Results 181 to 190 of about 5,616 (261)

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen   +6 more
wiley   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte   +3 more
wiley   +1 more source

The Epistemic Generativity of Using a Model of a Big Idea

open access: yesScience Education, EarlyView.
ABSTRACT Science instruction should involve learners in generating and warranting ideas, what we call epistemic generation. In modeling instruction, epistemic generation should be achieved by coordinating a model structure with the experienced world in reciprocal directions denoted as developing models and using models. In the former, a model structure
Jonathan T. Shemwell, Daniel K. Capps
wiley   +1 more source

Assessment of nurses' workplace silence behaviour motives: A cross-sectional study. [PDF]

open access: yesInt J Nurs Sci
Alhojairi HM   +4 more
europepmc   +1 more source

Identity Play: Middle School Youths' Provisional Self‐Making in Horizon‐Expanding STEM Spaces

open access: yesScience Education, EarlyView.
ABSTRACT This study introduces identity play as an analytic construct for science education to explore improvisational dimensions of middle school students' STEM identity development in multiple out‐of‐school learning experiences focused on environmental problem‐solving.
Heidi B. Carlone, Alison K. Mercier
wiley   +1 more source

Sliding Doors: Frame Uptake and Rejection by Learners in a Museum‐Based Climate Learning Experience

open access: yesScience Education, EarlyView.
ABSTRACT Science education efforts that support public understanding of modern climate change are critically needed. However, implementing climate‐related learning experiences can be challenging, as public audiences tend to experience a wide range of understandings of and emotions around the issue. In light of these challenges, many scholars have posed
Lynne Zummo   +7 more
wiley   +1 more source

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