Results 11 to 20 of about 2,680,532 (210)
Regulation of Arthritis Severity by the Acid Sphingomyelinase [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints. Treatment is hampered by the lack of a cure and current disease-modifying drugs are associated with potentially severe toxicities ...
Nadine Beckmann +10 more
doaj +5 more sources
Identification of novel functional inhibitors of acid sphingomyelinase. [PDF]
PLoS ONE, 2011 We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), therefore, can be potentially used to ...
Johannes Kornhuber +12 more
doaj +6 more sources
Crystal structure of mammalian acid sphingomyelinase [PDF]
Nature Communications, 2016 Mutations in acid sphingomyelinase result in toxic accumulation of sphingomyelin and cause Niemann-Pick disease. Here, the authors report structures of mammalian acid sphingomyelinase, which reveal details of the molecular mechanism of acid ...
Alexei Gorelik +4 more
doaj +3 more sources
Apoptosis and signalling in acid sphingomyelinase deficient cells [PDF]
BMC Cell Biology, 2001 Background Recent evidence suggests that the activation of a non-specific lipid scramblase during apoptosis induces the flipping of sphingomyelin from the cell surface to the cytoplasmic leaftet of the plasma membrane. Inner leaflet sphingomyelin is then
Sillence Dan J
doaj +2 more sources
Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls [PDF]
International Journal of COPD, 2016 Simon R Lea,1,* Hannah J Metcalfe,1,* Jonathan Plumb,1 Christian Beerli,2 Chris Poll,3 Dave Singh,1 Katharine H Abbott-Banner3 1Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre,
Lea SR +6 more
doaj +3 more sources
Cellular Physiology and Biochemistry, 2017 Background/Aims: Staphylococcus aureus (S. aureus) infections are a major clinical problem and range from mild skin and soft-tissue infections to severe and even lethal infections such as pneumonia, endocarditis, sepsis, osteomyelitis, and toxic shock ...
Jie Ma +5 more
doaj +2 more sources
JIMD Reports, 2021 Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disease (LSD) in which sphingomyelin accumulates due to deficient acid sphingomyelinase. In the chronic visceral subtype, organ manifestations are generally limited to the spleen, liver, and ...
Eline C. B. Eskes +6 more
doaj +2 more sources
Improved sensitivity of an acid sphingomyelinase activity assay using a C6:0 sphingomyelin substrate
Molecular Genetics and Metabolism Reports, 2015 Short-chain C6-sphingomyelin is an artificial substrate that was used in an acid sphingomyelinase activity assay for a pilot screening study of patients with Niemann–Pick disease types A and B.
Wei-Lien Chuang +9 more
doaj +2 more sources
Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage
Cellular Physiology and Biochemistry, 2016 Background/Aims: During storage, units of human red blood cells (pRBCs) experience membrane destabilization and hemolysis which may cause harm to transfusion recipients.
Richard S. Hoehn +6 more
doaj +2 more sources
Prevalence of Cancer in Acid Sphingomyelinase Deficiency [PDF]
Journal of Clinical Medicine, 2021 Acid sphingomyelinase deficiency (ASMD) is an inherited lysosomal disease characterised by a diffuse accumulation of sphingomyelin that cannot be catabolised into ceramide and phosphocholine. We studied the incidence of cancer in ASMD patients. We retrospectively reviewed the medical records of the adult chronic visceral ASMD patients in our cohort ...
Mauhin, Wladimir +4 more
openaire +3 more sources