Results 11 to 20 of about 1,254 (143)

Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland [PDF]

Development, 2016
Macrophages are important regulators of branching morphogenesis during development and postnatally in the mammary gland. Regulation of macrophage dynamics during these processes can therefore have a profound impact on development.
Cairney, Claire J., Graham, Gerard J., Hansell, Christopher A., Hewit, Kay D., Lee, Kit M., Pallas, Kenneth J., Stein, Torsten, Wilson, Gillian J.   +7 more
core   +5 more sources

MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2 [PDF]

Journal of Biological Chemistry, 2018
Chemokines are the principal regulators of leukocyte migration and are essential for initiation and maintenance of inflammation. Atypical chemokine receptor 2 (ACKR2) binds and scavenges proinflammatory CC-chemokines, regulates cutaneous T-cell ...
Burden, AD, Graham, GJ, Kurowska-Stolarska, M, McKimmie, CS, Schütte, F, Shams, K   +5 more
core   +6 more sources

ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity [PDF]

Nature Communications, 2018
Italian Association for Cancer Research (AIRC—IG 15438) to R.B. and in part by a grant from the Italian Ministry of Health (GR-2010-2307975) to F.F. and by a grant HEALTH-F4-2011-281608 (TIMER) to A.M.. L.C.
A Levoye, A Mantovani, A Mantovani, A Mantovani, A Mantovani, A Müller, A Rot, AJ Casbon, B Savino, B Savino, BN Bidwell, BZ Qian, C Melani, CA Hansell, D Hartl, D Zhang, DG DeNardo, EB Eruslanov, EM Borroni, F Balkwill, F Ficara, FO Souto, FY Wu, G Bottai, G Lazennec, J Jablonska, JM Adrover, JW Griffith, K Ottersbach, K Pande, M Massara, M Shen, MG Borrello, ML Allende, MT Chow, O Bonavita, O Bonavita, R Bonecchi, R Bonecchi, R Bonecchi, R Bonecchi, R Bonecchi, RJ Nibbs, RJ Nibbs, S Rovero, S Vetrano, SB Coffelt, SB Coffelt, T Baba, T Schioppa, Y Si, Y Zhu, Z Granot, ZG Fridlender   +53 more
core   +9 more sources

Enhanced CCR2 expression by ACKR2-deficient NK cells enhances increases tumoricidal cell therapy efficacy [PDF]

Journal of Leukocyte Biology
Chemokines regulate leukocyte navigation to inflamed sites and specific tissue locales and may therefore be useful for ensuring accurate homing of cell therapeutic products.
Bartolini, Robin, Burgoyne, Paul, Campbell, John D.M., Campbell, Jordan, Galatis, Dimitrios, Gamble, Alistair, Graham, Gerard J., Hansell, Chris, Hayes, Alan J., Love, Samantha, McElroy, Daniel, Pingen, Marieke, Schuette, Fabian, Vidler, Francesca, Wilson, Gillian   +14 more
core   +3 more sources

Selective expression and significance of ACKR2 in lung aerocytes. [PDF]

J Immunother Cancer
Background ACKR2 is an atypical chemokine receptor that plays a significant role in regulating inflammation by binding to inflammatory CC chemokines and facilitating their degradation. Previous findings suggest that the genetic absence of ACKR2 leads to heightened tumor growth in inflammation-driven models ...
Albano F, Mollica Poeta V, Zotti L, Castagna A, Felicetta A, Mesaglio A, Zaghen E, Sironi M, Capucetti A, Di Donato R, Laffranchi M, Massara M, Carriero R, Condorelli G, Sozzani S, Mantovani A, Locati M, Bonecchi R.   +17 more
europepmc   +4 more sources

CXCL14 promotes metastasis of non-small cell lung cancer through ACKR2-depended signaling pathway. [PDF]

Int J Biol Sci, 2023
Background: Lung cancer is a malignant tumor with metastatic potential. Chemokine ligand 14 (CXCL14) has been reported to be associated with different cancer cell migration and invasion. However, few studies have explored the function of CXCL14 and its specific receptor in lung cancer metastasis.
Chang TM, Chiang YC, Lee CW, Lin CM, Fang ML, Chi MC, Liu JF, Kou YR.   +7 more
europepmc   +3 more sources

CXCL10 Is an Agonist of the CC Family Chemokine Scavenger Receptor ACKR2/D6 [PDF]

Cancers, 2021
Atypical chemokine receptors (ACKRs) are important regulators of chemokine functions. Among them, the atypical chemokine receptor ACKR2 (also known as D6) has long been considered as a scavenger of inflammatory chemokines exclusively from the CC family. In this study, by using highly sensitive β-arrestin recruitment assays based on NanoBiT and NanoBRET
Andy Chevigné, Bassam Janji, Max Meyrath, Nathan Reynders, Giulia D’Uonnolo, Tomasz Uchański, Malina Xiao, Guy Berchem, Markus Ollert, Yong-Jun Kwon, Muhammad Zaeem Noman, Martyna Szpakowska   +11 more
openaire   +3 more sources

ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology [PDF]

Frontiers in Immunology, 2017
The lymphatic system plays an important role in the induction of the immune response by transporting antigens, inflammatory mediators, and leukocytes from peripheral tissues to draining lymph nodes. It is emerging that lymphatic endothelial cells (LECs) are playing an active role in this context via the expression of chemokines, inflammatory mediators ...
O. Bonavita, V. Mollica Poeta, E. Setten, M. Massara, R. Bonecchi   +4 more
openaire   +2 more sources

Chemoradiotherapy-induced ACKR2⁺ tumor cells drive CD8⁺ T cell senescence and cervical cancer recurrence. [PDF]

Cell Rep Med
Tumor recurrence after chemoradiotherapy is challenging to overcome, and approaches to predict the recurrence remain elusive. Here, human cervical cancer tissues before and after concurrent chemoradiotherapy (CCRT) analyzed by single-cell RNA sequencing reveal that CCRT specifically promotes CD8+ T cell senescence, driven by atypical chemokine receptor
Dai D, Pei Y, Zhu B, Wang D, Pei S, Huang H, Zhu Q, Deng X, Ye J, Xu J, Chen X, Huang M, Xiao Y.   +12 more
europepmc   +3 more sources

ACKR2: Nature’s Decoy Receptor Lures Unsuspecting Chemokines in Psoriasis [PDF]

Journal of Investigative Dermatology, 2017
While we know much about the processes mediated by the Th17 inflammatory pathway that is crucial in psoriasis, we actually know little about the processes by which most psoriatic patients maintain what grossly looks like non-inflamed, normal skin in the face of massive inflammatory changes in nearby affected skin. Other molecular regulators that defend
Tomotaka, Mabuchi, Samuel T, Hwang
openaire   +2 more sources