Results 31 to 40 of about 15,882 (175)
Acid Sphingomyelinase-Ceramide System in Bacterial Infections [PDF]
Cellular Physiology and Biochemistry, 2019 Acid sphingomyelinase hydrolyzes sphingomyelin to ceramide and phosphorylcholine. Ceramide molecules spontaneously interact with each other and generate ceramide-enriched membrane domains. These ceramide-enriched domains further fuse, forming large ceramideenriched platforms that participate in the organization of receptors and in the amplification of ...
Cao Li +5 more
doaj +4 more sources
Mediators of Inflammation, 2017 Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the ...
Samuela Cataldi +14 more
doaj +1 more source
Neurosignals, 2017 Background: Multiple sclerosis (MS) is a severe and common autoimmune disorder of the central nervous system. Despite the availability of several novel treatment options, the disease is still poorly controlled, since the pathophysiological mechanisms are
Katrin Anne Becker +9 more
doaj +1 more source
Improved sensitivity of an acid sphingomyelinase activity assay using a C6:0 sphingomyelin substrate
Molecular Genetics and Metabolism Reports, 2015 Short-chain C6-sphingomyelin is an artificial substrate that was used in an acid sphingomyelinase activity assay for a pilot screening study of patients with Niemann–Pick disease types A and B.
Wei-Lien Chuang +9 more
doaj +1 more source
Journal of Lipid Research, 1991 We have examined the mechanism of the inhibition of cholesterol synthesis in cells treated with exogenous sphingomyelinase. Treatment of rat intestinal epithelial cells (IEC-6), human skin fibroblasts (GM-43), and human hepatoma (HepG2) cells in culture ...
AK Gupta, H Rudney
doaj +1 more source
Small Molecule Inhibitors of Acid Sphingomyelinase [PDF]
Cellular Physiology and Biochemistry, 2010 Despite of the importance of the acid sphingomyelinase for sphingomyelin homeostasis and sphingolipid signalling, potent and selective inhibitors for this enzyme are rare. An increasing set of data on the inhibition of acid sphingomyelinase in different disease models using indirect inhibitors has been generated and strongly implies acid ...
openaire +2 more sources
Neurobiology of DiseaseLoss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. Progranulin mutations cause abnormalities in lysosomal lipid processing, particularly of sphingolipids, major components of neural cell
Nicholas R. Boyle +12 more
doaj +1 more source
The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence
AgriFood: Journal of Agricultural Products for Food, EarlyView.Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John +4 more
wiley +1 more source
Immunoregulatory role of acid sphingomyelinase in allergic asthma [PDF]
Immunology, 2019 SummaryAcid sphingomyelinase (ASM) is one of the enzymes that catalyzes the breakdown of sphingomyelin to ceramide and phosphorylcholine. In this study, we aimed at elucidating the role of ASM in allergic asthma. We used an ovalbumin‐induced murine model of asthma where we compared wild‐type and ASM‐deficient mice.
Nina Sopel +7 more
openaire +2 more sources
Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage
Cellular Physiology and Biochemistry, 2016 Background/Aims: During storage, units of human red blood cells (pRBCs) experience membrane destabilization and hemolysis which may cause harm to transfusion recipients.
Richard S. Hoehn +6 more
doaj +1 more source