Results 51 to 60 of about 2,680,532 (210)

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Repurposing FIASMAs against Acid Sphingomyelinase for COVID-19: A Computational Molecular Docking and Dynamic Simulation Approach

Molecules, 2023
Over the past few years, COVID-19 has caused widespread suffering worldwide. There is great research potential in this domain and it is also necessary.
Aliza Naz, Sumbul Asif, Khairiah Mubarak Alwutayd, Sara Sarfaraz, Sumra Wajid Abbasi, Asim Abbasi, Abdulkareem M. Alenazi, Mohamed E. Hasan   +7 more
doaj   +1 more source

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis

, 1996
Stress is believed to activate sphingomyelinase to generate ceramide, which serves as a second messenger in initiating the apoptotic response. Conclusive evidence for this paradigm, however, is lacking. In the present study, we used a genetic approach to
McLoughlin, Maureen, Schuchman, Edward H., Cordon-Cardo, Carlos, Peña, Louis A., Kolesnick, Richard, Haimovitz-Friedman, Adriana, Fuks, Zvi, Martin, Seamus, Santana Delgado, María Del Pino, Green, Douglas   +9 more
core   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Acid Sphingomyelinase Regulates Platelet Cell Membrane Scrambling, Secretion, and Thrombus Formation [PDF]

, 2014
Objective-Platelet activation is essential for primary hemostasis and acute thrombotic vascular occlusions. On activation, platelets release their prothrombotic granules and expose phosphatidylserine, thus fostering thrombin generation and thrombus ...
Seizer, Peter, Walker, Britta, Borst, Oliver, Feijge, Marion A. H., Elvers, Margitta, Gulbins, Erich, May, Andreas E., Chatterjee, Madhumita, Heemskerk, Johan W. M., Ferlinz, Klaus, Cosemans, Judith M. E. M.; id_orcid, Schmidt, Sebastian, Lang, Florian, Gawaz, Meinrad, Schaller, Martin, Towhid, Syeda T., Schmidt, Eva-Maria, Leibrock, Christina, Schmid, Evi, Muenzer, Patrick   +19 more
core   +1 more source

Small Molecule Inhibitors of Acid Sphingomyelinase [PDF]

Cellular Physiology and Biochemistry, 2010
Despite of the importance of the acid sphingomyelinase for sphingomyelin homeostasis and sphingolipid signalling, potent and selective inhibitors for this enzyme are rare. An increasing set of data on the inhibition of acid sphingomyelinase in different disease models using indirect inhibitors has been generated and strongly implies acid ...
openaire   +2 more sources

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia

Journal of Translational Medicine, 2019
Background There continues to be a great need for better biomarkers and host-directed treatment targets for community-acquired pneumonia (CAP). Alterations in phospholipid metabolism may constitute a source of small molecule biomarkers for acute ...
Haroon Arshad, Juan Carlos López Alfonso, Raimo Franke, Katina Michaelis, Leonardo Araujo, Aamna Habib, Yuliya Zboromyrska, Eva Lücke, Emilia Strungaru, Manas K. Akmatov, Haralampos Hatzikirou, Michael Meyer-Hermann, Astrid Petersmann, Matthias Nauck, Mark Brönstrup, Ursula Bilitewski, Laurent Abel, Jorg Sievers, Jordi Vila, Thomas Illig, Jens Schreiber, Frank Pessler   +21 more
doaj   +1 more source

Sphingolipids in thyroid eye disease

Frontiers in Endocrinology, 2023
Graves’ disease (GD) is caused by an autoimmune formation of autoantibodies and autoreactive T-cells against the thyroid stimulating hormone receptor (TSHR).
Anne Gulbins, Gina-Eva Görtz, Erich Gulbins, Anja Eckstein   +3 more
doaj   +1 more source

Advances in Radiotherapy for Neoadjuvant Therapy of Stage III Non‐Small Cell Lung Cancer

Cancer Science, EarlyView.
This review summarizes three neoadjuvant radiotherapy techniques for stage III NSCLC, highlighting SFRT's low‐toxicity dual immune‐tumor control benefits and radioimmunotherapy's superior pathological response to guide precise multimodal treatment. ABSTRACT This review aims to systematically summarize the mechanisms of action, clinical evolution, and ...
Qinrong Mao, Yuanchun Yu, Yan Fang, Shaofeng Zhu, Chengjin Tang, Jing Cai   +5 more
wiley   +1 more source