Results 21 to 30 of about 15,882 (175)

Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic Strategies

Frontiers in Immunology, 2021
Effective treatment strategies for severe coronavirus disease (COVID-19) remain scarce. Hydrolysis of membrane-embedded, inert sphingomyelin by stress responsive sphingomyelinases is a hallmark of adaptive responses and cellular repair.
Murad Abusukhun, Murad Abusukhun, Martin S. Winkler, Stefan Pöhlmann, Stefan Pöhlmann, Onnen Moerer, Konrad Meissner, Björn Tampe, Heike Hofmann-Winkler, Michael Bauer, Michael Bauer, Markus H. Gräler, Markus H. Gräler, Markus H. Gräler, Ralf A. Claus, Ralf A. Claus   +15 more
doaj   +1 more source

Acid Sphingomyelinase Is a Modulator of Contextual Fear

International Journal of Molecular Sciences, 2022
Acid sphingomyelinase (ASM) regulates a variety of physiological processes and plays an important role in emotional behavior. The role of ASM in fear-related behavior has not been investigated so far. Using transgenic mice overexpressing ASM (ASMtg) and ASM deficient mice, we studied whether ASM regulates fear learning and expression of cued and ...
Iulia Zoicas, Johannes Kornhuber
openaire   +2 more sources

The acid sphingomyelinase/ceramide system in COVID-19 [PDF]

Molecular Psychiatry, 2021
AbstractAcid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide, which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS-CoV-2 uses these platforms for cell entry. Lowering the amount of ceramide or ceramide blockade due to inhibitors of ASM, genetic downregulation of ASM, anti-ceramide ...
Johannes Kornhuber, Nicolas Hoertel, Erich Gulbins   +2 more
openaire   +3 more sources

Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response

Journal of Lipid Research, 2013
Plasma secretion of acid sphingomyelinase is a hallmark of cellular stress response resulting in the formation of membrane embedded ceramide-enriched lipid rafts and the reorganization of receptor complexes.
Nayla Jbeily, Iris Suckert, Falk A. Gonnert, Benedikt Acht, Clemens L. Bockmeyer, Sascha D. Grossmann, Markus F. Blaess, Anja Lueth, Hans-Peter Deigner, Michael Bauer, Ralf A. Claus   +10 more
doaj   +1 more source

Apoptosis and signalling in acid sphingomyelinase deficient cells

BMC Cell Biology, 2001
Background Recent evidence suggests that the activation of a non-specific lipid scramblase during apoptosis induces the flipping of sphingomyelin from the cell surface to the cytoplasmic leaftet of the plasma membrane. Inner leaflet sphingomyelin is then
Sillence Dan J
doaj   +1 more source

Renal involvement in a patient with the chronic visceral subtype of acid sphingomyelinase deficiency resembles Fabry disease

JIMD Reports, 2021
Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disease (LSD) in which sphingomyelin accumulates due to deficient acid sphingomyelinase. In the chronic visceral subtype, organ manifestations are generally limited to the spleen, liver, and ...
Eline C. B. Eskes, Martijn J. C. van derLienden, Joris J. T. H. Roelofs, Liffert Vogt, Johannes M. F. G. Aerts, Jan Aten, Carla E. M. Hollak   +6 more
doaj   +1 more source

Staphylococcus aureus α-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides

Cellular Physiology and Biochemistry, 2017
Background/Aims: Staphylococcus aureus (S. aureus) infections are a major clinical problem and range from mild skin and soft-tissue infections to severe and even lethal infections such as pneumonia, endocarditis, sepsis, osteomyelitis, and toxic shock ...
Jie Ma, Erich Gulbins, Michael J. Edwards, Charles C. Caldwell, Martin Fraunholz, Katrin Anne Becker   +5 more
doaj   +1 more source

Src Mediates Epigallocatechin-3-O-Gallate-Elicited Acid Sphingomyelinase Activation

Molecules, 2020
Epigallocatechin-3-O-gallate (EGCG) is one of the major bioactive compounds known to be present in green tea. We previously reported that EGCG shows selective toxicity through activation of the protein kinase B (Akt)/cyclic guanosine monophosphate (cGMP)/
Motofumi Kumazoe, Mai Kadomatsu, Jaehoon Bae, Yushi Otsuka, Yoshinori Fujimura, Hirofumi Tachibana   +5 more
doaj   +1 more source

TAVI in Patient Suffering from Niemann–Pick Disease (Acid Sphingomyelinase Deficiency) with Concomitant Situs Inversus and Dextrocardia

Cardiology and Therapy, 2023
Acid sphingomyelinase deficiency (ASMD)—also known as Niemann–Pick (NP) disease—is a rare, autosomal recessive disorder which is characterized by deficiency of the lysosomal enzyme acid sphingomyelinase (ASM), resulting in excessive storage of lipids in ...
Daniele De Feo, Anna D’Anzi, Vincenzo Pestrichella, Pietro Scicchitano, Carlo Lafranceschina, Vito Caragnano, Fabio Tiecco, Antonella Scialpi, Giuliana Laronga, Marco Matteo Ciccone, Sabino Iliceto   +10 more
doaj   +1 more source

Role of Janus-Kinases in Major Depressive Disorder

Neurosignals, 2016
Background/Aims: Major depressive disorder is a severe, common and often chronic disease with a significant mortality due to suicide. The pathogenesis of major depression is still unknown. It is assumed that a reduction of neurogenesis in the hippocampus
Anne Gulbins, Heike Grassmé, Richard Hoehn, Marcus Kohnen, Michael J. Edwards, Johannes Kornhuber, Erich Gulbins   +6 more
doaj   +1 more source