenacibaculum. Pathogenic Tenacibaculum species or serotypes, including Tenacibaculum maritimum, T. dicentrarchi, T. finnmarkense and T. soleae, have been isolated from farmed Chinook salmon (Oncorhynchus tshawytscha) during disease outbreaks in Aotearoa ...
Bjorn Böhmert, Michael Algie, Karthiga Kumanan, Kate S. Hutson, Georgina C. Dowd   +4 more
wiley   +1 more source

Platelet‐activating factor‐receptor signaling mediates solar‐simulated light‐induced extracellular vesicle release in human keratinocytes

Photochemistry and Photobiology, EarlyView.
Solar‐simulated light (SSL) promotes extracellular vesicle (EV) release from keratinocytes through a UVB‐driven, oxidative stress‐dependent pathway. SSL‐induced reactive oxygen species (ROS) generate oxidized glycerophosphocholines with PAF agonistic activity, which activate the Platelet‐activating factor receptor (PAFR), leading to acid ...
Divyanshu Aggarwal, Anita Thyagarajan, Michael G. Kemp, Ravi P. Sahu   +3 more
wiley   +1 more source

Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis ofNeisseria gonorrhoeae [PDF]

, 2000
The interaction with human phagocytes is a hallmark of symptomatic Neisseria gonorrhoeae infections. Gonococcal outer membrane proteins of the Opa family induce the opsonin-independent uptake of the bacteria that relies on CEACAM receptors and an active ...
K. Ferlinz, Gulbins, Erich, Bock, J., Grassmé, H., C.R. Hauck, Ferlinz, Klaus, T.F. Meyer, E. Gulbins, Bock, Jörg, Meyer, T., Grassmé, Heike, H. Grassmé, Hauck, C., Hauck, Christof R., V. Jendrossek, Jendrossek, Verena, Ferlinz, K., Gulbins, E., Jendrossek, V., J. Bock, Meyer, Thomas F.   +20 more
core   +1 more source

Acid sphingomyelinase activity triggers microparticle release from glial cells

, 2009
We have earlier shown that microglia, the immune cells of the CNS, release microparticles from cell plasma membrane after ATP stimulation. These vesicles contain and release IL-1beta, a crucial cytokine in CNS inflammatory events.
L. Riganti, F. Bianco, L. Novellino, E. Menna, L. Saglietti, E. H. Schuchman, C. Verderio, R. Furlan, E.G.I. Clementi, M. Francolini, C. Perrotta, M. Matteoli, Matteoli M, Saglietti L, Verderio C, Schuchman EH, Clementi E, Perrotta C, Riganti L, Menna E, Novellino L, Bianco F, Furlan R, Francolini M   +23 more
core   +1 more source

Acid sphingomyelinase deficiency in Beckwith-Wiedemann syndrome [PDF]

Pathology & Oncology Research, 2000
We report the association of Beckwith-Wiedemann syndrome (BWS) and a residual acid sphingomyelinase (ASM) activity of about 35% in a 23 months old Hungarian boy. Besides the classical triad of exomphalos, macroglossia and gigantism some other BWS-related features: polyhydramnios (known from the praenatal history), hemihypertrophy, craniofacial ...
Réthy, Lajos Attila, Kálmánchey, Rozália, Klujber V, Koós, Rozália, Fekete, György   +4 more
openaire   +2 more sources

Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate

Data in Brief, 2018
Ceramide pathway is a key regulator in cell proliferation and apoptosis and oxidative stress up-regulate ceramides. Acid ceramidase (ACDase), neutral sphingomyelinase (NSMase) and glucosylceramide synthase (GCS) are critical enzymatic systems in ceramide
Mahdi Mashhadi Akbar Boojar, Masoud Mashhadi Akbar Boojar, Sepide Golmohammad, Iraj Bahrehbar   +3 more
doaj   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source