Results 131 to 140 of about 15,882 (175)
Acid sphingomyelinase modulates anxiety-like behavior likely through toll-like receptor signaling pathway. [PDF]
Mol BrainYuan H +7 more
europepmc +1 more source
Prevalence of Cancer in Acid Sphingomyelinase Deficiency [PDF]
Journal of Clinical Medicine, 2021 Acid sphingomyelinase deficiency (ASMD) is an inherited lysosomal disease characterised by a diffuse accumulation of sphingomyelin that cannot be catabolised into ceramide and phosphocholine. We studied the incidence of cancer in ASMD patients. We retrospectively reviewed the medical records of the adult chronic visceral ASMD patients in our cohort ...
Thierry Levade +2 more
exaly +4 more sources
Acid Sphingomyelinase Deficiency: A Clinical and Immunological Perspective [PDF]
International Journal of Molecular Sciences, 2021 Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disease caused by deficient activity of acid sphingomyelinase (ASM) enzyme, leading to the accumulation of varying degrees of sphingomyelin. Lipid storage leads to foam cell infiltration in tissues, and clinical features including hepatosplenomegaly, pulmonary insufficiency and in some ...
Andrea Elena Dardis +2 more
exaly +5 more sources
Acid Sphingomyelinase Deficiency Ameliorates Farber Disease [PDF]
International Journal of Molecular Sciences, 2019 Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan. We have recently reported a novel acid ceramidase deficiency model that mirrors the human disease closely.
Stephanie Kadow +2 more
exaly +5 more sources
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Acid sphingomyelinase in macrophage apoptosis
Current Opinion in Lipidology, 2004This article presents an overview of the recent progress in understanding metabolic and functional interrelationships of biologically active sphingolipids related to the sphingomyelin signal transduction pathway in relation to the regulation of apoptosis in macrophages.Ceramide generation is an essential, early step in apoptosis in numerous systems ...
Urs P, Steinbrecher +2 more
openaire +2 more sources
2013
The enzyme acid sphingomyelinase catalyzes the hydrolysis of sphingomyelin to ceramide. The importance of the enzyme for cell functions was first recognized in Niemann-Pick disease type A and B, the genetic disorders with a massive accumulation of sphingomyelin in many organs. Studies in the last years demonstrated that the enzyme also has an important
Henry, Brian +4 more
openaire +3 more sources
The enzyme acid sphingomyelinase catalyzes the hydrolysis of sphingomyelin to ceramide. The importance of the enzyme for cell functions was first recognized in Niemann-Pick disease type A and B, the genetic disorders with a massive accumulation of sphingomyelin in many organs. Studies in the last years demonstrated that the enzyme also has an important
Henry, Brian +4 more
openaire +3 more sources
The emerging role of Acid Sphingomyelinase in autophagy
Apoptosis, 2015Autophagy, the main intracellular process of cytoplasmic material degradation, is involved in cell survival and death. Autophagy is regulated at various levels and novel modulators of its function are being continuously identified. An intriguing recent observation is that among these modulators is the sphingolipid metabolising enzyme, Acid ...
C. Perrotta +6 more
openaire +3 more sources
Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons [PDF]
Frontiers in Physiology, 2014 Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of disorders, in particular major depression and neuropathic pain. In the 1970s the ability of tricyclic antidepressants to inhibit acid sphingomyelinase (ASM) was discovered. The enzyme ASM catalyzes the hydrolysis of sphingomyelin to ceramide.
Deepa Sharma +2 more
exaly +5 more sources
Functional Inhibitors of Acid Sphingomyelinase (FIASMAs)
2013Sphingolipids are not only structural components of biological membranes, but also play an important role in cellular signalling and, thus, are involved in cell proliferation and differentiation but also stress and cell death. It is therefore of great clinical relevance to define inhibitors of the enzymes involved in sphingolipid metabolism.
Kornhuber, Johannes +3 more
openaire +2 more sources