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Ursolic Acid Inhibits Acid Sphingomyelinase in Intestinal Cells
Phytotherapy Research, 2012Ursolic acid (UA) has antiinflammatory and anticancer effects on mammalian cells. Increase in acid sphingomyelinase (SMase) is associated with several inflammatory diseases including inflammatory bowel diseases. The enzyme has become a target for drug discovery. The present study examined the roles of UA on acid SMase in intestinal cells. We found that
Ping, Zhang +2 more
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Use of Acid Sphingomyelinase for Cancer Therapy
2013Acid sphingomyelinase (ASM) is a lipid hydrolase that cleaves the sphingolipid, sphingomyelin, into ceramide. Mutations in the ASM gene (SMPD1) result in the rare lysosomal storage disorder, Niemann-Pick disease (NPD). In addition to its role in NPD, over the past two decades, the importance of sphingolipids, and ASM in particular, in normal physiology
Radoslav, Savić, Edward H, Schuchman
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Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis
Multiple Sclerosis and Related Disorders, 2019Multiple sclerosis (MS) lacks reliable biomarkers that reflect disease activity. Recent evidence suggests that an altered sphingolipid metabolism is associated with MS pathogenesis.To explore acid sphingomyelinase (ASM) activity and altered sphingolipid metabolism as potential biomarkers in serum of MS patients, to predict active and progressive ...
C.E. Leurs +10 more
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Immunological Studies on Acidic Sphingomyelinase
1986Intrinsic properties of acidic sphingomyelinase cause major difficulties in attempts to produce a satisfactory antibody. The only two published papers do not carry conviction: the monoclonal antibody described by Freeman et al. (1983) was not demonstrated to precipitate sphingomyelinase activity while monospecificity of the polyclonal antibody prepared
Robert Rousson +2 more
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Purification to Homogeneity of Human Placental Acid Sphingomyelinase
Biotechnology and Applied Biochemistry, 1989Acid sphingomyelinase was purified to homogeneity from human placenta in the presence of a dialyzable detergent, n‐octyl‐beta‐D‐glucopyranoside. The major steps in the procedure included column chromatographies with Con A‐Sepharose, sphingosylphosphorylcholine‐Sepharose 4B, hexyl‐agarose, and Mono P.
L, Zou, N, Kojima, M, Kito, K, Yagi
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Acid Sphingomyelinase of Human Brain: Purification to Homogeneity
Journal of Neurochemistry, 1982Abstract: Acid sphingomyelinase (sphingomyelin phosphodiesterase, EC 3.1.4.12) was purified from human brain by extraction with 0.1% Triton X‐100, followed by sequential chromatography on Concanavalin A‐Sepharose, octyl‐Sepharose, hydroxylapatite, DEAE‐cellulose, red A‐agarose, Sephadex G‐200, and DEAE‐cellulose with ampholyte elution ...
T, Yamanaka, K, Suzuki
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Development of carbohydrate-derived inhibitors of acid sphingomyelinase
Bioorganic & Medicinal Chemistry, 2010The acid sphingomyelinase is an emerging drug target, especially for inflammatory lung diseases. Presently, there are no directly-acting potent inhibitors available for cell-based studies. The potent inhibitor phosphatidylinositol-3,5-bisphosphate (PtdIns3,5P2) is not only unsuited for cell culture studies, but also does not provide hints for further ...
Anke G, Roth +2 more
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Potent Inhibition of Acid Sphingomyelinase by Phosphoinositide Analogues
ChemBioChem, 2009AbstractThe different mammalian sphingomyelinases are involved in cell regulation, apoptosis and inflammatory events. Recent reports suggest pharmacological potential especially for inhibitors of the acid sphingomyelinase. Phosphatidyl inositol‐3,5bisphosphate (PtdIns3,5P2) is the most potent selective acid sphingomyelinase inhibitor known to date.
Anke Gundula, Roth +2 more
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Acid Sphingomyelinase-derived Ceramide Signaling in Apoptosis
2006A variety of studies demonstrate a central role for ASM and ceramide in several forms of apoptosis. Ceramide seems to regulate the activity of certain proteins and, thus, may function, in some circumstances, as a second messenger. In addition, the concept of raft modification by ceramide provides a comprehensive model for cellular effects of ceramide ...
Erich, Gulbins, Richard, Kolesnick
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Acid and neutral sphingomyelinases: roles and mechanisms of regulation
Biochemistry and Cell Biology, 2004Ceramide, an emerging bioactive lipid and second messenger, is mainly generated by hydrolysis of sphingomyelin through the action of sphingomyelinases. At least two sphingomyelinases, neutral and acid sphingo myelinases, are activated in response to many extracellular stimuli.
Norma, Marchesini, Yusuf A, Hannun
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