ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity [PDF]
Nature Communications, 2018 The atypical chemokine receptor ACKR2 regulates immune responses. Here the authors confirm that ACKR2 depletion promotes primary tumor growth but show it has an anti-metastatic effect in mouse models of breast cancer by affecting myeloid differentiation ...
Matteo Massara +12 more
doaj +9 more sources
The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]
Shock, 2018 Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos +15 more
core +5 more sources
Elevated ACKR2 expression is a common feature of inflammatory arthropathies [PDF]
Rheumatology, 2017 Objectives. Chemokines are essential contributors to leucocyte accumulation at sites of inflammatory pathology. Interfering with chemokine or chemokine receptor function therefore represents a plausible therapeutic option.
Baldwin, Helen M. +6 more
core +5 more sources
The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury. [PDF]
PLoS ONE, 2017 The atypical chemokine receptor ACKR2 promotes resolution of acute inflammation by operating as a scavenger receptor for inflammatory CC chemokines in several experimental models of inflammatory disorders, however its role in the brain remains unclear ...
Thomas M Woodcock +10 more
doaj +5 more sources
The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]
The Journal of Immunology, 2018 Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi +12 more
core +5 more sources
Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland [PDF]
Development, 2016 Macrophages are important regulators of branching morphogenesis during development and postnatally in the mammary gland. Regulation of macrophage dynamics during these processes can therefore have a profound impact on development.
Cairney, Claire J. +7 more
core +5 more sources
Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia [PDF]
Cells, 2023 Resveratrol is a polyphenol that acts as antioxidants do, protecting the body against diseases, such as diabetes, cancer, heart disease, and neurodegenerative disorders, such as Alzheimer’s (AD) and Parkinson’s diseases (PD).
Rosa Calvello +5 more
doaj +2 more sources
Role of Atypical Chemokine Receptors in Microglial Activation and Polarization [PDF]
Frontiers in Aging Neuroscience, 2017 Inflammatory reactions occurring in the central nervous system (CNS), known as neuroinflammation, are key components of the pathogenic mechanisms underlying several neurological diseases.
Valentina Salvi +6 more
doaj +3 more sources
Atypical chemokine receptor 2 expression is directly regulated by hypoxia inducible factor-1 alpha in cancer cells under hypoxia [PDF]
Scientific ReportsLack of significant and durable clinical benefit from anti-cancer immunotherapies is partly due to the failure of cytotoxic immune cells to infiltrate the tumor microenvironment.
Alice Benoit +4 more
doaj +2 more sources
CCL14, identified by multi-omics approach, serves as a novel indicator of disease severity and progression in lymphangioleiomyomatosis [PDF]
Orphanet Journal of Rare DiseasesBackground Lymphangioleiomyomatosis (LAM) is a rare, multisystemic metastatic disease. Chemokines are implicated in promoting LAM cell migration and tumor progression.
Wenxue Bai +10 more
doaj +2 more sources