Results 41 to 50 of about 2,680,532 (210)

Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells

Mediators of Inflammation, 2017
Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the ...
Samuela Cataldi, Cataldo Arcuri, Stéphane Hunot, François-Pierre Légeron, Carmen Mecca, Mercedes Garcia-Gil, Andrea Lazzarini, Michela Codini, Tommaso Beccari, Anna Tasegian, Bernard Fioretti, Giovanna Traina, Francesco Saverio Ambesi-Impiombato, Francesco Curcio, Elisabetta Albi   +14 more
doaj   +1 more source

Blockade of Experimental Multiple Sclerosis by Inhibition of the Acid Sphingomyelinase/Ceramide System

Neurosignals, 2017
Background: Multiple sclerosis (MS) is a severe and common autoimmune disorder of the central nervous system. Despite the availability of several novel treatment options, the disease is still poorly controlled, since the pathophysiological mechanisms are
Katrin Anne Becker, Ramona Halmer, Laura Davies, Brian D. Henry, Regan Ziobro-Henry, Yann Decker, Yang Liu, Erich Gulbins, Klaus Fassbender, Silke Walter   +9 more
doaj   +1 more source

Plasma membrane sphingomyelin and the regulation of HMG-CoA reductase activity and cholesterol biosynthesis in cell cultures.

Journal of Lipid Research, 1991
We have examined the mechanism of the inhibition of cholesterol synthesis in cells treated with exogenous sphingomyelinase. Treatment of rat intestinal epithelial cells (IEC-6), human skin fibroblasts (GM-43), and human hepatoma (HepG2) cells in culture ...
AK Gupta, H Rudney
doaj   +1 more source

Acid sphingomyelinase serum activity in control and ICU patients.

, 2014
This figure indicates median pre- and post-operative acid sphingomyelinase serum activity of the control group and median acid sphingomyelinase serum activity of the ICU group on admission.
Supandi Winoto-Morbach (501243), Matthias Kott (657467), Gunnar Elke (449417), Inéz Frerichs (20627), Norbert Weiler (20632), Stefan Schütze (320441), Günther Zick (20626), Maike Reinicke (657468), Dirk Schädler (20628)   +8 more
core   +1 more source

Acid Sphingomyelinase Activation and ROS Generation Potentiate Antiproliferative Effects of Mitomycin in HCC. [PDF]

Int J Mol Sci
Sphingolipids play a major role in the regulation of hepatocellular apoptosis and proliferation. We have previously identified sphingolipid metabolites as biomarkers of chronic liver disease and hepatocellular carcinoma.
Buitkamp S, Schwalm S, Jakobi K, Ferreiros N, Wünsche C, Zeuzem S, Gulbins E, Sarrazin C, Pfeilschifter J, Grammatikos G.   +9 more
europepmc   +2 more sources

Acid sphingomyelinase inhibition in stored erythrocytes reduces transfusion-associated lung inflammation

, 2017
Objective: We aimed to identify the role of the enzyme acid sphingomyelinase in the aging of stored units of packed red blood cells (pRBCs) and subsequent lung inflammation after transfusion.
Kleuser, Burkhard (Prof. Dr. rer. nat.), Hoehn, Richard S., Gulbins, Erich (Prof. Dr. med.), Midura, Emily F., Pritts, Timothy A., Jernigan, Peter L., Japtok, Lukasz, Edwards, Michael J., Caldwell, Charles C., Chang, Alex L., Lentsch, Alex B.   +10 more
core   +1 more source

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

Neurobiology of Disease
Loss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. Progranulin mutations cause abnormalities in lysosomal lipid processing, particularly of sphingolipids, major components of neural cell
Nicholas R. Boyle, Stephanie N. Fox, Aniketh S. Tadepalli, Nicholas T. Seyfried, Thomas Kukar, Eliana M. Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant, Erik D. Roberson   +12 more
doaj   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Down-regulation of acid sphingomyelinase and neutral sphingomyelinase-2 inversely determines the cellular resistance to plasmalemmal injury by pore-forming toxins. [PDF]

, 2018
Bacterial pore-forming toxins compromise plasmalemmal integrity, leading to Ca2+ influx, leakage of the cytoplasm, and cell death. Such lesions can be repaired by microvesicular shedding or by the endocytic uptake of the injured membrane sites.
Roman Schoenauer, Patrick Drücker, Draeger, Annette, Yu Larpin, Eduard B. Babiychuk, Viktoriia S. Babiychuk, Schönauer, Roman, Elita Avota, Fabian Schumacher, Annette Draeger, Schneider-Schaulies, S, Schumacher, F, Avota, E, Drücker, Patrick, Burkhard Kleuser, Babiychuk, Eduard, Babiychuk, Victoria, Larpin, Yu-Noël, Sibylle Schneider-Schaulies, René Köffel, Köffel, René, Kleusner, B, Kleuser, Burkhard (Prof. Dr. rer. nat.), Babiychuk, Eduard B., Schoenauer R, Draeger A, Larpin Y, Drücker P, Schneider-Schaulies, Sibylle, Schumacher F, Babiychuk EB, Larpin, Yu, Schneider-Schaulies S, Babiychuk, Viktoriia S., Avota, Elita, Avota E, Köffel R, Kleuser B, Schoenauer, Roman, Babiychuk VS, Schumacher, Fabian (Dr.)   +40 more
core   +1 more source

Immunoregulatory role of acid sphingomyelinase in allergic asthma [PDF]

Immunology, 2019
SummaryAcid sphingomyelinase (ASM) is one of the enzymes that catalyzes the breakdown of sphingomyelin to ceramide and phosphorylcholine. In this study, we aimed at elucidating the role of ASM in allergic asthma. We used an ovalbumin‐induced murine model of asthma where we compared wild‐type and ASM‐deficient mice.
Nina Sopel, Julia Kölle, Sonja Dumendiak, Sonja Koch, Martin Reichel, Cosima Rhein, Johannes Kornhuber, Susetta Finotto   +7 more
openaire   +2 more sources