Results 31 to 40 of about 9,968 (290)

Genomic insights into citrus domestication and its important agronomic traits

open access: yesPlant Communications, 2021
Citrus originated in Southeast Asia, and it has become one of the most important fruit crops worldwide. Citrus has a long and obscure domestication history due to its clonal propagation, long life cycle, wide sexual compatibility, and complex genetic ...
Muhammad Junaid Rao, Hao Zuo, Qiang Xu
doaj   +1 more source

Bile acids: regulation of synthesis [PDF]

open access: yesJournal of Lipid Research, 2009
Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear receptors and cell signaling pathways that regulate lipid, glucose, and energy metabolism.
openaire   +3 more sources

Regulation of mTORC1 by amino acids [PDF]

open access: yesTrends in Cell Biology, 2014
The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which drive mTORC1 to the ...
Bar-Peled, Liron, Sabatini, David
openaire   +4 more sources

Amino Acids as Regulators of Proteolysis [PDF]

open access: yesThe Journal of Nutrition, 2003
Proteolysis, as well as protein synthesis, is a major process that contributes to the body protein turnover. Despite the huge variety of proteases in the body, there are very few proteolytic systems contributing to the complete hydrolysis of proteins to amino acids.
Motoni, Kadowaki, Takumi, Kanazawa
openaire   +2 more sources

Regulation of mTOR by Phosphatidic Acid? [PDF]

open access: yesCancer Research, 2007
Abstract Interest in the regulation of the mammalian target of rapamycin (mTOR) has increased substantially in recent years largely because of an apparent link between mTOR and survival signals in human cancer cells. Much has been learned about the regulation of mTOR in response to survival signals generated by phosphatidylinositol 3 ...
openaire   +2 more sources

Paclobutrazol in the flowering management affects the quality of Malpighia emarginata fruits

open access: yesPesquisa Agropecuária Tropical, 2020
Floral management using the growth regulator paclobutrazol may be an alternative for promoting the uniformity of flowering and fruiting in West Indian cherry (Malpighia emarginata D.C.) plants.
Erivan dos Santos Sousa   +5 more
doaj   +1 more source

ZLN005 improves the survival of polymicrobial sepsis by increasing the bacterial killing via inducing lysosomal acidification and biogenesis in phagocytes

open access: yesFrontiers in Immunology, 2023
Polymicrobial sepsis still has a high mortality rate despite the development of antimicrobial agents, elaborate strategies to protect major organs, and the investment of numerous medical resources.
Yosuke Suzuki   +7 more
doaj   +1 more source

A reciprocal feedback of miR-548ac/YB-1/Snail induces EndMT of HUVECs during acidity microenvironment

open access: yesCancer Cell International, 2021
Background Researches indicated the process of Endothelial-Mesenchymal-Transition (EndMT) of vascular endothelial cells (ECs) was critically involved in the progression of tumor. ECs demonstrated functional and phenotypic heterogeneity when located under
Jingyuan Chen   +10 more
doaj   +1 more source

Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2

open access: yesCell Reports, 2023
Summary: Acidic environments reduce the intracellular pH (pHi) of most cells to levels that are sub-optimal for growth and cellular functions. Yet, cancers maintain an alkaline cytoplasm despite low extracellular pH (pHe).
Johanna Michl   +9 more
doaj   +1 more source

Simultaneous quantification of ferrous gluconate and calcium gluconate in foods using liquid chromatography–tandem mass spectrometry (LC–MS/MS)

open access: yesApplied Biological Chemistry, 2023
Ferrous gluconate and calcium gluconate are used as food acidity regulators in South Korea, Japan, the European Union (EU), and other countries. A simultaneous analytical method was developed to quantify ferrous gluconate and calcium gluconate in food ...
Yeong-Ju Park   +7 more
doaj   +1 more source

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