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The lysosomal targeting of acid sphingomyelinase /
2005Acid sphingomyelinase (ASM), a member of the saposin like protein (SAPLIP) family, is a lysosomal hydrolase that converts sphingomyelin to ceramide. The deficient activity of ASM causes a variant form (i.e., type A/B) of the inherited disorder Niemann-Pick disease. The lysosomal targeting mechanism of ASM has not been conclusively identified.
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Acid sphingomyelinase in steatohepatitis
2016Steatohepatitis (SH) is an intermediate stage of fatty liver disease and one of the most common causes of chronic liver disease worldwide that may progress to cirrhosis and liver cancer. SH encompasses alcoholic (ASH) and nonalcoholic steatohepatitis (NASH), the latter being of particular concern due to its association with obesity and insulin ...
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Inhibition of acid sphingomyelinase increases regulatory T cells in humans
Brain Communications, 2021Jürgen Schneider-Schaulies +2 more
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[Acid sphingomyelinase deficiency: A review].
La Revue de medecine interneAcid sphingomyelinase deficiency, formerly known as Niemann-Pick disease types B, A/B, and B, is a rare genetic disorder. It is an inherited autosomal recessive disease, linked to mutations in the SMPD1 gene. It is a lysosomal storage disease that leads to the accumulation of sphingomyelin mainly in macrophages, resulting in a multisystemic phenotype ...
Martin, Michaud +3 more
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mRNA Expression of SMPD1 Encoding Acid Sphingomyelinase Decreases upon Antidepressant Treatment
International Journal of Molecular Sciences, 2021Tanja Richter-Schmidinger +2 more
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Acid sphingomyelinase possesses a domain homologous to its activator proteins: Saposins B and D
Protein Science, 1994Chris Ponting
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