Results 41 to 50 of about 25,568 (180)

Repurposing FIASMAs against Acid Sphingomyelinase for COVID-19: A Computational Molecular Docking and Dynamic Simulation Approach

Molecules, 2023
Over the past few years, COVID-19 has caused widespread suffering worldwide. There is great research potential in this domain and it is also necessary.
Aliza Naz, Sumbul Asif, Khairiah Mubarak Alwutayd, Sara Sarfaraz, Sumra Wajid Abbasi, Asim Abbasi, Abdulkareem M. Alenazi, Mohamed E. Hasan   +7 more
doaj   +1 more source

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

Neurobiology of Disease
Loss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. Progranulin mutations cause abnormalities in lysosomal lipid processing, particularly of sphingolipids, major components of neural cell
Nicholas R. Boyle, Stephanie N. Fox, Aniketh S. Tadepalli, Nicholas T. Seyfried, Thomas Kukar, Eliana M. Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant, Erik D. Roberson   +12 more
doaj   +1 more source

Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells [PDF]

, 2008
Background The ceramide generation is an early event in the apoptotic response to numerous stimuli including the oxidative stress and ceramide analogs mimic the stress effect and induce apoptosis.
Nataliya A Babenko, Elena G Shakhova
core   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Computational identification and experimental characterization of substrate binding determinants of nucleotide pyrophosphatase/phosphodiesterase 7 [PDF]

, 2011
Background: Nucleotide pyrophosphatase/phosphodiesterase 7 (NPP7) is the only member of the mammalian NPP enzyme family that has been confirmed to act as a sphingomyelinase, hydrolyzing sphingomyelin (SM) to form phosphocholine and ceramide.
Abby L Parrill, Daniel L Baker, Irene W Wanjala, Truc Pham   +3 more
core   +2 more sources

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia

Journal of Translational Medicine, 2019
Background There continues to be a great need for better biomarkers and host-directed treatment targets for community-acquired pneumonia (CAP). Alterations in phospholipid metabolism may constitute a source of small molecule biomarkers for acute ...
Haroon Arshad, Juan Carlos López Alfonso, Raimo Franke, Katina Michaelis, Leonardo Araujo, Aamna Habib, Yuliya Zboromyrska, Eva Lücke, Emilia Strungaru, Manas K. Akmatov, Haralampos Hatzikirou, Michael Meyer-Hermann, Astrid Petersmann, Matthias Nauck, Mark Brönstrup, Ursula Bilitewski, Laurent Abel, Jorg Sievers, Jordi Vila, Thomas Illig, Jens Schreiber, Frank Pessler   +21 more
doaj   +1 more source

Toxicity of oxidized phospholipids in cultured macrophages [PDF]

, 2012
Background: The interactions of oxidized low-density lipoprotein (LDL) and macrophages are hallmarks in the development of atherosclerosis. The biological activities of the modified particle in these cells are due to the content of lipid oxidation ...
Aflaki, Elma, Deigner, Hans, Dunai, Zsuzsanna, Hermetter, Albin, Koller, Daniel, Kratky, Dagmar, Purstinger, Gabriel, Stemmer, Ute, Zenzmaier, Elfriede   +8 more
core   +2 more sources

Early Radiation Therapy Response Assessment Using Multi‐Scale Photoacoustic Imaging

Advanced Science, EarlyView.
Tomographic and mesoscopic photoacoustics capture intratumoural features of radioresistance and response. ABSTRACT There is a critical unmet clinical need to identify biomarkers that predict and detect radiation therapy (RT) response in cancer. Using the unique capabilities of multi‐scale photoacoustic imaging (PAI) to depict tumor oxygenation and ...
Thierry L. Lefebvre, Mariam‐Eleni Oraiopoulou, Ellie V. Bunce, Thomas R. Else, Lorna C. Wright, Monika A. Golinska, Lina Hacker, Cara Brodie, Steven Kupczak, Yi Cheng, Lisa Young, Paul W. Sweeney, Sarah E. Bohndiek   +12 more
wiley   +1 more source

Sphingolipids in thyroid eye disease

Frontiers in Endocrinology, 2023
Graves’ disease (GD) is caused by an autoimmune formation of autoantibodies and autoreactive T-cells against the thyroid stimulating hormone receptor (TSHR).
Anne Gulbins, Gina-Eva Görtz, Erich Gulbins, Anja Eckstein   +3 more
doaj   +1 more source