Results 11 to 20 of about 15,882 (175)

Regulation of Arthritis Severity by the Acid Sphingomyelinase [PDF]

Cellular Physiology and Biochemistry, 2017
Background/Aims: Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints. Treatment is hampered by the lack of a cure and current disease-modifying drugs are associated with potentially severe toxicities ...
Nadine Beckmann, Katrin Anne Becker, Silke Walter, Jan U. Becker, Melanie Kramer, Gabriele Hessler, Stefanie Weber, Joachim R. Göthert, Klaus Fassbender, Erich Gulbins, Alexander Carpinteiro   +10 more
doaj   +4 more sources

Crystal structure of mammalian acid sphingomyelinase [PDF]

Nature Communications, 2016
Mutations in acid sphingomyelinase result in toxic accumulation of sphingomyelin and cause Niemann-Pick disease. Here, the authors report structures of mammalian acid sphingomyelinase, which reveal details of the molecular mechanism of acid ...
Alexei Gorelik, Katalin Illes, Leonhard X. Heinz, Giulio Superti-Furga, Bhushan Nagar   +4 more
doaj   +3 more sources

Identification of novel functional inhibitors of acid sphingomyelinase.

PLoS ONE, 2011
We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), therefore, can be potentially used to ...
Johannes Kornhuber, Markus Muehlbacher, Stefan Trapp, Stefanie Pechmann, Astrid Friedl, Martin Reichel, Christiane Mühle, Lothar Terfloth, Teja W Groemer, Gudrun M Spitzer, Klaus R Liedl, Erich Gulbins, Philipp Tripal   +12 more
doaj   +5 more sources

Effect of saposins on acid sphingomyelinase [PDF]

Biochemical Journal, 1993
The effect of saposins (A, B, C and D) on acid sphingomyelinase activity was determined using a crude human kidney sphingomyelinase preparation and a purified sphingomyelinase preparation from human placenta. Saposin D stimulated the activity of the crude enzyme by increasing its apparent Km and Vmax. values for sphingomyelin hydrolysis.
M, Tayama, S, Soeda, Y, Kishimoto, B M, Martin, J W, Callahan, M, Hiraiwa, J S, O'Brien   +6 more
openaire   +2 more sources

Physiological functions and therapeutic applications of neutral sphingomyelinase and acid sphingomyelinase

Biomedicine & Pharmacotherapy, 2021
Sphingomyelin (SM) can be converted into ceramide (Cer) by neutral sphingomyelinase (NSM) and acid sphingomyelinase (ASM). Cer is a second messenger of lipids and can regulate cell growth and apoptosis. Increasing evidence shows that NSM and ASM play key roles in many processes, such as apoptosis, immune function and inflammation.
Hongjiao, Xiang, Shengjie, Jin, Fenglang, Tan, Yifan, Xu, Yifei, Lu, Tao, Wu   +5 more
openaire   +2 more sources

Acid sphingomyelinase in macrophage biology [PDF]

Cellular and Molecular Life Sciences, 2011
Macrophages play a central role in innate immune responses, in disposal of cholesterol, and in tissue homeostasis and remodeling. To perform these vital functions macrophages display high endosomal/lysosomal activities. Recent studies have highlighted that acid sphingomyelinase (ASMase), which generates ceramide from sphingomyelin, is involved in ...
Jean-Philip, Truman, Mohammed M, Al Gadban, Kent J, Smith, Samar M, Hammad   +3 more
openaire   +2 more sources

Human acid sphingomyelinase. [PDF]

European journal of biochemistry, 2003
Human acid sphingomyelinase (haSMase, EC 3.1.4.12) catalyzes the lysosomal degradation of sphingomyelin to ceramide and phosphorylcholine. An inherited haSMase deficiency leads to Niemann-Pick disease, a severe sphingolipid storage disorder. The enzyme was purified and cloned over 10 years ago.
Stephanie, Lansmann, Christina G, Schuette, Oliver, Bartelsen, Joerg, Hoernschemeyer, Thomas, Linke, Judith, Weisgerber, Konrad, Sandhoff   +6 more
openaire   +4 more sources

A photocaged inhibitor of acid sphingomyelinase

Chemical Communications, 2020
An esterase-labile, photocaged inhibitor provides spatiotemporal control over acid sphingomyelinase in living cells.
Kevin Prause, Gita Naseri, Fabian Schumacher, Christian Kappe, Burkhard Kleuser, Christoph Arenz   +5 more
openaire   +3 more sources

Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System

Neurosignals, 2016
Background: Melatonin has been shown to have antidepressive effects. We tested whether melatonin inhibits the acid sphingomyelinase/ceramide system and mediates its antidepressive effects via inhibition of the acid sphingomyelinase and a reduction of ...
Richard Hoehn, Marlene Monse, Ella Pohl, Sina Wranik, Barbara Wilker, Simone Keitsch, Matthias Soddemann, Johannes Kornhuber, Marcus Kohnen, Michael J. Edwards, Heike Grassmé, Erich Gulbins   +11 more
doaj   +1 more source

Sphingolipid metabolism correlates with cerebrospinal fluid Beta amyloid levels in Alzheimer's disease. [PDF]

PLoS ONE, 2015
Sphingolipids are important in many brain functions but their role in Alzheimer's disease (AD) is not completely defined. A major limit is availability of fresh brain tissue with defined AD pathology. The discovery that cerebrospinal fluid (CSF) contains
Alfred N Fonteh, Cora Ormseth, Jiarong Chiang, Matthew Cipolla, Xianghong Arakaki, Michael G Harrington   +5 more
doaj   +1 more source