Results 21 to 30 of about 2,680,532 (210)

Effect of saposins on acid sphingomyelinase [PDF]

Biochemical Journal, 1993
The effect of saposins (A, B, C and D) on acid sphingomyelinase activity was determined using a crude human kidney sphingomyelinase preparation and a purified sphingomyelinase preparation from human placenta. Saposin D stimulated the activity of the crude enzyme by increasing its apparent Km and Vmax. values for sphingomyelin hydrolysis.
M, Tayama, S, Soeda, Y, Kishimoto, B M, Martin, J W, Callahan, M, Hiraiwa, J S, O'Brien   +6 more
openaire   +2 more sources

Physiological functions and therapeutic applications of neutral sphingomyelinase and acid sphingomyelinase

Biomedicine & Pharmacotherapy, 2021
Sphingomyelin (SM) can be converted into ceramide (Cer) by neutral sphingomyelinase (NSM) and acid sphingomyelinase (ASM). Cer is a second messenger of lipids and can regulate cell growth and apoptosis. Increasing evidence shows that NSM and ASM play key roles in many processes, such as apoptosis, immune function and inflammation.
Hongjiao, Xiang, Shengjie, Jin, Fenglang, Tan, Yifan, Xu, Yifei, Lu, Tao, Wu   +5 more
openaire   +2 more sources

Acid sphingomyelinase in macrophage biology [PDF]

Cellular and Molecular Life Sciences, 2011
Macrophages play a central role in innate immune responses, in disposal of cholesterol, and in tissue homeostasis and remodeling. To perform these vital functions macrophages display high endosomal/lysosomal activities. Recent studies have highlighted that acid sphingomyelinase (ASMase), which generates ceramide from sphingomyelin, is involved in ...
Jean-Philip, Truman, Mohammed M, Al Gadban, Kent J, Smith, Samar M, Hammad   +3 more
openaire   +2 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

A photocaged inhibitor of acid sphingomyelinase

Chemical Communications, 2020
An esterase-labile, photocaged inhibitor provides spatiotemporal control over acid sphingomyelinase in living cells.
Kevin Prause, Gita Naseri, Fabian Schumacher, Christian Kappe, Burkhard Kleuser, Christoph Arenz   +5 more
openaire   +3 more sources

Human acid sphingomyelinase. [PDF]

European journal of biochemistry, 2003
Human acid sphingomyelinase (haSMase, EC 3.1.4.12) catalyzes the lysosomal degradation of sphingomyelin to ceramide and phosphorylcholine. An inherited haSMase deficiency leads to Niemann-Pick disease, a severe sphingolipid storage disorder. The enzyme was purified and cloned over 10 years ago.
Stephanie, Lansmann, Christina G, Schuette, Oliver, Bartelsen, Joerg, Hoernschemeyer, Thomas, Linke, Judith, Weisgerber, Konrad, Sandhoff   +6 more
openaire   +4 more sources

Sphingolipid metabolism correlates with cerebrospinal fluid Beta amyloid levels in Alzheimer's disease. [PDF]

PLoS ONE, 2015
Sphingolipids are important in many brain functions but their role in Alzheimer's disease (AD) is not completely defined. A major limit is availability of fresh brain tissue with defined AD pathology. The discovery that cerebrospinal fluid (CSF) contains
Alfred N Fonteh, Cora Ormseth, Jiarong Chiang, Matthew Cipolla, Xianghong Arakaki, Michael G Harrington   +5 more
doaj   +1 more source

Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic Strategies

Frontiers in Immunology, 2021
Effective treatment strategies for severe coronavirus disease (COVID-19) remain scarce. Hydrolysis of membrane-embedded, inert sphingomyelin by stress responsive sphingomyelinases is a hallmark of adaptive responses and cellular repair.
Murad Abusukhun, Murad Abusukhun, Martin S. Winkler, Stefan Pöhlmann, Stefan Pöhlmann, Onnen Moerer, Konrad Meissner, Björn Tampe, Heike Hofmann-Winkler, Michael Bauer, Michael Bauer, Markus H. Gräler, Markus H. Gräler, Markus H. Gräler, Ralf A. Claus, Ralf A. Claus   +15 more
doaj   +1 more source

Acid Sphingomyelinase Is a Modulator of Contextual Fear

International Journal of Molecular Sciences, 2022
Acid sphingomyelinase (ASM) regulates a variety of physiological processes and plays an important role in emotional behavior. The role of ASM in fear-related behavior has not been investigated so far. Using transgenic mice overexpressing ASM (ASMtg) and ASM deficient mice, we studied whether ASM regulates fear learning and expression of cued and ...
Iulia Zoicas, Johannes Kornhuber
openaire   +2 more sources

Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties [PDF]

, 2015
This work was supported by National Institute of Mental Health grants: P30 MH075673-06 to BSS, CR, NJH and JCM; R01 MH096636 and R01 MH077542 to NJH (http://projectreporter.nih.gov/reporter.​cfm); and The Johns Hopkins Brain Science Institute to BSS ...
Justin C. McArthur (66539), Bandaru, Veera Venkata Ratnam, Graeme W. Rogers (744791), Yoo, Seung-Wan, Seung-Wan Yoo (744790), McArthur, Justin C., Justin C McArthur, Veera Venkata Ratnam Bandaru (193990), Haughey, Norman J., Marigo Stathis, Graeme W Rogers, Figuera-Losada, Mariana, Veera Venkata Ratnam Bandaru, Stathis, Marigo, Norman J Haughey, Slusher, Barbara S., Barbara S Slusher, Barbara S. Slusher (634276), Joelle M Dorskind, Nicholas J Westwood, Seung-Wan Yoo, Norman J. Haughey (193998), Mariana Figuera-Losada (744786), Marigo Stathis (744787), Camilo Rojas (744792), Ajit G. Thomas (744789), Westwood, Nicholas James, Rojas, Camilo, Nicholas J. Westwood (254891), Thomas, Ajit G., Rogers, Graeme Wayne, Mariana Figuera-Losada, Joelle M. Dorskind (744788), Ajit G Thomas, Dorskind, Joelle M., Camilo Rojas, Thomas Ajit G., Rojas Camilo, Westwood Nicholas J., Rogers Graeme W., McArthur Justin C., Stathis Marigo, Yoo Seung-Wan, Figuera-Losada Mariana, Slusher Barbara S., Bandaru Veera Venkata Ratnam, Dorskind Joelle M., Haughey Norman J., Westwood, Nicholas James; id_orcid   +48 more
core   +2 more sources