Results 111 to 120 of about 2,680,532 (210)

Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1

, 2004
This paper reports that cocaine may induce a lysosomal storage disorder. Indeed, culture of Rat-1 fibroblasts with 250-500 microM cocaine induced after 2-3 days a major accumulation in lysosomes of electron-dense lamellar structures.
Lizarraga, Chantal, Nassogne, Marie-Cécile, Van Bambeke, Françoise, Wallemacq, Pierre, Levade, Thierry, Courtoy, Pierre J., N'Kuli, Francisca, Van Binst, Roger, Mingeot-Leclercq, Marie-Paule, Tulkens, Paul M.   +9 more
core   +1 more source

Lysosomal sphingomyelinase is not solicited for apoptosis signaling

, 2000
International audienceABSTRACT Stress‐induced activation of an acidic sphingomyelinase leading to generation of ceramide, an important lipid mediator, has been associated with apoptosis; however, the implication of this hydrolase has been questioned. The
Gouazé, Valérie, Uro-Coste, Emmanuelle, Cuvillier, Olivier, Bezombes, Christine, Salvayre, Robert, Jaffrézou, Jean‐pierre, Bruno, Alain, Carpentier, Stéphane, Andrieu-Abadie, Nathalie, Levade, Thierry, Laurent, Guy, Ségui, Bruno   +11 more
core   +1 more source

Features of liver damage in Niemann — Pick disease type A, A/B and B (deficiency of acidic sphingomyelinase)

Лечащий Врач
Background. Acid sphingomyelinase deficiency (Niemann – Pick disease) leads to the intracellular accumulation of sphingomyelin within the mononuclear phagocyte system, including liver, spleen, lungs and bone marrow.
Goar B. Movsisyan, Tatyana A. Bokova
doaj   +1 more source

Gentamicin Targets Acid Sphingomyelinase in Cancer: The Case of the Human Gastric Cancer NCI-N87 Cells

, 2019
Emerging literature implicates acid sphingomyelinase in tumor sensitivity/resistance to anticancer treatments. Gentamicin is a drug commonly used as an antimicrobial but its serendipity effects have been shown.
Federica Filomena Patria, Maria Rachele Ceccarini, Elisabetta Albi, Samuela Cataldi, Ivana Ferri, Tommaso Beccari, Michela Codini, Carmela Conte, Katia Fettucciari   +8 more
core   +1 more source

Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae

, 2000
The interaction with human phagocytes is a hallmark of symptomatic Neisseria gonorrhoeae infections. Gonococcal outer membrane proteins of the Opa family induce the opsoninindependent uptake of the bacteria that relies on CEACAM receptors and an active ...
Gulbins, Erich, Hauck, Christof R., Jendrossek, Verena, Ferlinz, Klaus, Bock, Jörg, Grassmé, Heike, Meyer, Thomas F.   +6 more
core  

Receiver operating characteristics curve (ROC) analysis of acid sphingomyelinase serum activity.

, 2014
ROC analyses were performed at all three time points: PCTbefore (fine dashed line), PCTpeak (dashed line), and PCTlow (solid line). ROC curves statistically significant different from 0.5 are marked with an asterisk (*).
Supandi Winoto-Morbach (501243), Matthias Kott (657467), Gunnar Elke (449417), Inéz Frerichs (20627), Norbert Weiler (20632), Stefan Schütze (320441), Günther Zick (20626), Maike Reinicke (657468), Dirk Schädler (20628)   +8 more
core   +1 more source

Acid sphingomyelinase, autophagy, and atherosclerosis [PDF]

Journal of Molecular Medicine, 2014
openaire   +2 more sources

Regulated Secretion of Acid Sphingomyelinase [PDF]

Journal of Biological Chemistry, 2010
Russell W. Jenkins, Daniel Canals, Jolanta Idkowiak-Baldys, Fabio Simbari, Patrick Roddy, David M. Perry, Kazuyuki Kitatani, Chiara Luberto, Yusuf A. Hannun   +8 more
openaire   +1 more source

Olipudase alfa enzyme replacement therapy. One-year outcomes in an adult patient with acid sphingomyelinase deficiency type B [PDF]

Introduction: Acid Sphingomyelinase Deficiency (ASMD) is a rare autosomal recessive lysosomal storage disorder caused by variants in the SMPD1 gene, leading to a deficiency in the activity of sphingomyelinase (ASM) that catabolizes sphingomyelin (SPM ...
Campos, T., Silva, A., Chaves, P.C., Pintalhão, M., Castro, R., Bastos, J., Leão Teles, Elisa, Rodrigues, E., Macedo, Fatima, da Silva Gaspar, Paulo Jorge Miranda, Cardoso, M.   +10 more
core   +1 more source

Targeting of Acid Sphingomyelinase, a Lysosomal Membrane Protein, Using Apolipoprotein E3-containing Nanodiscs. [PDF]

J Membr Biol
Metkar V, Benedicto VG, Zheng J, Zivkovic AM, Plascencia ND, Gredig T, Narayanaswami V.   +6 more
europepmc   +1 more source