Results 31 to 40 of about 2,680,532 (210)

A Novel Visible Range FRET Probe for Monitoring Acid Sphingomyelinase Activity in Living Cells [PDF]

, 2020
Activity of acid sphingomyelinase has been implicated in a number of diseases like acute lung injury, sepsis or metastasis of melanoma cells. Here, we present a sphingomyelinase FRET probe based on FAM/BODIPY dyes for real‐time monitoring of acid ...
Christian Kappe, Arenz, Christoph, Christoph Arenz, Kappe, Christian, Carpinteiro, Alexander, Alexander Carpinteiro, Mohamed, Zainelabdeen H., Eyad Naser, Naser, Eyad, Zainelabdeen H. Mohamed   +9 more
core   +1 more source

Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma [PDF]

, 2023
: Pancreatic adenocarcinoma (PDAC) is one of the most common cancers worldwide. Unfortunately, the prognosis of PDAC is rather poor, and for instance, in the USA, over 47,000 people die because of pancreatic cancer annually.
Wang J., Patel S. H., Turner K. M., Wilson G. C., Becker K. A., Ahmad S. A., Szabo I., Gulbins E., Xu K., Carpinteiro A.   +9 more
core   +1 more source

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]

, 2010
Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K., Young, Simon A., Young, Simon Alan, Smith, Terry K.; id_orcid, Young, Simon A.; id_orcid   +4 more
core   +1 more source

Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response

Journal of Lipid Research, 2013
Plasma secretion of acid sphingomyelinase is a hallmark of cellular stress response resulting in the formation of membrane embedded ceramide-enriched lipid rafts and the reorganization of receptor complexes.
Nayla Jbeily, Iris Suckert, Falk A. Gonnert, Benedikt Acht, Clemens L. Bockmeyer, Sascha D. Grossmann, Markus F. Blaess, Anja Lueth, Hans-Peter Deigner, Michael Bauer, Ralf A. Claus   +10 more
doaj   +1 more source

Acid sphingomyelinase deficiency ameliorates Farber disease

, 2021
Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan.
Kleuser, Burkhard (Prof. Dr. rer. nat.), Beckmann, Nadine, Kühn, Claudine, Gulbins, Erich, Schulz-Schaeffer, Walter J., Carpinteiro, Alexander, Becker, Katrin Anne, Edwards, Michael J., Kramer, Melanie, Kadow, Stephanie, Schumacher, Fabian (Dr.)   +10 more
core   +1 more source

The acid sphingomyelinase/ceramide system in COVID-19 [PDF]

, 2023
Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide, which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS-CoV-2 uses these platforms for cell entry.
Kornhuber, Johannes, Hoertel, Nicolas, Gulbins, Erich   +2 more
core   +2 more sources

Src Mediates Epigallocatechin-3-O-Gallate-Elicited Acid Sphingomyelinase Activation

Molecules, 2020
Epigallocatechin-3-O-gallate (EGCG) is one of the major bioactive compounds known to be present in green tea. We previously reported that EGCG shows selective toxicity through activation of the protein kinase B (Akt)/cyclic guanosine monophosphate (cGMP)/
Motofumi Kumazoe, Mai Kadomatsu, Jaehoon Bae, Yushi Otsuka, Yoshinori Fujimura, Hirofumi Tachibana   +5 more
doaj   +1 more source

TAVI in Patient Suffering from Niemann–Pick Disease (Acid Sphingomyelinase Deficiency) with Concomitant Situs Inversus and Dextrocardia

Cardiology and Therapy, 2023
Acid sphingomyelinase deficiency (ASMD)—also known as Niemann–Pick (NP) disease—is a rare, autosomal recessive disorder which is characterized by deficiency of the lysosomal enzyme acid sphingomyelinase (ASM), resulting in excessive storage of lipids in ...
Daniele De Feo, Anna D’Anzi, Vincenzo Pestrichella, Pietro Scicchitano, Carlo Lafranceschina, Vito Caragnano, Fabio Tiecco, Antonella Scialpi, Giuliana Laronga, Marco Matteo Ciccone, Sabino Iliceto   +10 more
doaj   +1 more source

Acid Sphingomyelinase-Ceramide System in Bacterial Infections [PDF]

Cellular Physiology and Biochemistry, 2019
Acid sphingomyelinase hydrolyzes sphingomyelin to ceramide and phosphorylcholine. Ceramide molecules spontaneously interact with each other and generate ceramide-enriched membrane domains. These ceramide-enriched domains further fuse, forming large ceramideenriched platforms that participate in the organization of receptors and in the amplification of ...
Cao Li, Anni Wang, Yuqing Wu, Erich Gulbins, Heike Grassmé, Zhigang Zhao   +5 more
doaj   +4 more sources

Role of Janus-Kinases in Major Depressive Disorder

Neurosignals, 2016
Background/Aims: Major depressive disorder is a severe, common and often chronic disease with a significant mortality due to suicide. The pathogenesis of major depression is still unknown. It is assumed that a reduction of neurogenesis in the hippocampus
Anne Gulbins, Heike Grassmé, Richard Hoehn, Marcus Kohnen, Michael J. Edwards, Johannes Kornhuber, Erich Gulbins   +6 more
doaj   +1 more source