Results 21 to 30 of about 143,662 (295)

High flow nasal cannula versus noninvasive ventilation in the treatment of acute hypercapnic respiratory failure: A systematic review and meta‐analysis

The Clinical Respiratory Journal, 2023
Chronic obstructive pulmonary disease can lead to acute hypercapnic respiratory failure (AHRF), often treated using noninvasive ventilation (NIV). Emerging research suggests the potential utility of high flow nasal cannula (HFNC) for AHRF.
Aisling C. Fahey, Martina O'Connell, Nicola Cornally, Mohamad M. Saab   +3 more
doaj   +1 more source

Intoxicación por cianuro, perspectiva desde urgencias: reporte de dos casos y revisión de la literatura

Medicina U.P.B., 2019
Aunque poco común, la intoxicación por cianuro acarrea una mortalidad alta, sobre todo, cuando no se administra el tratamiento oportuno. La exposición a este tóxico puede darse por inhalación o por ingestión oral.
Andrés Felipe Estrada Atehortúa, Mateo Zuluaga Gómez, Marie Claire Berrouet Mejía   +2 more
doaj   +1 more source

GPR68 Mediates Lung Endothelial Dysfunction Caused by Bacterial Inflammation and Tissue Acidification

Cells
Tissue acidification resulting from dysregulated cellular bioenergetics accompanies various inflammatory states. GPR68, along with other members of proton-sensing G protein-coupled receptors, responds to extracellular acidification and has been ...
Pratap Karki, Yunbo Ke, Chenou Zhang, Kamoltip Promnares, Yue Li, Charles H. Williams, Charles C. Hong, Konstantin G. Birukov, Anna A. Birukova   +8 more
doaj   +1 more source

Muscle fatigue, bioenergetic responses and metabolic economy during load‐ and velocity‐based maximal dynamic contractions in young and older adults

Physiological Reports, 2023
We evaluated whether task‐dependent, age‐related differences in muscle fatigue (contraction‐induced decline in normalized power) develop from differences in bioenergetics or metabolic economy (ME; mass‐normalized work/mM ATP).
Liam F. Fitzgerald, Miles F. Bartlett, Jane A. Kent   +2 more
doaj   +1 more source

The role of neutrophilia in hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality outcome in critically ill COVID-19 patients

Frontiers in Molecular Biosciences
IntroductionCOVID-19 severity and high in-hospital mortality are often associated with severe hypoxemia, hyperlactatemia, and acidosis, yet the key players driving this association remain unclear.
Basma A. Yasseen, Aya A. Elkhodiry, Hajar El-sayed, Mona Zidan, Azza G. Kamel, Mohamed A. Badawy, Marwa S. Hamza, Riem M. El-Messiery, Mohamed El Ansary, Engy A. Abdel-Rahman, Engy A. Abdel-Rahman, Sameh S. Ali   +11 more
doaj   +1 more source

The logistic organ dysfunction system score predicts the prognosis of patients with alcoholic ketoacidosis

Renal Failure, 2018
Alcoholic ketoacidosis (AKA) is occasionally associated with multiple complications leading to death. However, no study has yet evaluated prognostic factors in patients with AKA.
Ha Nee Jang, Hee Jung Park, Hyun Seop Cho, Eunjin Bae, Tae Won Lee, Se-Ho Chang, Dong Jun Park   +6 more
doaj   +1 more source

A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs

Biology, 2020
Extracellular vesicles (EVs), such as exosomes or oncosomes, often carry oncogenic molecules derived from tumor cells. In addition, accumulating evidence indicates that tumor cells can eject anti-cancer drugs such as chemotherapeutics and targeted drugs ...
Takanori Eguchi, Eman Ahmed Taha, Stuart K. Calderwood, Kisho Ono   +3 more
doaj   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

Carbonic Anhydrase II Deficiency: A Rare Case of Severe Obstructive Sleep Apnea

Frontiers in Pediatrics, 2018
The term osteopetrosis describes a group of rare hereditary diseases of the skeleton, characterized by an increase in bone density, caused by a defect in the development or function of osteoclasts.
Emanuela di Palmo, Marcella Gallucci, Elena Tronconi, Rosalba Bergamaschi, Salvatore Cazzato, Claudio La Scola, Giampaolo Ricci, Andrea Pession   +7 more
doaj   +1 more source