Results 31 to 40 of about 25,568 (180)

TAVI in Patient Suffering from Niemann–Pick Disease (Acid Sphingomyelinase Deficiency) with Concomitant Situs Inversus and Dextrocardia

Cardiology and Therapy, 2023
Acid sphingomyelinase deficiency (ASMD)—also known as Niemann–Pick (NP) disease—is a rare, autosomal recessive disorder which is characterized by deficiency of the lysosomal enzyme acid sphingomyelinase (ASM), resulting in excessive storage of lipids in ...
Daniele De Feo, Anna D’Anzi, Vincenzo Pestrichella, Pietro Scicchitano, Carlo Lafranceschina, Vito Caragnano, Fabio Tiecco, Antonella Scialpi, Giuliana Laronga, Marco Matteo Ciccone, Sabino Iliceto   +10 more
doaj   +1 more source

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure. [PDF]

, 2012
Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide.
Bosman, GJ, Brock, R, Cluitmans, JC, Dinkla, S, Fransen, J, Fuchs, B, Joosten, I, Schiller, J, Tomelleri, C, Verdurmen, WP, Wessels, K   +10 more
core   +1 more source

Bioactive dairy ingredients for food and non-food applications [PDF]

, 2014
Lactobacilli and bifidobacteria are most commonly encountered in the dairy industries, either existing naturally in milk or inoculated as starters in fermented dairy products.
Gan, C., Liong, M.T., Peh, K., Tan, P.
core   +1 more source

Role of Janus-Kinases in Major Depressive Disorder

Neurosignals, 2016
Background/Aims: Major depressive disorder is a severe, common and often chronic disease with a significant mortality due to suicide. The pathogenesis of major depression is still unknown. It is assumed that a reduction of neurogenesis in the hippocampus
Anne Gulbins, Heike Grassmé, Richard Hoehn, Marcus Kohnen, Michael J. Edwards, Johannes Kornhuber, Erich Gulbins   +6 more
doaj   +1 more source

Sphingomyelinase D from loxosceles laeta venom induces the expression of MMP7 in human keratinocytes: contribution to dermonecrosis [PDF]

, 2016
Envenomation by Loxosceles spider is characterized by the development of dermonecrosis. In previous studies, we have demonstrated that increased expression/secretion of matrix metalloproteinases 2 and 9, induced by Loxosceles intermedia venom Class 2 ...
Correa, Mara A., Goncalves-de-Andrade, Rute M., Okamoto, Cinthya K., Tambourgi, Denise V., van den Berg, Carmen W.   +4 more
core   +3 more sources

Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells

Mediators of Inflammation, 2017
Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the ...
Samuela Cataldi, Cataldo Arcuri, Stéphane Hunot, François-Pierre Légeron, Carmen Mecca, Mercedes Garcia-Gil, Andrea Lazzarini, Michela Codini, Tommaso Beccari, Anna Tasegian, Bernard Fioretti, Giovanna Traina, Francesco Saverio Ambesi-Impiombato, Francesco Curcio, Elisabetta Albi   +14 more
doaj   +1 more source

Blockade of Experimental Multiple Sclerosis by Inhibition of the Acid Sphingomyelinase/Ceramide System

Neurosignals, 2017
Background: Multiple sclerosis (MS) is a severe and common autoimmune disorder of the central nervous system. Despite the availability of several novel treatment options, the disease is still poorly controlled, since the pathophysiological mechanisms are
Katrin Anne Becker, Ramona Halmer, Laura Davies, Brian D. Henry, Regan Ziobro-Henry, Yann Decker, Yang Liu, Erich Gulbins, Klaus Fassbender, Silke Walter   +9 more
doaj   +1 more source

Improved sensitivity of an acid sphingomyelinase activity assay using a C6:0 sphingomyelin substrate

Molecular Genetics and Metabolism Reports, 2015
Short-chain C6-sphingomyelin is an artificial substrate that was used in an acid sphingomyelinase activity assay for a pilot screening study of patients with Niemann–Pick disease types A and B.
Wei-Lien Chuang, Joshua Pacheco, Samantha Cooper, Jonathan S. Kingsbury, John Hinds, Pavlina Wolf, Petra Oliva, Joan Keutzer, Gerald F. Cox, Kate Zhang   +9 more
doaj   +1 more source

Plasma membrane sphingomyelin and the regulation of HMG-CoA reductase activity and cholesterol biosynthesis in cell cultures.

Journal of Lipid Research, 1991
We have examined the mechanism of the inhibition of cholesterol synthesis in cells treated with exogenous sphingomyelinase. Treatment of rat intestinal epithelial cells (IEC-6), human skin fibroblasts (GM-43), and human hepatoma (HepG2) cells in culture ...
AK Gupta, H Rudney
doaj   +1 more source

Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage

Cellular Physiology and Biochemistry, 2016
Background/Aims: During storage, units of human red blood cells (pRBCs) experience membrane destabilization and hemolysis which may cause harm to transfusion recipients.
Richard S. Hoehn, Peter L. Jernigan, Alex L. Chang, Michael J. Edwards, Charles C. Caldwell, Erich Gulbins, Timothy A. Pritts   +6 more
doaj   +1 more source